SOLICITATION NOTICE
R -- Image Formation and Reconstruction Techniques to Improve Spatial and Temporal Resolution in Electron Paramagnetic Resonance Imaging
- Notice Date
- 8/2/2013
- Notice Type
- Presolicitation
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E128, Rockville, Maryland, 20852, United States
- ZIP Code
- 20852
- Solicitation Number
- NCI-130109-HN
- Archive Date
- 8/17/2013
- Point of Contact
- Huy Nguyen, Phone: 2402765570, Seena Ninan, Phone: 240-276-5419
- E-Mail Address
-
anh-huy.nguyen@nih.gov, ninans@mail.nih.gov
(anh-huy.nguyen@nih.gov, ninans@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Contracting Office Address: Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive Room 1E154 Bethesda, MD 20892 Description: The National Cancer Institute (NCI), Center for Cancer Research (CCR), Biophysical Spectroscopy Section of the Radiation Biology Branch (RBB) plans to procure on a sole source basis custom image data acquisition and reconstruction algorithms for Electron Paramagnetic Resonance Imaging (EPRI) from GenEpria Consulting, Inc., 6011 University Blvd, Suite 120, Ellicott City, MD 21048. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1). The North American Industry Classification System code is 541990 and the business size standard is $14.0 million. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. Period of Performance shall be from award through twelve (12) months with two (2) twelve (12) month option periods. It has been determined there are no opportunities to acquire green products or services for this procurement. The Biophysical Spectroscopy Section of the Radiation Biology Branch (RBB), CCR, NCI has been developing in vivo Time-domain EPR imaging methods using narrow-line non-toxic spin probes based on the trityls (triarylmethyl radical). These are one of a kind methods being exclusively developed by NCI for small animal imaging to generate three dimensional oxygen maps to understand and monitor radiological and chemotherapeutic treatment of tumor models. Currently a new and improved pulsed oximetric EPR imaging strategy based on Single Point (SPI) and Spin-Echo (SE) strategy that delivers high resolution spin and quantitative oximetric images. The contractor shall provide the following: 1. Pulse sequence modification for Selective excitation & imaging of preferred metabolites: Hyperpolarization involving electron-Nuclear Overhauser enhancement at liquid He temperatures can enhance the polarization and sensitivity of selectively labeled 13C compounds by more than 4 orders of magnitude. However, the polarization is short lived and imaging experiments are to be performed with special sequences such as Echo Planar Imaging (EPI).This opens up unique ways of monitoring and following trace metabolites and understanding biochemical pathways involved in tumor physiology. Alternatively one can perform in vivo distribution specific metabolites with increased sensitivity and by selectively exciting specific 13C NMR peaks (example specifically 13C-labeled pyruvate or lactate) by using specially designed pulse sequences and use simple gradient-echo methodology. This requires help in modifying the gradient echo imaging sequences to incorporate selective excitation pulses that excite only preferred metabolite(s) and generates images exclusively from them. 2. Algorithms that shall combine metabolic profile with EPR oximetry from normal and tumor-bearing tissues of mouse tumor models to provide semi-quantitative analysis of metabolic profiles and spin and oximetric images from EPRI and MRI. 3. Integration of EPR Oximetry, partial K methods and Spin-echo based SPI. 4. Real-time image visualization and co-registration involving partial k-space data in the Spin Echo based SPI mode along with MRI co-registration and analysis of resolution of oximetric images from EPRI and MRI images of very different intrinsic resolutions. 5. Algorithms for dynamic profiling of EPRI spin and oximetric images with improved temporal resolution. 6. Metabolomic and gene microarray data analysis and statistical support. 7. The contractor shall orient approved RBB users on the general architecture of algorithms developed based on the input provided by the users in an interactive fashion. 8. The contractor shall provide graphics user interfaces to simplify the software applications. 9. The contractor shall provide trouble shooting guidance by phone, email, help in the analysis and to support statistical evaluation of the results. GenEpria Consulting is the only known source for obtaining algorithms for image data acquisition and Image reconstruction of EPRI data. Since EPRI is practiced in very few laboratories, this expertise is not available commercially. GenEpria understands the computational intricacies of image formation and reconstruction used in EPRI and is the only known source for obtaining algorithms for image data acquisition and reconstruction algorithms for EPRI. GenEpria has been providing these services since 2009 and the algorithms being proposed for development must be compatible with the previously implemented software to make a seamless integration with the imaging studies. This is not a solicitation for competitive quotations. However, if any interested party, particularly small businesses, believe they can meet the above requirement, they may submit a statement of capabilities via fax or email. All information furnished must be in writing and must contain sufficient detail to allow the NCI to determine if it can meet the above unique specifications described herein. The capability statement must be received in the NCI contracting office on or before 4:00 PM EST on August 16, 2013. All questions must be in writing and can be faxed (240)-276-5399 or emailed to Anh-Huy Nguyen, Contract Specialist at anh-huy.nguyen@nih.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must have valid registration and certification in the System for Award Management (SAM) www.sam.gov. No collect calls will be accepted. Please reference solicitation number NCI-130109-HN on all correspondences.
- Web Link
-
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- Record
- SN03136546-W 20130804/130802234923-44cf42ac81edb98f795efb697804d81e (fbodaily.com)
- Source
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