SOLICITATION NOTICE
A -- Studies to Evaluate the Potential for Test Agents Selected by the National Toxicology Program to Induce Immunotoxicity
- Notice Date
- 2/10/2012
- Notice Type
- Presolicitation
- NAICS
- 541712
— Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, Office of Acquisitions, Office of Management, 530 Davis Drive, Durham, North Carolina, 27713, United States
- ZIP Code
- 27713
- Solicitation Number
- NIHES2011131
- Point of Contact
- WANDA M. HOLLIDAY, Phone: 919-541-0943
- E-Mail Address
-
hollida1@niehs.nih.gov
(hollida1@niehs.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This notice announces the intended release of solicitation number NIHES2011131. The National Institute of Environmental Health Sciences (NIEHS) is soliciting proposals to support and assist the efforts of the NTP to determine the effects of certain chemicals, drugs, or other environmental agents on the immune system of laboratory animals following exposure to xenobiotics. The Tasks that will be performed under this requirement involve the utilization of a comprehensive immune testing panel that evaluates the major components of the immune system for potential suppression or enhancement, as well as hypersensitivity and autoimmunity. The contractor shall: (1) screen for the potential of a test article to modulate the systemic immune response; (2) assess the performance of the hematopoietic system in generating specific stem cell populations; (3) evaluate resistance to disease and neoplasia using established models as part of more definitive studies; and (4) evaluate changes in immune cell numbers and hematological parameters. These endpoints will be evaluated in mice or rats. This requirement shall also involve the development, evaluation, and validation of novel assays to determine the potential of xenobiotics to induce alterations in immune parameters and the investigation of the mechanistic basis for chemical-induced perturbations of immune function. GLP regulations and Animal Welfare considerations will also apply to this requirement. This contract is expected to consist of a one year base period with nine one-year options, as well as optional quantities for additional immunotoxicological studies. It is anticipated that one cost reimbursement completion type award will be made with an anticipated award date of August 1, 2012. The proposed contract will be issued using full and open competition. The North American Industry Classification System (NAICS) code for this procurement is 541712 with a corresponding size standard of 500 employees. The Government intends to make an award using the procedures for competitive negotiated acquisitions as authorized in FAR Part 15. This is NOT a solicitation. The estimated issue date of the solicitation is March 16, 2012 and proposals will be due about 45 days after the solicitation release date. The solicitation will be posted on the Fed Biz Opps website. Interested firms who are unable to access the solicitation via the Fed Biz Opps website may request a copy of the solicitation from Wanda Holliday at: hollida1@niehs.nih.gov. Please reference the solicitation number RFP# NIHES2011131 on your written request. All questions regarding this acquisition shall be submitted in writing via email to: hollida1@niehs.nih.gov. Telephone inquiries will not be accepted.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIEHS/NIHES2011131/listing.html)
- Record
- SN02673153-W 20120212/120210233644-19c8782451a1b6218b057afdcf3ca57f (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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