Loren Data's SAM Daily™

FBO DAILY - FEDBIZOPPS ISSUE OF MAY 12, 2013 FBO #4187
SOURCES SOUGHT

99 -- DNA Tracking Software

Notice Date

5/10/2013
 

Notice Type

Sources Sought
 

NAICS

541511 — Custom Computer Programming Services
 

Contracting Office

Department of Justice, Federal Bureau of Investigation, Procurement Section, 935 Pennsylvania Avenue, N.W., Washington, District of Columbia, 20535, United States
 

ZIP Code

20535
 

Solicitation Number

05102013
 

Archive Date

6/1/2013
 

Point of Contact

Dawn Morgan, Phone: 304-625-4564, Michael Konchesky, Phone: 304-625-4031
 

E-Mail Address

Dawn.Morgan@ic.fbi.gov, michael.konchesky@ic.fbi.gov
(Dawn.Morgan@ic.fbi.gov, michael.konchesky@ic.fbi.gov)
 

Small Business Set-Aside

N/A
 

Description

This Request For Information (RFI) is being issued on behalf of the Federal Bureau of Investigation (FBI). THIS IS A REQUEST FOR INFORMATION ONLY. THIS IS NOT A REQUEST FOR PROPOSAL OR QUOTE. This request for information (RFI) is issued solely for information and planning purposes and does not constitute a solicitation or as an obligation on the part of the Government to acquire any products or services. No entitlement to payment of direct or indirect costs or charges by the Government will arise as a result of contractor submission of responses to this RFI or the Government's use of such information. Responses to this RFI will not be returned. It is the intent of the Contracting Officer to use this for market research purposes only. The Federal Bureau of Investigation (FBI) intends to negotiate a sole-source contract for on-site technical support, support and maintenance and software enhancements to STaCS DNA Inc., 2255 St. Laurent Blvd., Suite 206, Ottawa, ON, K1G 4K3. The FBI has a requirement for STaCS software enhancements/modifications as well as on-site technical support and software support and maintenance. The STaCS software is currently being used by the Laboratory Division to track the day to day processing of DNA casework and database samples. Please submit a written statement indicating your interest and include how the software being proposed can seamlessly interface with the FBI's current DNA evidence and database sample processes. The FBI deems this requirement for STaCS software enhancements/modifications, on-site technical support and software support and maintenance a sole source due to the fact that the STaCS software integrates seamlessly with the FBI's current analytical processing of DNA casework and database samples. The STaCS software provides the following: Software Functionality for FDDU Applications • Capture metadata data based on "CRUD" (Create, Report, Update, Delete) to capture who is accessing/viewing the data, when, why, etc. • Monitors all aspects of the DNA analysis process (e.g. person who performed each procedure, date/time, reagents/instruments used, results, etc.). • Utilize barcoding for electronic data capture to track the receipt, receipt, inventory and analysis of DNA database samples received by the FDDU. • All reagents and instruments are barcoded within the software, which facilitates the tracking of the Quality Control (QC) procedures and overall status of each reagent or instrument. • Provide an interface for the robotic systems, high throughput instrumentation and expert system data analysis software utilized to streamline the DNA analysis process in FDDU. • Operate as a command and control system between the various robotics and analysis instrumentation - launching and monitoring processes, collecting data, and tracking samples. • Security configuration module to allow administrator to manage access to modules by defining and implementing users, roles and security groups. • Provides numerous reporting options to include detailed reports about submission data and the DNA analysis of each submission. Provides numerous statistics reports to track the laboratory workload and report on the average turnaround time for each sample uploaded to CODIS. • Software must be able to be granted disposition authority by the FBI Records Management Division (RMD) for records created and maintined by the FBI Laboratory's DNA profile databases. Quality Assurance & Quality Control (QA) • Validate each reagent/consumable and instrument prior to use and prevents the use of expired reagents or instrument that are not online. • Maintain an audit trail of reagents and lot numbers used at every step of the analytical process. • Consumable Configuration (Add, delete and manage information about reagents/supplies) • Receiving (Receive and record pertinent information and assign barcodes to each reagent/supply.) • Module to document and report Chemical Preparation, Chemical Releasing, Consumable Rejection, Chemical Dispensing, Container Breakdown, Chemical QA/QC modules • Inventory of all reagents/supplies with lot details and storage subsystem. • Defined Profile for controls • Training & Proficiency Test Module • Maintenance Schedule (Schedules, notifications, removal from service) Instrument Interfaces & Configuration • Ability to perform Y-STR and STR DNA analysis using commercially available amplification kits • Provides an interface with commercially available robotic workstations and instrumentation as well as expert system software and third party RFID software. • Configure the layout of multiple types of 96-well plates • Configure scenarios for each step of the DNA analytical process. Accessioning • Barcodes used for electronic data capture to track the receipt and inventory of collection kits used to collect DNA database samples. • Complete audit history available for all submission data. • Submission forms scanned and processed using TurboScan NG Optical Character Recognition (OCR) software. • Validate the imported data to identify missing or incomplete information. • Search