SPECIAL NOTICE
B -- Assessment of the Indirect Benefits of the Rotavirus Vaccination Program in Atlanta
- Notice Date
- 6/28/2010
- Notice Type
- Special Notice
- NAICS
- 611310
— Colleges, Universities, and Professional Schools
- Contracting Office
- Department of Health and Human Services, Centers for Disease Control and Prevention, Procurement and Grants Office (Atlanta), 2920 Brandywine Road, Room 3000, Atlanta, Georgia, 30341-4146
- ZIP Code
- 30341-4146
- Solicitation Number
- 00HCVGEB-2010-86277
- Archive Date
- 7/9/2010
- Point of Contact
- Linda M Young, Phone: (770) 488-2655
- E-Mail Address
-
lml3@cdc.gov
(lml3@cdc.gov)
- Small Business Set-Aside
- N/A
- Description
- The Centers for Disease Control and Prevention intends to issue a sole source purchase order to Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310-1458, for Assessment of the Indirect Beneifits of the Rotavirus Vaccination program in Atlanta. The Statement of Work for this requirement is as follows: Rotavirus is the most common cause of severe diarrhea among US children <5 years of age, resulting in approximately 20 to 60 deaths, 55,000 to 70,000 hospitalizations, 272,000 emergency department visits, and 410,000 physician visits per year for children in this age group. By the age of 5 years, almost every child in the US has been infected with rotavirus. In 2006, a pentavalent rotavirus vaccine (RotaTeq – Merck Vaccines, Whitehouse Station, NJ) was recommended for use among US infants and in 2008, a second rotavirus vaccine (Rotarix –GlaxoSmithKline Biologicals, Rixensart, Belgium) was recommended for use in infants. Surveillance for rotavirus gastroenteritis is currently being conducted among several sentinel hospitals in the United States as part of a public health program evaluation of the impact of rotavirus vaccination. Surveillance data collected during 2007-2008 from three surveillance sites in the United States and data from national hospital and office databases demonstrated significant reductions in the number of rotavirus hospitalizations compared prevaccine seasons. These reductions were greater in magnitude than expected for the level of vaccine coverage at the time, with the greatest impact among children 1-3 years of age, many of whom were age-ineligible to have received rotavirus vaccine. This suggests an indirect benefit of vaccination on disease burden, possibly through reduction of transmission to susceptible contacts within the household and/or community. To date, no known studies have examined the potential indirect benefits of rotavirus vaccination. A case-control study assessing the effects of vaccination in susceptible, non-vaccinated household contacts in Atlanta, a location that has predominantly used Rotarix most recently, will provide a better understanding of the public health impact of rotavirus vaccination on disease burden. The purpose of this project is to evaluate the indirect benefit of rotavirus vaccination among Atlanta children. Scope of work is as follows: the contractor shall enroll eligible children into the evaluation at two Children’s Healthcare of Atlanta (CHOA) hospitals following standardized procedures, obtain stool sample on enrolled children and complete all evaluation forms for each enrolled child. The possible indirect effects of the rotavirus vaccine program will be assessed by comparing the rotavirus vaccine status of households of rotavirus cases to the vaccine status of control households. The control households will be those where a child had diarrhea that was found to not be due to rotavirus (rotavirus-negative). Cases and controls will be children who did not themselves receive rotavirus vaccine. Children who present to ED or are hospitalized for diarrhea as the main or one of the main reasons for the visit who are aged 2.5 years up through age 4 years (before 5th birthday) and have at least one other child in the household who is aged <5 years (before 5th birthday) will be approached for enrollment. The parent/guardian will be asked to participate in the study and informed consent will be obtained. For the case child with diarrhea, a questionnaire will be completed, stool sample will be obtained and tested for rotavirus, and information on this diarrheal illness will be obtained from the case child’s medical record. For all other young (age <5 years) household members, consent to obtain immunization records will be obtained and parent will be asked if the child also had diarrhea. Immunization records will be obtained from the providers and from the state immunization registry on the case child and the young household members who have DOB 3/1/2006 or later. Screening logs documenting enrollment success rate will also be maintained. A formatted electronic database will be provided to the contractor within 15 days of issuance of order. The period of performance shall be eight months from date of award. Deliverables provided from this requirement will be: a. monthly progress reports provided by the contractor showing the work completed the previous month. Contractor shall clearly indicate the level of effort expended. The monthly progress report shall be provided to the Project Office along with a copy of the contractor’s monthly invoice. b. The contractor shall deliver the electronic database that contains the data from the screening logs, parent questionnaires, household member questionnaires, medical record reviews, provider immunization data and registry immunization data within 6 months of the issuance of the order. The contractor shall follow institutional requirements to ensure appropriate privacy safeguards during data collection efforts. Data generated under the contract will become and remain the property of the Government and may not be disseminated or otherwise released without the advance written permission of the CDC Project Officer in accordance with CDC Data Sharing/Data Release Guidelines. CDC believes that this requirement is met by only one provider. This procurement will be processed under the authority of FAR 6.302-1 and 6.302-2. Only one responsible source and no other sources will satisfy agency requirements. No solicitation is being issued. Interested persons may identify their interest and capability to respond to this requirement. This procurement is not set-aside for small business. For contractual questions contact Linda M. Young.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/CDCP/PGOA/00HCVGEB-2010-86277/listing.html)
- Place of Performance
- Address: 1600 Clifton Road, Building 16, Atlanta, Georgia, 30333, United States
- Zip Code: 30333
- Zip Code: 30333
- Record
- SN02190345-W 20100630/100628235335-e16cd4940b122f7c973a6c2fbef77f62 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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