SOLICITATION NOTICE
B -- RECOVERY - Sequencing for The Cancer Genome Atlas (TCGA) Program
- Notice Date
- 12/17/2009
- Notice Type
- Presolicitation
- NAICS
- 541380
— Testing Laboratories
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions-Treatment and Support Branch, Bldg 244, Room 112, Frederick, Maryland, 21702
- ZIP Code
- 21702
- Solicitation Number
- N02-CO-07005-65
- Point of Contact
- Timothy Crilley, Phone: 301/228-4224, Robin M. Irving, Phone: (301) 228-4220
- E-Mail Address
-
tcrilley@mail.nih.gov, irvingr@mail.nih.gov
(tcrilley@mail.nih.gov, irvingr@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITATION AND AMENDMENTS THAT MAYBE ISSUED. THIS ACQUISITION IS BEING ADVERTISED UNDER FULL AND OPEN COMPETITION. The National Cancer Institute (NCI), National Institutes of Health (NIH), is seeking qualified contractor(s) to provide sequencing services in support of The Cancer Genome Atlas (TCGA). TCGA is a comprehensive, collaborative effort led by the National Institutes of Health (NIH) to map the genomic changes that occur in major types and subtypes of cancer. The purpose of this project is to perform genomic DNA sequencing and initial analysis for the comprehensive characterization of sequence from the genomes of cancer specimens and associated normal tissues. This project will catalog comprehensively somatic DNA changes that are associated with cancer. The contractor shall utilize the most advanced DNA sequencing technologies and genomic analysis computational methods to investigate at least 400 and as many as 1000 cancer cases (specific types to be identified by the NCI) over the first eighteen (18) months of the contract. A case includes DNA from tumor and case-matched normal tissue. In addition, the contractor shall sequence entire exomes, deposit the sequenced data according the TCG rapid data release policies, efficiently and accurately analyze the data to initially detect >80% of true mutations and polymorphisms and at the same time minimize the false positive discovery rate including complete analysis, and have an established and integrated bioinformatics capability sufficient to support production, including systems and database administration, laboratory information management, data handling and deposition. The Contractor shall meet the following milestones: sequence information on a minimum of 95% of the exomic targets for a minimum of 95% of the cases sequenced by the Contractor; sequencing data analyzed and aligned to a reference sequence and submitted to the public databases according to specifications provided by the Contractor within one (1) week of generation; a list of putative mutations that have been identified, prioritized (i.e. placed into bins relating to potential functional significance in whole genome studies) and submitted to the TCGA database within four (4) weeks of sequence generation - annotations of the analyzed data submitted to NCBI or NCI databases, including fields to be determined in consultation with NCI and other TCGA research groups. Request for Proposal (RFP) N02-CO-07005-65 will be available on/or about January 4, 2010 and receipt for proposals will be due on/or about 2:00 p.m., Eastern Prevailing Time on February 4, 2010. The RFP will only be available electronically and must be accessed through the National Cancer Institute's Office of Acquisitions external website (http://rcb.nci.nih.gov/); once there, click on Current Requests for Proposals. Under the Section entitled The Cancer Genome Atlas (TCGA) Project, click on solicitation number N02-CO-07005-65 entitled, "Sequencing for The Cancer Genome Atlas (TCGA) Program." Interested parties are expected to review this notice and the Request for Proposal to familiarize themselves with the requirements of the project; failure to do so will be at your firm's own risk. All information required for submission of a proposal will be contained in the electronic RFP package. POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE RFP AND ANY AMENDMENTS, FAILURE TO DO SO WILL BE AT YOUR FIRM'S OWN RISK. It is the offeror's responsibility to monitor the above website for the release of this RFP and amendments, if any. This solicitation is anticipated to result in approximately three (3) awards to offeror(s) capable of performing all aspects of the Statement of Work. The contract(s) shall be a cost-reimbursement (completion type) and will be awarded for an eighteen (18) month period of performance with option provisions to extend up to a five-year period of performance, to include optional quantities within the base period and each optional period. It is anticipated that the eighteen (18) month base period will be funded utilizing ARRA Funding. The option periods, if exercised will be supported by appropriated funds. All responsible and qualified sources may submit a proposal which shall be considered by the Government. This advertisement does not commit the Government to award a contract. No collect calls will be accepted. The North American Industry Classification System (NAICS) code for this project is 541380, with a size standard of $12.0 million. Point of Contact: C. Timothy Crilley, Contracting Officer, Treatment and Support Branch, P.O. Box B, 244 Miller Drive, Room 116A, Fort Detrick, Frederick, Maryland 21702-1201. If courier service is used, the address above is the same except delete P.O. Box B, 244 Miller Drive, Room 116A and replace with Building 244, Room 116A. The Contracting Officer can be reached at tcrilley@mail.nih.gov; telephone 301-228-4224 or facsimile 301-228-4240. Collect calls will not be accepted.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/FCRF2/N02-CO-07005-65/listing.html)
- Record
- SN02026662-W 20091219/091217235144-1183876140032ac2b34510ed194947a9 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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