personally identifying information for each new submission against all existing submissions to identify potential duplicate samples so they can be removed from processing stream. • Interface with Laserfiche and package submission data with scanned index fingerprints to generate a CAR File (Criminal Ten-print Record - NIST XML file) to be sent to CJIS for identity verification of the offender. • Import of identity verification reports generated by CJIS and reconcile data with personally identifying information submitted with the DNA sample. Administrative Provide administrative modules to generate notifications and address the following: Potential Rejects, Missing Information, Potential Duplicates, Sample Expungements, Be on the Look out (BOLO), Information/Item Requests. Laboratory Processing • The following analytical steps are required in the software: Plate Creation, Plate Preparation, Sample Punch, Extraction, Amplification Set-up, Amplification, Electrophoresis Plate Preparation, Denature, Capillary Electrophoresis, Data Analysis. • Automatically generate a worklist of samples and/or plates that require each step of the DNA analytical process. • Provide the flexibility to perform a manual or automated procedure for each analytical step and to process one or multiple plates at the same time. • At the end of each analytical step, the resulting log and/or output files generated by the robotic systems or instrumentation are imported and stored in the database. Data Analysis and CODIS • Interfaces with the AB GeneMapper ID-X expert system software to faciliate the interpreation and technical review of DNA profiles generated at the end of the DNA analysis process. • Verify DNA results (controls and NDIS acceptable values) during the import of the DNA and identify samples for rework. • All acceptable samples are available for addition to a CMF (Common Message File) file (DAT or XML) for import in CODIS. Technical Support • Maintenance agreement to include all available software upgrades and unlimited customer support. • Support and maintenance to include a Help Desk which provides Tier 1 through Tier 4 support for addressing technical issues with the application and database. • On-site contractors provide Tier 2 desktop support through Tier 4 Subject Matter Experts (SMEs) for support and maintenance of the servers and clients as well as the BAS LAN. Software Functionality for nDNAU & mtDNAU Applications Security • Data security through role based and access based configuration for access rights to all modules and reports • User management integrated with Microsoft Active Directory to provide Single Sign-On functionality (SSO) • Digital signing of user generated reports for non-repudiation • Provide per user profile configuration (short cuts, file locations, customizable menus, etc.) Evidence Management • Storage functions to store, retrieve, discard, transfer (person to person, person to/from storage, and person to/from external source), and locate evidence • Record item metadata (barcode, description, classification, photos, etc.) • Create sub-items of evidence linked to primary item • Create archive item of evidence linked to primary item • Customizable evidence storage • Barcode based chain of custody evidence tracking to include derived and secondary evidence • Secondary evidence and batch tracking from process to process Storage Configuration • Define storage types (cabinet, refrigerator, etc.) • Define storage condition (temperature, explosive, corrosive, and secure storage) • Define storage contents (evidence, secondary evidence, processing batches, consumables) allowed • Access controlled by user and/or user role • Define maintenance schedules e.g. yearly calibration of -80⁰C freezer • Define hierarchical storage relationships e.g. shelve location in a cabinet in a specific room • Provide utilities to inventory storage, locate contents, and transfer contents Laboratory Process Configuration • Define and document user-managed exams serological exams for examining forensic evidence • Define user-managed processes for Nuclear DNA profile generation o Batch setup sample layout for 96- or 384-well plate, tube racks, etc. o DNA Isolation Setup (Differential and Non-differential) with extract volume tracking o Quantitation Setup & Quantitation o Post isolation normalization of DNA concentration o Amplification Setup & Amplification o Capillary Electrophoresis Setup & Analysis o Data Analysis with contamination detection • Define and associate SOPs with serological exams and DNA processing • Assign sample batches to a user for processing and tracking processing time per user, per case, and by case type. • Define rework points for each batch process and individual samples • Define workflows for evidence examination type to route samples through specific laboratory processes • Define commercially available scientific instruments for sample tracking • Track sample pipettes used during each process Instrument Configuration • Configure each instrument (location, serial number, barcode ID, software directories, and instrument specific settings e.g. injection voltage on a CE) • Interface for liquid handling robots (Tecan, Hamilton, Qiagen, Agilent) and analysis instruments (Life Technologies, Agilent, KingFisher) to export run-time settings, sample maps, and import data • Define instrument QA and calendar-based maintenance schedules and prevent out-of-specification instruments from being used in analysis • Define QA process required and associated SOPs • Record date, outcome and the user who performed QA steps SOPs • Define and associate SOPs with all workflow steps e.g. evidence handling, reagent prep, exams, analysis, and reporting • SOPs electronically viewable from each processing step Workload Management • Assign and track users for each processing step • Track user workload for exams assigned, cases assigned, and pending processes • Track user and batch processing efficiency through reports and "To Do" work list Consumables Management and Inventory Control • Define recipe for prepared reagents • Define kits • Define QA/QC requirements o Instructions and external reference materials (SOPs and notes) o Required reference reagents o Required instrument type and model Track Controls • Define process and contamination control type (blanks, negative and positive) • Define control DNA profile for different kits • Validate control profiles for processing steps e.g. amplification positive control yields expected result Case Administration • Request date and evidence submissions received • Capture case metadata and store date electronically • Separately track processing status for each item of evidence and derived samples in addition to overall case status. • Define alerts for expected cases (BOLOS) • Track audit history for every edit to include date-time, user making the edit, data before/after change Sample Management • Define new samples collected from items of evidence • Record if the sample is consumed with a comment • Record each processing step the sample has been through including sample fractions generated and the relationship to each sample DNA Profile Management • Import Nuclear STR and Mitochondrial DNA sequence profiles • Compare imported sample profiles against defined control profiles for contamination • Compare imported sample profiles against sample profiles on batch for cross-contamination • Provide management of NDIS acceptable values • Track raw and edited profile along with sample source • Allow export of profile to CODIS, PopStats, EMPOP and Y Stats for upload and analysis • Export a call sheet for inclusion in the case file • Manages profiles in relation to case and evidence data CODIS • Provide CODIS match tracking and generate match request letter • Track and print Missing Persons Pedigree Trees • Generate bulk NDIS profile upload file Communication and Reporting • Provide communication log for internal and external communications • Associate log entries at multiple levels including case, evidence item, samples, and processes • Provide data exchange interface with external LIMS • Generate reports (Unit metrics, Discovery, Instrument Maintenance, Management, etc.) • Provide the ability to define custom reports using configurable templates • Provide Real-time Metrics via a dashboard utility Mitochondrial DNA (mtDNA) Specific Processing Requirements • Individual and Batch setup sample layout for single tube through 96-well plate format, tube racks, etc. • DNA isolation Set-up (Organic and Inorganic) for manual and automated processing with exact volume tracking. Flexibility to utilize varying sample specific procedures, consumables, etc. • Quantitation Setup & Quantitation utilizing non-commercial mtDNA assay with laboratory specific performance parameters. • Post isolation normalization of DNA concentration based on genome concentration. • Use quantitative values to determine appropriate mtDNA amplification strategy to maximize DNA sequence obtained using non-commercial amplification kits/primers (Whole Control Region, Hypervariable Regions, MiniPrimers). • Design mtDNA module for post-amplification sample clean-up using enzymatic chemistry. • Design mtDNA module for post-amplification Quantitation of samples and corresponding controls using microcapillary array instrumentation (Agilent). Evaluate ratio of sample concentration to observed contaminant concentration in negative controls for each amplified region to determine processing/reprocessing scheme. • Post isolation normalization of mtDNA concentration for Sanger cycle-sequencing. • Design mtDNA module for post Sanger cycle-sequencing clean-up, • Design mtDNA sequencing module using capillary electrophoresis for sample and corresponding controls created for forward and reverse strand sequencing. • Design module for sequence evaluation using validated COTS Sequencher software. Software must store composite DNA sequence, identifying observed polymorphisms and heteroplasmy, utilize stand sequence references, and IUPAC sequence coding. • Design mtDNA sequence profile management module which auto-populates derived final mtDNA sequence determined by two independent evaluations. Please also include the following information the statement: 1) Company name, address, telephone number, a point of contact with e-mail address, Federal Cage Code, Data Universal Numbering System (DUNS), business size, and security clearance level. 2) Company shall be registered with the System for Award Management (SAM) at www.SAM.Gov, a Federal Government owned and operated free website that consolidates Central Contractor Registration (CCR) and Excluded Parties List System (EPLS). 3) Confirmation of a Defense Contract Audit Agency approved accounting system. Electronic files should be in MicroSoft Office (Word, Excel, PowerPoint) or PDF format. All information should be UNCLASSIFIED material only. Information should not exceed 5 one-sided 8 ½ x 11 pages, with one inch margins, and font no smaller than 12 point. E-mail verification will be sent upon receipt. All submissions should be e-mailed no later than 3:00 pm Eastern Standard Time, May 17, 2013, to CO Dawn Morgan at dawn.morgan@ic.fbi.gov, or CO Michael Konchesky at Michael.konchesky@ic.fbi.gov.
 

Web Link

FBO.gov Permalink
(https://www.fbo.gov/spg/DOJ/FBI/PPMS1/05102013/listing.html)
 

Place of Performance

Address: 2501 Investigation Way, Quantico, Virginia, 22135, United States

Zip Code: 22135
 

Record

SN03059763-W 20130512/130510235552-342cfd2ec145cb5c68a20f535c9d954c (fbodaily.com)
 

Source

FedBizOpps Link to This Notice
(may not be valid after Archive Date)

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