MODIFICATION
Q -- Service - Measurements of Physical Properties of Protein Solutions
- Notice Date
- 1/11/2013
- Notice Type
- Modification/Amendment
- NAICS
- 541712
— Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Health Library, Bldg. 10, Room 1L25A, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- NIHLM2013654
- Archive Date
- 2/6/2013
- Point of Contact
- Sonya Owens-Cobblah, Phone: (301) 594-4666, Maxwell Kimpson, Phone: (301) 435-4380
- E-Mail Address
-
owenscobblahs@mail.nih.gov, kimpsonm@nlm.nih.gov
(owenscobblahs@mail.nih.gov, kimpsonm@nlm.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- National Institutes of Health (NIH), The National Library of Medicine (NLM) on behalf of the National Institute of Diabetes and Digestive Diseases (NIDDK) is conducting a market survey to determine the availability and technical capability of qualified small businesses, veteran-owned small businesses, service-disabled veteran-owned small businesses or HUBZone small businesses that can provide measurement of the concentration and shear dependence of the viscosity of highly concentrated solutions of individual proteins, individual polymers, mixtures of proteins and mixtures of proteins and polymers. The Contractor shall: 1. Prepare highly concentrated solutions of various proteins and mixtures of proteins under conditions of varying pH and ionic strength, as specified by NIDDK. 2. Perform measurements of the concentration dependence of the viscosity of these solutions. 3. Provide detailed documentation of all preparations and measurements, and complete data obtained from each measurement. 4. Contribute to analysis of the results as necessary to be performed: Solutions will be prepared and measurements performed on a continuous basis during the term of the contract. Reports of progress will be provided at least once weekly by the Contractor, and consultations between NIDDK and the Contractor will be held frequently via oral or written communication, so that results may be discussed and experimental goals and protocols revised if necessary in light of results obtained. Special equipment or procedures to be used: The Contractor will perform the requested measurements using a viscometer/rheometer specifically designed to carry out measurements of the type that we wish to perform. The amount of sample required to perform the requested measurements is less than one tenth of that required to perform equivalent measurements using commercially available instrumentation. In addition, the unique automated dilution system incorporated into this special viscometer enables a complete profile of viscosity as a function of concentration to be obtained about twenty times more rapidly than an equivalent set of experiments can be performed using a conventional viscometer. Both of these unique capabilities are essential to performance of the requested measurements within the time frame of the requested contract. Some of the proteins that NIDDK seeks to characterize are engineered monoclonal antibodies that are available only in quantities that are too small to characterize via conventional means. Results obtained from the instrument have been validated by comparison of results obtained for small quantities of several proteins and polymers using the custom viscometer with published results obtained using much larger quantities of the same proteins and polymers in commercially available viscometers. Specifications for measurement: 1. Total sample required for an entire concentration series: <1 ml of the highest concentration solution (up to 200 g/l) 2. Precision of concentration determination: better than 3% 3. Accuracy of viscosity measurement: better than 3% of measured value 4. Precision of viscosity measurement: better than 0.1% 5. Range of viscosity measurement: 1cP to 1000 cP 6. Range of applied shear: 10 s-1 - 104 s-1 7. Temperature control: better than ± 0.5oC 8. Viscosity of each solution must be measured at >25 concentrations obtained via serial dilutions 9. Optional inline measurement of concentration via absorbance 10. Entire series of viscosity measurements performed on a single sample at different concentrations must be completed within 3 hours to avoid sample degradation. 11. Measurements must be made by staff experienced in the preparation and safe handling of valuable biologically derived materials, including engineered monoclonal antibodies. Expected deliverables, if any: Data obtained from experiments, complete documentation of all procedures performed in conduct of the experiments. Period of Performance: February 1, 2013-July 31, 2013 This request is for interested firms with the capability of providing the items listed above and to submit a capability statement along with projected pricing, to assist the Government in determining in accordance with Federal Acquisition Regulation (FAR) 19.502-2(b) whether or not this procurement will be set-aside for any of the programs described above. The intended procurement will be classified under North American Industrial Classification (NAICS) code 541712 with a size standard of 500 employees. POTENTIAL SOURCES SHALL PROVIDE THE FOLLOWING INFORMATION IN THEIR RESPONSE: Company name, address, phone number, primary contact(s), e-mail address, NAICS code(s), business size (i.e., small/large) and DUNS number. All respondents are requested to identify their firm's size and type of business. Interested firms responding to this market survey must provide (a) capability statement demonstrating their experience, skills and capability to fulfill the Government's requirements for the above. The capability statement shall be in sufficient enough detail, but not to exceed 10 pages, so that the Government can determine the experience and capability of your firm to provide the requirements above. Your capability statement, not to exceed 10 pages, should include references. A copy of the capability statement must be received at the address identified in this synopsis by no later than close of business (2:00 pm local time at designated location) on January 22, 2013. Responses by fax or e-mail WILL BE ACCEPTED. This announcement is for information and planning purposes and is not to be construed as a commitment by the Government, nor will the Government pay for information solicited. The Government will neither award a contract solely on the basis of this synopsis nor will it reimburse the contractor for any costs associated with preparing or submitting a response to this notice. This synopsis does not constitute a Request for Quotation, Request for Proposal (RFP) or an Invitation for Bid (IFB), nor does this issuance restrict the Government's acquisition approach. DISCLAIMER AND IMPORTANT NOTES: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIHL/NIHLM2013654/listing.html)
- Place of Performance
- Address: National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN02963695-W 20130113/130111233918-16698f5ee9ae19d42223006bcf271ab6 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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