SPECIAL NOTICE
A -- TECHNOLOGY/BUSINESS OPPORTUNITY Lawrence Livermore Microbial Detection Array (LLMDA)
- Notice Date
- 7/23/2010
- Notice Type
- Special Notice
- NAICS
- 238990
— All Other Specialty Trade Contractors
- Contracting Office
- Department of Energy, Lawrence Livermore National Laboratory (DOE Contractor), Industrial Partnerships & Commercialization, 7000 East Avenue, L-795, Livermore, California, 94550
- ZIP Code
- 94550
- Solicitation Number
- FBO223-10
- Archive Date
- 8/24/2010
- Point of Contact
- Connie L Pitcock, Phone: 925-422-1072
- E-Mail Address
-
pitcock1@llnl.gov
(pitcock1@llnl.gov)
- Small Business Set-Aside
- N/A
- Description
- TECHNOLOGY/BUSINESS OPPORTUNITY Lawrence Livermore Microbial Detection Array (LLMDA) Opportunity : Lawrence Livermore National Laboratory (LLNL), operated by the Lawrence Livermore National Security (LLNS), LLC under contract with the U.S. Department of Energy (DOE), is offering the opportunity to license and develop the Lawrence Livermore Microbial Detection Array (LLMDA) technology. Background : Emerging known and unknown pathogens create profound threats to public health. Platforms for rapid detection and characterization of microbial agents are critically needed to prevent and respond to disease outbreaks. E xisting detection technologies are based on nucleic acid amplification of sequences from one or a small set of organisms. While they are able to rapidly identify selected pathogens at the species or strain level, they cannot be multiplexed to the degree required to detect hundreds to thousands of different organisms. Description : Lawrence Livermore National Laboratory's scientists have developed the Lawrence Livermore Microbial Detection Array (LLMDA), a technology enabling detection of bacteria, viruses and other organisms. This technology has shown value for applications in detection for product safety, diagnostics and bioterrorism events. LLMDA contains probes fitted onto a one-inch by three-inch glass slide. Each probe tests for a particular sequence of DNA and small groups of probes can be used to check for specific bacteria or viruses up to the species level. The LLMDA can test for over 2,000 viruses and 900 bacteria. The newer version of the LLMDA will expand that capability to nearly 6,000 viruses and 15,000 bacteria as well as fungi and protozoa organisms. After DNA and/or RNA is extracted from a sample, it is applied to the LLMDA. Any probe that detects its specific sequence will fluoresce, and be read by a scanner. The raw data from the scanner is then analyzed using algorithms developed by LLNL run on high performance computing (HPC) machines. Bioinformatics is used in identifying the large numbers of nucleic acid sequences, or probes, which are the signatures of microbes. LLNL has developed software to design probes from genomic data. High performance computers at LLNL play a crucial role in meeting the extensive requirements of designing these probe sequences and updating them regularly. Advantages : •· Rapid and comprehensive detection of viruses, bacteria and fungi. •· The designed probes can be used on various microarray platforms that support long probes, such as from Roche NimbleGen and Agilent Technologies. •· Custom probe sets can be designed (and further developed). •· High performance computing enables the bioinformatics and data processing required for designing probes and analyzing data from the comprehensive arrays. Applications : LLMDA has a wide variety of potential applications: •· Public Health •· Animal and Crop Health •· Homeland Security •· Food/Product Safety •· Force Protection •· Forensics •· Molecular Diagnostics Publications : •· Collaboration with the Marine Mammal Center to identify potential causes of death of sea lions and seals was featured on Channel 2 KTVU News, June 2010. (The transcript can be read at http://www.livedash.com/transcript/news_at_5pm/7/KGO/Friday_June_11_2010/231796/ ) •· Viral nucleic acids in live-attenuated vaccines: detection of minority variants and an adventitious virus. Victoria JG, Wang C, Jones MS, Jaing C, McLoughlin K, Gardner S and Delwart EL. J. Virol. 84: 6033-40, http://jvi.asm.org/cgi/reprint/84/12/6033, 2010. •o This work was featured on KGO-TV San Francisco, CA, ABC Channel 7 News, April 2010. http://abclocal.go.com/kgo/story?section=news/drive_to_discover&id=7392943 •· A functional gene array for detection of bacterial virulence elements. JAING C, Gardner S, McLoughlin K, Mulakken N, Alegria-Hartman M, Banda P, Williams P, Gu P, Wagner M, Manohar C, and Slezak T. PLoS ONE, http://www.plosone.org/doi/pone.0002163, 2008. •· A Microbial Detection Array (MDA) for Viral and Bacterial Detection, Gardner SN, Jaing CJ, McLoughlin KS, Slezak TR, submitted to BMC Genomics •· Patent application: Biological sample target classification, detection and selection methods, and related arrays and oligonucleotide probes, Gardner SN, Jaing CJ, McLoughlin KS, Slezak TR., filed Dec 09, 2009. Development Status : LLNL has developed the probes for the microarray and the software to analyze the microarray data, and is looking for partners to license as well as partners to develop additional capabilities. LLNL is seeking industry partners with a demonstrated ability to bring such inventions to the market. Moving critical technology beyond the laboratory to the commercial world helps our licensees gain a competitive edge in the marketplace. All licensing activities are conducted under policies relating to the strict nondisclosure of company proprietary information. Please visit the IPO website at http://ipo.llnl.gov/workwithus/partneringprocess.php for more information on working with LLNL and the industrial partnering and technology transfer process. Note: THIS IS NOT A PROCUREMENT. Companies interested in commercializing LLNL's Microbial Detection Array (LLMDA) should provide a written statement of interest, which includes the following: 1. Company Name and address. 2. The name, address, and telephone number of a point of contact. •3. A description of corporate expertise and facilities relevant to commercializing this technology. Written responses should be directed to: Lawrence Livermore National Laboratory Industrial Partnerships Office Attn: Ida C. Shum P.O. Box 808, L-795 Livermore, CA 94551-0808 Attention: FBO 223-10 Please provide your written statement within thirty (30) days from the date this announcement is published to ensure consideration of your interest in LLNL's technology.
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