SOURCES SOUGHT
B -- Metabolomic profiles and pancreatic cancer
- Notice Date
- 8/14/2013
- Notice Type
- Sources Sought
- NAICS
- 541380
— Testing Laboratories
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Bldg 1050, Frederick, Maryland, 21702, United States
- ZIP Code
- 21702
- Solicitation Number
- SS-130117-TK
- Archive Date
- 9/3/2013
- Point of Contact
- Tiffany D. Kittrell, Phone: 2402765434
- E-Mail Address
-
Tiffany.kittrell@nih.gov
(Tiffany.kittrell@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- SOURCES SOUGHT NOTICE: Metabolomic profiles and pancreatic cancer <img src="file:///C:\DOCUME~1\KITTRE~1.NIH\LOCALS~1\Temp\msohtmlclip1\01\clip_image001.gif" alt="" width="677" height="7" /> Notice Number: SS-NCI-130117-TK Issued By: National Cancer Institute (NCI), Office of Acquisitions (OA) http://www.nci.nih.gov or http://rcb.cancer.gov/rcb-internet/ Key Dates: Capability Statement Due Date: August 19, 2013 by 4:00PM EST This Small Business Sources Sought Notice (SBSS) is for information and planning purposes only and shall not be construed as a solicitation or as an obligation on the part of the National Cancer Institute (NCI). The purpose of this Sources Sought Notice is to identify qualified small business concerns including 8(a), HUB Zone or Service-Disabled Veteran-owned business concerns that are interested in and capable of performing the work described herein. The NCI does not intend to award a contract on the basis of responses received nor otherwise pay for the preparation of any information submitted. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This requirement is assigned North American Industry Classification System (NAICS) code 541380 with a size standard of $14 million is being considered. As a result of this Sources Sought Notice, the NCI may issue a Request for Quotation (RFQ) through FedBizOpps. THERE IS NO SOLICITATION AVAILABLE AT THIS TIME. However, should such a requirement materialize, no basis for claims against NCI shall arise as a result of a response to this Sources Sought Notice or the NCI’s use of such information as either part of our evaluation process or in developing specifications for any subsequent requirement. Metabolomics is a field of research devoted to the study of large numbers (400-800) of small molecules within biofluids, such as blood. Metabolomic profiles incorporate exposure from diet, lifestyle, the environment and genetics, among many other factors, that may be related to cancer risk. The Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), of the National Cancer Institute (NCI) is conducting a metabolome-wide association study (MWAS) using serum samples collected prospectively in a nested case-control study of pancreatic cancer. The aim of the study is to identify metabolites associated with pancreatic cancer risk. The purpose of this procurement is to use metabolomics to identify biomarkers related to pancreatic cancer. The NCI will send 266 serum samples from pancreatic cancer case and control participants and quality control samples from the ATBC Study cohort. Samples are to be run using the Orbitrap Mass-Spectrometry (MS) platform, with linkage of raw MS output to named and unnamed biochemicals. Contractor Requirements: 1. Store samples immediately in -80 degrees until ready for assays. 2. Measure metabolites using orbitrap MS on 266 ATBC samples. The samples will be sent boxed in batches of 32. All batches and samples within the batches should be assayed in the order provided by NCI. All samples will be sent at the same time. All analytical work performed by the contractor will be conducted under conditions of careful quality control and will follow the usual quality control procedures. All contractor internal quality control charts will be provided to NCI after the first batch and at completion of the work. NCI will review the data for the blinded quality control samples to assure that satisfactory reproducibility is being provided. 3. Link orbitrapMS output to named and unnamed biochemicals from a reference database. 4. Communicate to Contracting Officer’s Representative (COR) immediately via email or phone call if any problems. The contractor shall notify the COR immediately via e-mail or phone call if any unusual problems develop over the course of the project and/or explanations for repeating analyses, such as failure of analytical and quality control procedures, breakdown of freezers, instrumentation and equipment, and major changes in personnel that would produce delays or that would adversely influence the quality of the laboratory performance. 5. Deliver data to the NCI COR as tables of named and unnamed biochemicals and relative concentrations. This will be delivered by e-mail as either an Excel file or text file. 6. After the assays are run on each batch, residual samples will be stored in the laboratory at -80 degrees Centigrade. All biological materials provided by the U.S. Government, all residual specimens, and all data generated shall be the property of the U.S. Government and shall be returned to the U.S. government repository after the assays are completed and data approved by COTR. Period of Performance: · 12 Months from award How to Submit a Response: 1. Page Limitations: Interested qualified small business organizations should submit a tailored capability statement for this requirement not to exceed 10 single sided pages including all attachments, resumes, charts, etc. (single spaced, 12 point font minimum) that clearly details the ability to perform the requirements of the notice described above. All proprietary information should be marked as such. Responses should include a minimum of a two pages demonstrating experience over the past two years meeting the requirements of this notice. Statements should also include an indication of current certified small business status; this indication should be clearly marked on the first page of your capability statement (preferable placed under the eligible small business concern’s name and address). Responses will be reviewed only by NIH personnel and will be held in a confidential manner. 2. Due Date: <img src="file:///C:\DOCUME~1\KITTRE~1.NIH\LOCALS~1\Temp\msohtmlclip1\01\clip_image002.gif" alt="" width="2" height="44" /> Capability statements are due no later than 4:00 a.m. EST on August 19, 2013. Delivery Point: All information furnished must be in writing and must contain sufficient detail to allow the NCI to determine if it can meet the unique specifications described herein. Written responses can be emailed to Tiffany Kittrell, Contract Specialist at Tiffany.kittrell@nih.gov or mailed to the address located under Point of Contact. All questions must be in writing and can be faxed to (240) 276-5401 or emailed. A determination by the Government not to compete this requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must have valid registration and certification in the System for Award Management (SAM) www.sam.gov and the Online Representations and Certifications Applications (ORCA), http://orca.bpn.gov. No collect calls will be accepted. Please reference number SS-NCI-130117-TK on all correspondence. Disclaimer and Important Notes : This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, an RFQ may be published on FedBizOpps. However, responses to this notice will not be considered adequate responses to a solicitation(s). Point of Contact: Inquiries concerning this Notice may be direct to: Tiffany Kittrell 9609 Medical Center Dr, Room 1E141 Bethesda, MD 20892-9705 Tiffany.kittrell@nih.gov
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