SOLICITATION NOTICE
Q -- Services regarding the metabolomic analysis of nested-case control studies in the Alpha-Tocopherol Beta-Carotene (ATBC) cancer prevention study, and people exposed to trichloroethylene
- Notice Date
- 7/27/2010
- Notice Type
- Presolicitation
- NAICS
- 541380
— Testing Laboratories
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-100146-AV
- Archive Date
- 8/26/2010
- Point of Contact
- Ashley L. Virts,
- E-Mail Address
-
virtsa@mail.nih.gov
(virtsa@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- The National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), Occupational and Environmental Epidemiology Branch (OEEB) plans to procure on a sole source basis with Emory University, 4131 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322 for services regarding the metabolomic analysis of nested-case control studies in the Alpha-Tocopherol Beta-Carotene (ATBC) cancer prevention study, and people exposed to trichloroethylene. The supplies and services herein are being procured in accordance with the simplified acquisition procedures as authorized by FAR Part 13.106 (b)(1). The North American Industry Classification System code is 541380 and the business size standard is $12M. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. Period of Performance shall be for twelve (12) months from date of award. The etiology of lymphoma is a complex process with genetic and environmental risk factors. Extensive research has been conducted on the environmental and genetic determinants of lymphoma throughout the West. Major environmental risk factors for lymphoma are chemical exposures, such as organochlorines, trichloroethylene and benzene. Genetic associations have also been identified, and replicated, as determinants of lymphoma (i.e. IL10 and TNF). A metabolomics approach to disease etiology identifies a collection of metabolites within a subject, reflecting both genetic and environmental factors. Therefore, metabolomics provides an integrated picture of the interactions of environmental exposures within an individual's genetic profile. Further, metabolomic profiling can identify which pathways are associated with the development of a particular cancer, and provide the basis to separate and identify contributing genetic and environmental factors. The ATBC study is ideal for a metabolomic analysis as the samples are prospectively collected with detailed covariate data, providing the opportunity to be the first study to explore metabolic profiles of lymphoma cases and controls. Therefore, under this requirement, the contractor will carry out a metabolomic analysis in a nested case-control study of lymphoma, as well as an analysis of subjects included in each intervention arm, within the ATBC study. In addition, the contractor will also evaluate the metabolic profiles of subjects occupationally exposed to trichloroethylene. The laboratory of Professor Dean Jones at Emory University developed the liquid chromatography-Fourier transform mass spectrometry (LC-FTMS) method for discovery-based metabolomic profiling and is the only laboratory in the medical literature that has published the capability of performing this assay. The LC-FTMS method uses a validated analytic platform in combination with the adaptive processing of high-resolution LCMS data (apLCMS) method to detect 2,500 metabolites at low concentrations (μM to low nM range) in plasma samples. The capabilities depend upon the high mass resolution and mass accuracy of the FTMS. FTMS uses ion cyclotron resonance (ICR) in a high-field electromagnet to provide mass resolution and mass accuracy to predict elemental composition for low molecular mass biological metabolites. Analytes are identified in terms of the highly accurate mass-to-charge (m/z) ratio and, for most of the ions detected, elemental compositions can be predicted. This method is preferred because it uses the high mass resolution and mass accuracy of the FTMS to predict the elemental composition for low molecular mass metabolites. This is an advantage over other approaches because the metabolites can be resolved and quantified without extensive chromatographic separation or ion fragmentation. By combining this analysis with targeted measures of key reference metabolites, which make up about 65% of metabolites analyzed, a detailed understanding of the metabolic differences between cases and controls can be determined. Dr. Dean Jones is a world expert in metabolomic analysis; his laboratory at Emory University is currently the only facility that can perform this assay with high throughput and reproducibility, and is therefore uniquely qualified to conduct the metabolomic analysis under this requirement. This notice is not a request for competitive quotation. However, if any interested party believes it can meet the above requirement, it may submit a statement of capabilities. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Capability statements must be received in the contracting office by 11:00 AM EST, on August 11, 2010. For further information, please contact Ashley Virts, Contract Specialist via electronic mail at virtsa@mail.nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. No faxed or emailed capability statements will be accepted. In order to receive an award, contractors must be registered and have valid certification in the Central Contractor Registration (CCR) and the Online Representations and Certifications Applications (ORCA). Reference: NCI-100146-AV on all correspondence.
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- Record
- SN02219533-W 20100729/100727235900-9f8972144daee2cbec12e12ca0a0c426 (fbodaily.com)
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