SOLICITATION NOTICE
B -- Raman Spectroscopy to Characterize Differences between Luminal A and Basal Breast Cancers
- Notice Date
- 4/5/2011
- Notice Type
- Presolicitation
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-110054-TG
- Archive Date
- 5/5/2011
- Point of Contact
- Terry Galloway, Phone: 301-402-4509, Caren N Rasmussen, Phone: (301) 402-4509
- E-Mail Address
-
gallowaytl@mail.nih.gov, cr214i@nih.gov
(gallowaytl@mail.nih.gov, cr214i@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Contracting Office Address Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Boulevard, EPS Suite 600, Room 6074, Rockville, MD 20852, UNITED STATES. Description The National Institutes of Health (NIH), National Cancer Institute (NCI), intends to procure on a sole-source basis with Wayne State University, College of Engineering, 5050 Anthony Wayne Drive, Detroit, MI 48202 to characterize and map the Raman signature of 88 frozen tissue specimens collected in the Polish Women's Health Study. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-(b)(1). The North American Industry Classification System Code is 541990 and the business size standard is $7.0 million. Period of performance: Performance shall be for twelve (12) months from date of award. Only one (1) firm fixed price type contract will be awarded. The National Cancer Institute (NCI) Division of Cancer Epidemiology and Genetics (DCEG) investigators have made advances in the study of breast cancer etiology and considerations of new strategies for prevention and treatment through and increased understanding of differences in risk factors and biology between breast cancer subtypes. Recently, several studies have shown that molecular differences in tumor tissues between subtypes are mirrored in benign tissues surrounding these tumors. Amassing data strongly suggest that the breast microenvironment (i.e. stromal - epithelial interactions) influences both the risk of breast cancer and the biological, molecular and clinical characteristics of tumors that develop. The objective of this procurement is to characterize and map the Raman signature of 88 frozen tissue specimens collected in the Polish Women's Health Study using an internal standard to enable peak height quantification. Specifically, the NCI will assess paired samples of cancer and non-cancer tissues from 44 women, including 22 with basal cancers and 22 with luminal A tumors defined by mRNA profiling, matched on age and grade. These data will be compared to gene expression profiles of the matched tissues, other pathology data and information about risk factors and survival. Wayne State University has vast experience applying Raman spectroscopy to human tissues and has published findings related to this work, which include analysis of tissues adjacent to breast cancer. In addition, the laboratory possesses special capabilities include multi-wavelength Raman technology, mapping techniques and unique processing and analytical algorithms. In addition, the contractor's staffing is adequate to perform the extensive tasks of this contract within a one-year timeframe, and includes the ability to interact with pathologists and molecular pathologists within the institution as needed. The contractor's laboratory has previously demonstrated the feasibility of Raman characterization of frozen tissues from the Polish Study. Dr. Auner, Program Director, Smart Sensors and Integrated Microsystems (SSIM) Program, Wayne State University, College of Engineering has developed and validated many Raman signatures in both rodent and human tissues, including cell tumors of childhood, lymphomas, myc gene amplification, T cell activation, matrix metalloproteinases, methicilinn resistant Staphylococcus aureus and strains of HIN influenza virus. Wayne State University possess a unique combination of expertise, experience, equipment, staff and Raman database required to complete this work rapidly within timeframe and budget. This is not a solicitation for competitive quotations. However, if any interested party believes it can meet the above requirement, they may submit a statement of capabilities. All information furnished shall be in writing and must contain sufficient detail to allow the NCI to determine if it can meet the above unique specifications described herein. An original and one copy of the capability statement must be received in the NCI contracting office by 11:00 AM EST on April 20, 2011. All questions must be in writing and can be faxed (301) 402-4513 or emailed to Terry Galloway, Contract Specialist at gallowaytl@mail.nih.gov. It is the vendor's responsibility to call (301) 402-4509 to verify questions have been received. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must have valid registration/certification in the Central Contractor Registration (CCR) www.ccr.gov and the Online Representations and Certifications Applications (ORCA), http://orca.bpn.gov. No collect calls will be accepted. Please reference NCI-110054-TG all correspondence.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/RCB/NCI-110054-TG/listing.html)
- Record
- SN02417723-W 20110407/110405235124-ec385ab25c61048345082616db54bfb9 (fbodaily.com)
- Source
-
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