SOLICITATION NOTICE
70 -- Intend to Sole Source Renewal of Genedata Screener and Hit Profiler Software
- Notice Date
- 4/29/2010
- Notice Type
- Presolicitation
- NAICS
- 541511
— Custom Computer Programming Services
- Contracting Office
- Environmental Protection Agency, Office of Acquisition Management, RTP Procurement Operations Division, E105-02, 4930 Old Page Road, Research Triangle Park, North Carolina, 27703
- ZIP Code
- 27703
- Solicitation Number
- RFQ-RT-10-000157
- Archive Date
- 5/25/2010
- Point of Contact
- Pamela E. Smith, Phone: 919.541.0635
- E-Mail Address
-
smith.pamela@epa.gov
(smith.pamela@epa.gov)
- Small Business Set-Aside
- N/A
- Description
- The U.S. Environmental Protection Agency (EPA) intends to negotiate a sole source purchase order under Simplified Acquisition Procedures to Genedata (USA), Inc. One Cranberry Hill, Suite 304, Lexington, MA 02451 for the renewal of a 1 year license for Genedata Screener and Hit Profiler Software. The National Center for Computational Toxicology (NCCT) requires a database and tools that must have the following capabilities: (1) Flexibility in building templates for calculation of raw plate based data; (2) Visualization of plate based data for QC analysis; (3) Robust concentration response curve fitting routine; (4) Ability to link chemicals in sample plates to assay results; (5) Operational database supporting mass storage of data and analysis results. A large amount of data for ToxCast will be generated at the National Institutes of Health, Chemical Genomics Center (NCGC). Their unique approach to HTS, termed quantitative HTS (qHTS), tests all chemical in concentration response format. This presents unique challenges in data QC and management. Curve fitting routines must be extremely robust to routinely and efficiently handle thousands of test results. This is an absolutely critical step in the qHTS data from NCGC. In addition, other products have laborious procedures required to build specific templates for calculating raw data for HTS assays. Because ToxCast will be acquiring data from a number of different sources and for a large number of different assays (hundreds), the ability to easily build templates for data calculation sophisticated visualization of plate based data, an interface to link sample information with assay results, and an operational database sufficient to meet the long term requirements of the ToxCast Program. Genedata Screener hit Profiler is a software application that provides access to the heterogeneous research data that make up the ToxCast and Tox21 toxicity screening results in an easy-to-use interactive environment. It is an extension of the Genedata Screener database system currently be use to process all concentration-response data and to provide QC analysis on some of the single-concentration screening data. The Hit Profiler offers unique capabilities for data visualization and efficient filtering and reporting results Biological activity including potency determination and associated statistics, chemical structure and properties and additional data can be brought together and compared across biological targets. This offers an important view of the bioactivity profiles of chemicals of interest. Hit Profiler is currently being used by NCCT and has produced robust performance. Thousands of chemical have been examined across up to 12 biological targets without problems. This is sufficient for the need of the ToxCast and Tox21 screening efforts. There are no other products on the market that will integrate with the Genedata Screener database to access these concentration-response curves. Visualization of these curves is a very important component in interpreting the biological significance of the results. The EPA has identified Genedata (USA), Inc., the only vendor capable of satisfy the requirement. In order to ensure data compatibility and accuracy. The circumstance permitting 'other than full and open competition' is FAR 6.302-1, Only one Responsible Source'. The intent of this notice is to determine if any other source(s) exist, and therefore, no solicitation (RFQ) is available. Consequently, any response failing to provide the aforementioned data and instead choosing to merely submit a routine letter requesting a copy of the RFQ will be ignored. Interested parties who can meet the above requirements may submit written qualification statements, fully explaining their capability no later than 4:30pm EST, May 10, 2010. Submit response to the U.S. EPA, Attn: Pamela E. Smith (MC E105 02), RTP Procurement Operations Division, Research Triangle Park, NC 27711. No telephonic or faxed request will be honored.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/EPA/OAM/CMD/RFQ-RT-10-000157/listing.html)
- Record
- SN02136149-W 20100501/100429235130-3c81decb14db25febb5d45979425f596 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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