SOLICITATION NOTICE
A -- Lung Tissue Research Consortium (LTRC): Tissue Repository
- Notice Date
- 12/23/2009
- Notice Type
- Presolicitation
- NAICS
- 541712
— Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NIH-NHLBI-HR-11-15
- Point of Contact
- LaMeshia Billington, Phone: 3014438763
- E-Mail Address
-
billingtonlr@nhlbi.nih.gov
(billingtonlr@nhlbi.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- The National Heart, Lung, and Blood Institute (NHLBI) is seeking a Tissue Repository (TR) for a four-year continuation of the multi-center Lung Tissue Research Consortium (LTRC). The purpose of this announcement is to provide a Presolicitation Notice for the release of the LTRC Solicitation NIH-NHLBI-HR-11-15. THIS IS A SYNOPSIS. THIS IS NOT A SOLICITATION. The overall objective of the LTRC is to enable better management of lung diseases by increasing understanding of the pathogenetic mechanisms of these diseases through studies of human lung tissues. The LTRC facilitates histopathological and molecular research of pulmonary diseases by collecting lung tissues from donors and preparing and distributing collections of tissue specimens to researchers within and outside the Consortium. Collections of specimens are linked to extensive, individual clinical and phenotypic data. The LTRC will consist of multiple Clinical Centers (CCs), a Radiology Center (RC), a Tissue Repository (TR), a Data Coordinating Center (DCC), and possibly, External Contributors through the DCC contract. The CCs will enroll subjects and perform extensive clinical phenotyping. The RC will perform quantitative analyses and archiving of high resolution chest computed tomography (CT) images. The TR will process tissues and prepare specimen collections in accordance with investigator requests. The DCC will manage the study and a central database, provide data quality assurance, and coordinate the review and approval of requests for tissues and data. External Contributors, if used, will submit data and biospecimens collected according to the LTRC protocol from individuals with specific, targeted conditions. The NHLBI anticipates one award under a Request for Proposal (RFP) for the Tissue Repository (TR). The TR will 1) obtain and maintain approval for TR activities described in the LTRC Protocol Manual; 2) provide one member of the Steering Committee (SC) with expertise in lung histopathology, who will participate fully in the activities of the SC; 3) conduct a training/retraining course for CC personnel involved in specimen handling and initial processing; 4) participate in site visits of CCs or institutions identified by the SC and NHLBI as potential External Contributors and assess the capability of the institutions to provide biospecimens in accordance with the LTRC Protocol; 5) process biological specimens received from CCs and possibly External Contributors, and perform quality control/quality assurance tests and report results to the DCC; 6) store specimens received using methods that preserve biospecimen integrity and scientific usefulness, and establish and maintain a system for tracking specimens received and samples stored and distributed; 7) perform histopathological analyses of lung tissue specimens received to obtain diagnostic and quantitative research measures of disease, and transmit results to the DCC; 8) perform diagnostic, light-microscopic, histopathological analyses of CC lung tissues by a board-certified pathologist, and notify the contributing CC of any clinically significant abnormalities; 9) prepare biological samples and sample collections for distribution to investigators for approved studies; 10) identify any problems with existing LTRC procedures and devise strategies to improve procedures; 11) deliver or ship all specimens and specimen collections remaining at the end of the contract period, together with the coded information needed to identify each sample by type and donor subject; 12) participate with other LTRC investigators in up to two collaborative clinical research substudies; and, 13) conduct approved research studies and disseminate the results and conclusions to the research community. This is not a request for proposal (RFP) and the Government is not committed to award a contract pursuant to this announcement. It is anticipated that the RFP will be available on FedBizOpps on or about January 8, 2010. This advertisement does not commit the Government to award a contract.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/NIH-NHLBI-HR-11-15/listing.html)
- Record
- SN02030988-W 20091225/091223235202-a93ab150919e5f92324753bd0e2d23ee (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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