SOLICITATION NOTICE
R -- Professional Services for the Post-Acquisition Image Processing and Analysis of Structural MRI Images
- Notice Date
- 4/26/2010
- Notice Type
- Presolicitation
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- NOI1567072
- Point of Contact
- Susan Nsangou, Phone: 3014432104
- E-Mail Address
-
nsangous@mail.nih.gov
(nsangous@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a notice of intent, not a request for a proposal. A solicitation document will not be issued and proposals will not be requested. The National Institute on Drug Abuse (NIDA), Station Support/Simplified Acquisition (SS/SA) Branch on behalf of the National Institute of Aging (NIA) intends to solicit, negotiate and award a purchase order on a noncompetitive basis to Jul Lea Shamy, 72 Seaman Avenue, New York, NY for the services for the study of age-related deficits in cognitive function which compromise the quality of life and are among the most troubling consequences of growing older. A major line of research in the Neurocognitive Aging Section (NAS) of the Laboratory of Experimental Gerontology is aimed at establishing a nonhuman primate model for defining the basis of normal cognitive aging. An important goal of these studies is to develop a detailed and sensitive framework for testing the working hypothesis that age-related decline results from large-scale restructuring of the neural networks that support normal memory. Toward this end, subjects receive periodic high resolution, structural MRI and corresponding [18F]fluorodeoxyglucose (FDG) PET scans, over the course of neuropsychological testing. Metabolic activity in the prefrontal cortex and medial temporal lobe system is then evaluated in relation to individual variability in the cognitive outcome of aging. The imaging data are also subject to Statistical Parametric Mapping (SPM) analysis, providing a nonbiased, whole-brain mapping of age-related metabolic change. As part of her Ph.D. research, Dr. Jul Lea Shamy conducted several novel in vivo brain imaging studies utilizing our nonhuman primate model of cognitive aging. Key findings included the observation that the volume of the hippocampus is largely preserved under conditions where the confounding influence of neurodegenerative disease can be excluded, even among subjects with documented deficits in hippocampal memory function (Shamy et al., 2006). By comparison, certain signatures of cognitive aging in monkeys appear associated with broader, network scale alterations distributed across multiple memory-related brain regions (Alexander et al., 2008). Ongoing NAS studies require this established expertise in imaging analysis in nonhuman primate models of cognitive aging. In this project Dr. Shamy will perform post-acquisition image processing and analysis of structural MRI images from behaviorally characterized young and aged monkeys. This analysis may include both region-of-interest and voxel-based approaches for identifying brain markers of normal cognitive aging. The MRI scans will also provide anatomical localization for FDG PET data, providing a reflection of potential metabolic change in the aged brain. Dr. Shamy has extensive expertise in image analysis in relation to cognitive aging in the monkey, and her support will be critical to the success of our ongoing studies. Dr. Shamy has conducted this services and published this data in journals including Neurobiology - Aging. Dr. Shamy will conduct project analyses using facilities available to her at the Mount Sinai School of Medicine, and she will make two trips to the NIA-IRP at the Biomedical Research Center in Baltimore, or the NIH Animal Center in Poolesville, MD for project progress reports and coordination. The anticipated period of performance is May 15, 2010 thru May 14, 2011. It is anticipated to be 16 hours per week. The acquisition is being conducted under simplified acquisition FAR 13 and is exempt from the requirements of FAR Part 6, Competition Requirement. This notice of intent is not a request for competitive proposals. Interested parties may identify their interest and capabilities in response to this synopsis. The determination by the Government not to compete the proposed contract based upon responses to this notice is solely with the discretion of the Government. Comments to this announcement, referencing synopsis number NOI1567072 may be submitted to the NIDA, SS/SA Branch, 31 Center Drive, Room 1B59, Bethesda, MD 20892, Attention: Susan Nsangou
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/NOI1567072/listing.html)
- Record
- SN02132160-W 20100428/100426234859-f2259fb8e7dfac3efc4513b4efef20bd (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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