SPECIAL NOTICE
66 -- Acquisition of Asymmetrical Low Field-Flow Fractionation (AF4) Detector System Upgrade
- Notice Date
- 8/18/2011
- Notice Type
- Special Notice
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, Centers for Disease Control and Prevention, Spokane Research Laboratory, 315 East Montgomery Avenenue, Spokane, Washington, 99207
- ZIP Code
- 99207
- Solicitation Number
- 00HCUGDH-2011-00633
- Archive Date
- 9/17/2011
- Point of Contact
- Denise L Rains, Phone: 509-354-8111
- E-Mail Address
-
dgr8@cdc.gov
(dgr8@cdc.gov)
- Small Business Set-Aside
- N/A
- Description
- NOTICE OF INTENT TO ISSUE A PURCHASE ORDER. The Centers for Disease Control and Prevention, National Center for Environmental Health (NCEH), Emergency Response and Air Toxicants Branch, Division of Laboratory Science, hereby announces its intent to issue a purchase order to Postnova Analytics for the Light Detector S-DET-3704-001, Laser Light Detector S-DET-3607-001, and RI Detector S-DET-3150-001, upgrades to the flow fractionation (AF4) instrument, previously purchased from Postnova, being used for analysis of large apolipoproteins and lipoprotein particles. Postnova has the patented technology necessary to focus on protein samples for concentration measurement purposes, and a multi-pump system to achieve high resolution and robustness. The symmetric Flow Field Flow Fractionation (a4F) instrument separates low density lipoproteins (LDLS) into small sub-fractions. Postnova detector upgrades will unify with the software which is part of the existing AF4 system. The size of the flow cells in the Postnova detectors are optimized for the Postnova AF4 system. The system upgrade will provide the required detector upgrades to the current system and integrate with the operation of the Postnova AF4 system. Physicochemical characterization of lipoprotein particles is used for diagnosis of cardiovascular disease. Apolipoproteins are much stronger risk predictors than the traditional cholesterol and triglyceride content based diagnostics methods. The detector upgrade package is necessary to expand capabilities to determine apolipoproteins in lipoprotein particle fractions (LDL, sub-LDL, and HDL). The upgrade is necessary for molecular weight/size/concentration measurements of large apolipoproteins and lipoprotein particles. The upgrade consists of the purchase of three types of detectors: DL Zetasizer S173 dynamic light scattering detector, which will determine particle size determination based on Brownian motion of the molecules; the PN3607-MALS multi-angle light scattering detector that measures molar mass based on the rate of gyration and detects conformational differences between particles; and the PN3150 RI (Refractive Index) Detector, which is a universal detector that measures concentration of the particles based on light refraction. These detectors together allow the complete physiochemical characterization of 1-100 nm size lipid particles and large 10E3 to 10E9 Da molecular weight apoliopoproteins carried by them. Such information is key in establishing correlation between the physiochemical characteristics of LDL and HDL particles and cardiovascular disease. Responsible sources that believe they possess the expertise and capabilities identified above are encouraged to submit to the Contracting Officer within 15 days from the posting of this notice, their written capabilities statement, in the format they choose, not to exceed 10 pages. Forward to Denise Rains, 315 East Montgomery Avenue, Spokane, WA 99207, fax (509)354-8099, or email dgr8@cdc.gov. All vendors must be registered in the Central Contractors Registry (CCR) prior to award of a federal contract. The website is www.ccr.gov. The Government will review any/all capabilities statements submitted and determine if other qualified sources do exist that could provide this requirement. Information received in response will be used solely for the purpose of determining whether to conduct a competitive procurement. If no affirmative responses are received within 15 days, in accordance with FAR 13.106-1(b)(1), negotiations will be held Postnova Analytics, Incorporated, a small business located in Salt Lake City, UT, as the only source and a purchase order will be issued without any additional notices being posted.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/CDCP/Spokane/00HCUGDH-2011-00633/listing.html)
- Place of Performance
- Address: CDC Distribution Center, Warehouse 3719 North Peachtree Road, Chamblee, Georgia, 30341, United States
- Zip Code: 30341
- Zip Code: 30341
- Record
- SN02540414-W 20110820/110819000048-78fe575c3929192b66ec145b33efe271 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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