SPECIAL NOTICE
A -- Strategies for Screening Neurotoxicants
- Notice Date
- 3/28/2013
- Notice Type
- Special Notice
- NAICS
- 541380
— Testing Laboratories
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, Office of Acquisitions, Office of Management, 530 Davis Drive, Durham, North Carolina, 27713, United States
- ZIP Code
- 27713
- Solicitation Number
- NIEHS32813
- Archive Date
- 5/11/2013
- Point of Contact
- Patrick P Barbour, Phone: 919-541-7596
- E-Mail Address
-
barbourp@niehs.nih.gov
(barbourp@niehs.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Request for Information "Strategies for Screening Neurotoxicants" "This is a Request for Information (RFI). This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this RFI is to obtain knowledge and information for project planning purposes." a. Background For the purposes of this request, neurotoxicity means adverse outcomes to the nervous system resulting from exposure during any life stage. Special emphasis is placed on identifying assay systems that interrogate cellular and molecular events that are critical to the development and/or function of the nervous system. The NTP is also interested in receiving recommendations on molecular targets within critical cellular toxicity pathways in biochemical- or cell-based assays or alternative animal models that assess the potential ability of compounds to act as toxicants to the developing or adult nervous systems. b. Purpose and Objectives To facilitate the prioritization of compounds for in vivo neurotoxicity testing, the NTP seeks information on medium- or high-throughput technologies and assay systems that allow for the batch screening of compounds (e.g., 25-50) in biochemical- or cell-based, assays or alternative (non-rodent) animal models. For the purposes of this RFI, neurotoxicity means adverse outcomes resulting from exposure during any life stage. Special emphasis is placed on identifying assay systems that interrogate cellular and molecular events that are critical to the development and/or function of the nervous system. The NTP is also interested in receiving recommendations on molecular targets within critical cellular toxicity pathways in biochemical- or cell-based assays or alternative animal models that assess the potential ability of compounds to act as toxicants to the developing or adult nervous systems c. Information sought 1.Information on technologies/assays currently available for screening critical pathways involved in neurotoxicity where the endpoint is associated with a phenotypic manifestation of toxicity in vivo (adverse outcome) a.The preferred technologies/assays will have the ability to batch screen sets of at least 20 compounds to produce a concentration response curve suitable for defining the potency and efficacy of a response and will have been demonstrated to be both reliable and relevant. b.Assay specifics requested include information on the robustness of the assay and dose-response and time-course toxicity profiles, as well as to what extent the assay informs on specific neurotoxicity life stages windows (i.e., developmental, juvenile, ageing. 2.Information on assays that can be used to measure the activity of a compound on a molecular initiating event or key event within a neurotoxicity adverse outcome pathway. 3.Information on the best molecular or cellular targets that accurately characterize the activity of a compound within a specific pathway resulting in an adverse neurotoxic outcome. 4.Information on assays, technologies, or methods that will aid in identifying neurotoxic compounds, which are activated or deactivated by metabolic activity. 5.Opinions regarding the difficulty and/or feasibility of the potential requirement and/or proposed acquisition (such as contract type, pricing, etc.), possible solutions and approaches that may currently exist in the marketplace, and information regarding innovative ideas or concepts. 6.General information, which estimates the effort or time that may be required for an experienced organization to complete the work, identified above. Note: this information is for planning purposes only, DO NOT include detailed estimates. 7.Respondents are asked to provide the following: DUNS number, organization name, address, technical and administrative points of contact (including names, titles, addresses, telephone and fax numbers, and e-mail address), NAICS code, and size and type of business (e.g., 8(a), HUBZone, WOSB, SDVOSB, etc.). 8.Information packets should not exceed one (1) page in length, excluding standard brochures. Telephone and facsimile responses will not be accepted. Electronic or hard-copy (4 copies) information packages are acceptable. Electronic information shall be in Microsoft Word, Adobe PDF, Microsoft Power Point, or other Microsoft compatible format sufficient to clearly read the information provided (electronic submitters need only send one copy) to barbourp@niehs.nih.gov. 9.Please include a cover page, identify the technical and administrative points of contact for the organization, including names, titles, addresses, telephone and fax numbers, e-mail addresses, and organization name. 10.Information packages shall be submitted for receipt within (30) days from the date of the announcement, April 26, 2013 at 4:30 pm EST. d. Disclaimer and Important Notes This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed. Information provided will be used to assess tradeoffs and alternatives available for the potential requirement and may lead to the development of a solicitation. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. Any solicitation resulting from the analysis of information obtained will be announced to the public in Federal Business Opportunities in accordance with FAR Part 5. Responses to this notice will not be considered adequate responses to a solicitation. Confidentiality. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIEHS/NIEHS32813/listing.html)
- Place of Performance
- Address: N/A, United States
- Record
- SN03023050-W 20130330/130328234823-88740dfc891067527022f6249a4fe8f9 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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