SOLICITATION NOTICE
A -- Development and Maintenance of a Multigenotypic Aged Mouse Colony
- Notice Date
- 8/10/2009
- Notice Type
- Presolicitation
- NAICS
- 541712
— Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Mental Health, Contracts Management Branch, 6001 Executive Blvd, Rm 8154, MSC 9661, Bethesda, Maryland, 20892-9661
- ZIP Code
- 20892-9661
- Solicitation Number
- HHS-NIH-NIDA(AG)-RFP-09-086
- Point of Contact
- Teresa A. Baughman, Phone: (301) 443-1193
- E-Mail Address
-
baughmat@nida.nih.gov
(baughmat@nida.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- PRESOLICITATION NOTICE The National Institute on Aging (NIA), National Institutes of Health (NIH), Department of Health and Human Services (DHHS) intends to recompete a requirement currently being performed by Charles River Laboratories under NIA Contract HHSN260200400007C (N01-AG-40007). This procurement is being competed under full and open competitive procedures under NAICS 541712. It is anticipated that a single cost reimbursement, completion type contract will be awarded for a 9-year period of performance beginning on or about May 1, 2010, with an anticipated level of effort of approximately 5 FTEs in year 1, 10 FTEs in year 2, 16 FTEs in each of years 3-7, 11 FTEs in year 8 and 8 FTEs in year 9., to develop, maintain and distribute a standing colony of aged, genetically defined laboratory mice for use by investigators in studies of aging. This colony is to be developed and maintained within controlled and defined barrier environments where animals are monitored and characterized for disease status and markers of genetic purity. Current and projected experiments using rodents to model the aging processes and age-related diseases in humans require animals of defined genotype and controlled environmental and health status. Only with the meticulous, long-term control of genetic and environmental variables is it possible to maintain relevant animal models that may be used to study many of the biological and behavioral processes in aging. Therefore, a continuous supply of genetically defined, well characterized inbred and hybrid laboratory animals is essential for a program of research on aging Specifically, the Contractor shall develop, maintain and distribute a standing colony of aged mice of NIA-specified genotypes for use by investigators in studies of aging. The expected duration of this colony, and therefore of this contract, is nine years. During years 1 through 2, animals shall be entered into the colony, but few animals shall be removed from the colony except for the purposes of monitoring health and genetic purity. However, if the need should arise, animals may be distributed from the colony at anytime at the direction of the Contracting Officer's Technical Representative (COTR). During years 3 through 7, animals shall continue to be entered into the colony and animals shall be distributed to investigators. This should be a period of stable operation with young animals entering the colony at approximately the same rate as older animals leave the colony due to distribution and normal attrition. The final two year period, years 8 and 9, will serve as the colony close-out period. Animals shall be maintained and disbursed, but entry of animals shall cease at the beginning of year 8 or when entries begin in a renewal contract colony. Thus the population in this contract colony will decline over the last two year period to a point of near zero or very few animals at the end of year nine. The colony population at the end of each year of the nine year period should be approximately as follows: YEAR 1 10,000 YEAR 4 72,000 YEAR 7 72,000 YEAR 2 48,000 YEAR 5 72,000 YEAR 8 40,000 YEAR 3 72,000 YEAR 6 72,000 YEAR 9 NEAR 0 The Contractor shall acquire foundation stock for four inbred strains of mice and shall re-derive the stock by caesarian section or embryo transfer under barrier conditions. After re-derivation, testing to confirm genetic purity and SPF health status shall be performed on the foundation colony, and breeding colonies will be established for the four inbred strains and two derivative hybrid strains. Mice will be entered into the aging colony at levels defined in the contract Statement of Work (SOW), currently a total of 4,150 mice per month (the hybrid strains account for approximately 5% of the total entry levels). The Contractor shall provide all production space needed for the colony, including at least two independent barriers to house the colony, with independent back-up and alarm systems. Since this is an aging colony, the Contractor must be prepared to house the animals for up to 2-3 years. Mice shall be provided with sterilized food (formulation consistent with NIH31 open formula) and bedding, and environmental conditions (temperature, humidity range, light cycle, water treatment, etc.) as defined in the SOW. Semi-annual genetic monitoring of the breeding colonies and quarterly health monitoring of the aging colonies shall be performed and reported to the Project Officer as well as be included in the semi-annual progress reports. Genetic monitoring shall be accomplished by a panel of microsatellite markers that distinguish the inbred strains. Health monitoring shall include external exams for parasites, microbiology, serology, and histology. The Contractor shall ship the mice to investigators, providing secure shipping crates, food and water sources, and climate-controlled transport. The Contractor shall invoice customers for the cost of the animals and all shipping costs, and apply the remittance to the cost of the contract. The Contractor shall weekly provide an inventory of the aging colony in a format approved by the COTR. All responsible sources may submit a proposal which will be considered by the agency. This notice does not commit the Government to award a contract. No collect calls will be accepted. No facsimile transmissions will be accepted. Contracting Office Address: NIMH/NIA Contracts Management Branch NIDA Neuroscience COAC 6001 Executive Blvd, Rm 8154, MSC 9661 Bethesda, Maryland 20892-9661 Primary Point of Contact.: Teresa A. Baughman, Contracting Officer baughmat@nida.nih.gov Phone: (301) 443-1193 Fax: (301) 443-0501
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIMH/HHS-NIH-NIDA(AG)-RFP-09-086/listing.html)
- Record
- SN01906013-W 20090812/090811001640-ab18731a5f8edf3ddf828d1969c71bdc (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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