SOURCES SOUGHT
66 -- In vivo imaging system for brain reward circuit dysfunction in drug addiction
- Notice Date
- 7/23/2013
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- HHS-SSSA-NIDA-SS-13-3044514
- Archive Date
- 8/14/2013
- Point of Contact
- Hunter A. Tjugum, Phone: 301 435 8780
- E-Mail Address
-
hunter.tjugum@nih.gov
(hunter.tjugum@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. Based on the responses received from this Sources Sought notice, the proposed acquisition may be solicited as a Total Small Business Set-Aside. All eligible small business concerns responding to this announcement must have the capabilities to provide the below product within 120 days after receipt of order. Delivery will be made to the Clinical Center located on the NIH main campus in Bethesda, MD. The proposed requirement is for a laser two-photon imaging system with a vibration isolation table to house the laser and the two-photon imaging system. This system will be used to elucidate dysfunction of reward circuits during the development of long-term drug addiction. This system will be required for optical imaging techniques to examine neuronal dysfunction in drug addiction. The Confocal Core Facility needs a two-photon imaging system that will be used to examine neuronal circuit dysfunction through the development of long-term drug addiction and relapse. System will use the rodent behavior paradigm of drug addiction and in vivo imaging techniques. The overall goal of the proposed project is to elucidate the neuronal mechanisms in the prefrontal cortex (PFC) that underlie drug addiction. The Confocal Core Facility will accomplish the goal by using a combination of a mouse behavior paradigm of cocaine self-administration, extinction, and reinstatement procedures, and longitudinal in vivo two-photon microscopy. This project is conceptually novel and technically innovative. Conceptually, the focus on neuronal mechanisms in the PFC for addiction is novel. While diminished cognitive control of compulsive drug-seeking and -taking behavior is a known hallmark of addiction, little is known about the specific neuronal changes in the PFC-the cognitive center of the brain-that underlie addiction and relapse. Technically, the subject project is innovative in the use of in vivo two-photon microscopy to examine structural plasticity of excitatory neurons in the brains of live mice longitudinally, and the use of repetitive in vivo calcium imaging in awake mice to examine activity changes in neuronal circuits longitudinally. Importantly, the Confocal Core Facility microscopy approach will enable detecting subtle changes in neuronal morphology and activity that potentially underlie addiction in the same neurons of the same mice as mice develop addiction and relapse, which are unlikely to be detected using other techniques comparing different animals at different stages of addiction. Interested parties should submit a tailored capability statement, which clearly defines the ability to provide this equipment and that specifically addresses the equipment's functionality and specifications required to perform the brain imaging. Responses should be limited to 15 pages in length, including attachments, and sent as an Adobe PDF or Microsoft Office file to: tjugumha@mail.nih.gov prior to the closing date contained in this announcement. Responses must include the respondents' DUNS, organization name and address, point of contact, and size and type of business pursuant to the North American Industry Classification System (NAICS) code identified in this notice. Disclaimer and Important News: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/HHS-SSSA-NIDA-SS-13-3044514/listing.html)
- Record
- SN03124997-W 20130725/130723235835-7f8afc002cae6b24eb31c89e802a0c3a (fbodaily.com)
- Source
-
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