SOURCES SOUGHT
A -- Toxicogenomics Database and Tissue Library
- Notice Date
- 6/25/2010
- Notice Type
- Sources Sought
- NAICS
- 541711
— Research and Development in Biotechnology
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, Office of Acquisitions, Office of Management, 530 Davis Drive, Durham, North Carolina, 27713, United States
- ZIP Code
- 27713
- Solicitation Number
- NIHES2010JAL
- Archive Date
- 7/7/2010
- Point of Contact
- JoAnn K Lewis, Phone: 919-541-7894
- E-Mail Address
-
lewisj@niehs.nih.gov
(lewisj@niehs.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Introductory Paragraph This is a Research and Development (R&D) Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential R&D requirement. Background The National Toxicology Program (NTP), an interagency program headquartered at the National Institute of Environmental Health Sciences (NIEHS), is a recognized leader in toxicology testing and research. The program provides a focal point within the federal government for the toxicological testing of chemical and physical substances to identify potential hazards for human health and for the development of improved testing methods. In 2004, the NTP released a roadmap for the 21st century providing a framework that would support an advancement in toxicology testing toward the development and use of new approaches, many focused on cellular and molecular strategies, which could potentially improve the predictability of toxicological data for assessing human health. Subsequently, in 2007, the National Research Council published its report, Toxicity Testing in the 21st Century: A Vision and A Strategy, which addresses the need for new testing approaches based on the identification of perturbations in key biological pathways. In carrying out its roadmap, the NTP's assessment of current and new methods for its toxicity testing strategy focuses on key biological pathways relevant for understanding human susceptibility to toxicity and disease. Thus, having an established source of toxicogenomic data and associated tissues would potentially accelerate its roadmap activities and contribute significantly to the evolution of toxicology testing. Purpose and Objectives The purpose of this requirement is to obtain an established toxicogenomic database and tissue library. Project Requirements Critical Features of Toxicogenomics Database and Tissue Library: 1. Database must include: a. a graphics user interface that allows for rapid scoring of genomic signatures of toxicity b. a framework that allows the storage and analysis of multiple data types c. In vivo study data must: (i) be from male Sprague Dawley rats, (ii) include multiple dose levels and exposure durations (1, 3, 5,7, 14, 30 and/or 90 days), (iii) (with the exception of bioactive peptides) be performed via the oral route of administration (gavage dosing). In the case of peptides, it is acceptable that the test article be administered by injection. (iv) be from a diversity of chemical treatments (a minimum of 600 distinct chemical entities) including, but not limited to US Federal Drug Administration (FDA) approved drugs, standard biochemicals, and environmental toxicants (v) Specific in vivo data metrics should include: (a) histopathology (on all tissues which were evaluated by microarray), (b) clinical chemistry, (c) hematology, (d) body and organ weights, and (e) gene expression (microarray) profiles of liver (>300 of the test articles), kidney (>200 of the test articles), heart (>200 of the test articles), thigh muscle (>10 of the test articles), bone marrow (>50 of the test articles), spleen (>30 of the test articles), brain, and intestine. d. In vitro data must include pharmacology assays for toxicologically relevant endpoints (listed below) for all chemicals (with the exception of in vitro rat hepatocyte genomic studies) studied in vivo (rat): (i) receptor binding, and (ii) absorption, distribution, metabolism, and excretion (iii) it is estimated that >100 assays would be required to adequately address all toxicologically relevant endpoints alluded to in (i) and (ii). (iv) toxicogenomic (microarray) studies of cultured rat primary hepatocytes with >100 distinct test articles (must overlap with test articles evaluated in vivo studies described above) e. Drug literature profiles for all chemicals listed in the database. Specifically, the descriptions should include, but not be limited to, chemical pharamacology, toxicology, structure, and associated molecular pathways. 2. Rodent Tissue Library should include: (i) snap frozen tissue and corresponding total RNA from liver, heart, kidney, skeletal muscle, whole blood (or plasma) from rats treated with a minimum of 600 test articles including, but not limited to FDA approved drugs, standard biochemicals and environmental toxicants. (ii) tissues/RNA must be from the same Sprague Dawley rats used to create the associated toxicogenomics database described above. Anticipated Delivery Period Delivery for the Toxiogenomics Database and Tissue Library is within 60 days from date of award. Information Sought Interested organizations are required to submit five (5) hard copies of their capability statement, not to exceed fifteen (15) pages in length; not including a standard product brochure that clearly details the ability to perform the aspects of the notice described above and should be tailored to the "Project Requirements" as concise as possible. Electronic capability statements must be in Word for Macintosh and PCs. Each response should also include the following business information. a. DUNS number b. Organization Name c. Company Address d. Point of Contact (including name, title, addresses, telephone number, fax number and Email address) e. Business size f. Socio-economic status g. Teaming Agreements (if necessary) Standard product brochures will not be considered a sufficient response to this sources sought synopsis. All information must be received at the NIEHS no later than Tuesday, July 6, at 3:00 PM, EST. Mail information to: Jo Ann Lewis, Contracting Officer, National Institute of Environmental Health Sciences, Office of Management, Office of Acquisitions, P.O. Box 12874, RTP, NC 27709. For express delivery, send to: Jo Ann Lewis, Contracting Officer, National Institute of Environmental Health Sciences, Office of Management, Office of Acquisitions, 530 Davis Drive, Morrisville, NC 27560. Telephone number: (919) 541-7894. Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIEHS/NIHES2010JAL/listing.html)
- Place of Performance
- Address: To be determined, United States
- Record
- SN02189198-W 20100627/100625235441-ce0969ab6dce02633ebc57e97e1b6a93 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |