SOURCES SOUGHT
B -- Metobolite Profiling for the Development
- Notice Date
- 7/1/2013
- Notice Type
- Sources Sought
- NAICS
- 541690
— Other Scientific and Technical Consulting Services
- Contracting Office
- Department of Health and Human Services, Centers for Disease Control and Prevention, Procurement and Grants Office (Atlanta), 2920 Brandywine Road, Room 3000, Atlanta, Georgia, 30341-4146
- ZIP Code
- 30341-4146
- Solicitation Number
- 2013-59438
- Archive Date
- 7/18/2013
- Point of Contact
- Tayaria L Smith, Phone: 7704882797
- E-Mail Address
-
gqq4@cdc.gov
(gqq4@cdc.gov)
- Small Business Set-Aside
- N/A
- Description
- Notice of Intent 2013-59438 The Centers of Disease Control and Prevention intends to award a sole source, firm fixed price contract, in accordance with FAR Part 13, using simplified acquisition procedures, to the University of Texas, Austin Texas 78712. The University of Texas will deliver the following: Performance Work Statement Receptor Development and Platform Optimization for the Development of Diagnostic Biosensor for Malaria The Malaria Branch at the US Centers for Disease Control and Prevention (CDC/MB) conducts surveillance, investigations, and studies of malaria to develop effective methods for the prevention, control, and elimination of disease worldwide. To that end, programs of epidemiologic and laboratory research investigating the biology, ecology, and host relationships of the malaria parasite have been established. In rural malarious areas, the currently available malaria diagnostic tools based on morphology, parasite antigen recognition, or DNA analysis of blood samples are limited to large-scale laboratories capable of expert microscopy or real-time molecular screening of asymptomatic and low density malaria. A primary aim of this collaborative project is to first determine the malaria parasite specific low-molecular-weight metabolites found in the urine and saliva of malaria infected humans. CDC provides substantial technical support to various malaria control programs globally and is a key partner in the President's Malaria Initiative (PMI), a vital component of the CDC priority to improve global health. Previous success in malaria controls has led to increased discussion about the medium- term feasibility of malaria elimination in selected areas, and in the long-term, malaria eradication. One of the critical elements in malaria elimination/eradication is large-scale and real-time screening of asymptomatic and low density malaria infection at the community level. Achieving prompt treatment will decrease the parasite reservoir and further reduce malaria transmission. I. Project Description The targets of the non-invasive sampling are malaria parasite-specific low-molecular-weight metabolites. Based on biochemical principles, the concentration of naturally-eliminated parasite metabolic small molecule wastes (end products) should be higher in urine or in saliva than in blood, making them ideal biomarkers for non-invasive detection of malaria infection. Achieving malaria parasite detection using this low cost and portable method has several advantages including: 1) increased sensitivity, 2) non-invasive sample collection, 3) ease of use in rural settings, and 4) eliminating the need for cold-chain logistics. The study is divided into two parts with specific objectives. II. Period of Performance The period of performance shall be 12 months from the date of award. III. Deliverable By the end of the study, the Laboratory of Biochemistry and Materials Chemistry, will provide: 1) the results of affinities and specificities of the aptamers or antibodies against 3-Methylindole, and 2) the evidence that demonstrates the use of most inexpensive and simple aptamer- or antibody-based oPAD2 with different readout devices for detection of 3-Methylindole and their sensitivity and LOD. IV. Minimum Vendor Qualifications Qualifications of research team: Research team should have extensive experience designing and fabricating paper fluidic devices that integrate electrochemical detection for biochemical detection. The team must also be a leader in the design and synthesis of specific chemical probes for biological targets. The University of Texas appears to be the only organization that can provide this service. Their research team has extensive experience designing and fabricating paper fluidic devices that integrate electrochemical detection for biochemical detection. The team also is a leader in the design and synthesis of specific chemical probes for biological targets. This advertisement ends in 3 days accordance with FAR 5.203 (A) (1). No Request for Quotes (RFQ) will be issued based upon this Notice of Intent. Any interested companies are welcome to submit their credentials and ability to provide the services, via e-mail, gqq4@cdc.gov. Include reference number (2013-59438). Send responses by Wednesday July 3, 2013.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/CDCP/PGOA/2013-59438/listing.html)
- Record
- SN03104393-W 20130703/130701234714-8a456887963edc8d67592c7eeab11aac (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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