SOURCES SOUGHT
A -- Receptor Profiling and Predictive Toxicology
- Notice Date
- 4/19/2012
- Notice Type
- Sources Sought
- NAICS
- 541711
— Research and Development in Biotechnology
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211 - MSC 9559, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SBSS-13-002
- Archive Date
- 5/19/2012
- Point of Contact
- Lisa V. Bielen, Phone: 301.443.6677
- E-Mail Address
-
lisa.bielen@nih.gov
(lisa.bielen@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a SMALL BUSINESS SOURCES SOUGHT NOTICE to determine the availability of small businesses (e.g., 8(a), veteran-owned small businesses, services-disabled veteran owned small businesses, HUB Zone small businesses, small disadvantaged businesses, and women-owned small businesses) having in-house capability to perform in vitro receptor binding assays on a wide variety of receptor targets, and perform follow-up binding and functional assays using appropriate in vitro biological systems. In addition, an interested organization should have the capacity to perform in vitro predictive toxicology assays. The objective is to provide NIDA preclinical discovery programs with a way to screen compounds using a battery of sites that may be alternative mechanisms of action of candidate compounds, or predictive of toxicology. This will facilitate the discovery of novel structural ligands for specified biological targets in the search for medications for the treatment of drug dependence disorders. Tasks to be performed: Task 1: Receptor Profile Screening (screening a compound at approximately 64 sites) Task 2: Receptor Binding Affinity and/or Functional Activity, (Computing IC50/Ki at sites showing activity in the profile screening or other sites of interest to NIDA); Task 3: Predictive Toxicology and Pharmacokinetic Testing (Cyp450, hERG channel, genotoxicity (Spot Ames or Greenscreen). Task 4: Assay Development (interested organizations may be asked from time to time to submit a proposal to develop an assay not in their current catalog). Interested organizations must submit a capability statement demonstrating extensive experience in the following areas: 1) expertise in evaluation and personnel with the knowledge of, and experience in conducting receptor and enzyme binding and/or functional assays as well as in vitro predictive toxicology including cardiovascular (e.g. hERG Channel) and genetic predictive assays (e.g. Spot Ames or Greenscreen); b) state-of-the-art assay methodologies; 2) equipment, instrumentation, facility, and personnel to perform the Tasks 3) DEA Research Registration for Schedules II to V with the potential to apply for Schedule I if required. THIS IS NOT A REQUEST FOR PROPOSALS: This notice is for information and planning purposes only and does not commit the Government to any contractual agreement. The Government does not intend to award a contract based on responses under this announcement nor otherwise pay for the preparation of any information sent for the Government's use. Any proprietary information should be so marked. All capability statements should provide the following: 1) company name and address; 2) point of contact, 3) phone/fax/email; 4) NAICS Code(s), 5) business size and status; 6) capability information in response to the requirement and qualifications identified in this notice; and 7) type(s) of business, if any (e.g.,: small, Veteran-owned, service-disabled Veteran-Owned, women-owned, 8(a), Small Disadvantaged Business (SDB), and Historically Underutilized Business Zone (HUBZone).
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-01/HHS-NIH-NIDA-SBSS-13-002/listing.html)
- Record
- SN02726254-W 20120421/120419235656-365e8581949f9cf40707b270645cf611 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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