SPECIAL NOTICE
99 -- Animal Models of Parkinson's Disease Study
- Notice Date
- 5/5/2011
- Notice Type
- Special Notice
- NAICS
- 611310
— Colleges, Universities, and Professional Schools
- Contracting Office
- National Institutes of HealthNational Institute on Drug AbuseBethesdaMD20892-7511
- ZIP Code
- 20892-7511
- E-Mail Address
-
LINDSAY, CAROL A
(clindsay@intra.nida.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a notice of intent, not a request for a proposal. A solicitation document will not be issued and proposals will not be requested. The National Institute on Drug Abuse (NIDA), Intramural Research Program (IRP) intends to solicit, negotiate and award a purchase order on a noncompetitive basis with Karolinska Institute, Department of Neurobiology, Retzius v. 8, B2:4, Stockholm, Sweden S-171 77. The National Institutes on Drug Abuse (NIDA), Division of Intramural Research in Baltimore, Maryland requires specialized skills, expertise, facilities and equipment to be able to do the very specific research needed. Objectives The objectives of this contract is to provide the NIDA IRP with further characterization of mito Park mice as pertaining to the ongoing IRP research effort into the nature of drug abuse and addiction. It has been determined that the original mouse animal model carries a dopamine neuron-specific deletion of the mtDNA transcription factor TFAM. This characterization will be determined via the following procedures as performed by the contractor: Development of transgenic mice with midbrain DA neuron mitochondria labeled with yellow fluorescent protein (YFP) Crosses of YFP mice and MitoPark mice Further studies of neuropathological events in dopamine neurons of the YFP mitoPark mice Effects of exercise in this animal model Specific Requirements Generation of transgenic mice in which the mitochondria of midbrain DA neurons are specifically labeled with yellow fluorescent protein (YFP). Evaluation of these mice by motor behavior, immunocytochemistry and biochemistry. Crosses of the YFP mice with MitoPark mice to obtain YFP labeling of midbrain DA mitochondria in TFAM deficient neurons. Studies of neuropatholgical events in the dopamine neurons of YFP mitoPark mice at the cell body and terminal level using this genetically engineered marker to identify only the mitochondria of dopamine neurons. Investigations into the effect of exercise on the animal model to determine if early initiation of exercise can alter the neurodegenerative events Karolinska Institute recently successfully developed fluorescent mitochondria transgenic with expression restricted to midbrain dopamine neurons. No other laboratory in the world has all these techniques and resources in one site as well as a large mito Park colony. The acquisition is being conducted under simplified acquisition FAR 13 and is exempt from the requirements of FAR Part 6, Competition Requirement. This notice of intent is not a request for competitive proposals. Interested parties may identify their interest and capabilities in response to this synopsis. The determination by the Government not to compete the proposed contract based upon responses to this notice is solely with the discretion of the Government. Comments to this announcement, referencing synopsis number NIHDA2011196 may be submitted to the NIDA, IRP, 251 Bayview Boulevard, Suite 200, BRC Bldg., Rm 04A326, Baltimore, MD 21224, ATTN: Carol Lindsay by May 16, 2011.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/notices/0a7cb202a9ff92b1c74b5b2e866d2a95)
- Record
- SN02441065-W 20110507/110505234743-0a7cb202a9ff92b1c74b5b2e866d2a95 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |