MODIFICATION
R -- Obtain data describing the genotypes for new cases of Gastric Cancer from the High Risk Esophageal/gastric cancer region of Henan, China
- Notice Date
- 8/30/2013
- Notice Type
- Modification/Amendment
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E128, Rockville, Maryland, 20852, United States
- ZIP Code
- 20852
- Solicitation Number
- NCI-130148-TG
- Archive Date
- 9/27/2013
- Point of Contact
- Terry Galloway, Phone: 240-276-5384, Seena Ninan, Phone: 240-276-5419
- E-Mail Address
-
gallowaytl@mail.nih.gov, ninans@mail.nih.gov
(gallowaytl@mail.nih.gov, ninans@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- **** This Amendment is to clarify the first paragraph under "Description"***** Contracting Office Address Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E136, Bethesda, MD 20892, UNITED STATES Description National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), Genetic Epidemiology Branch (GEB), plans to procure on a sole source basis services to obtain data describing the genotypes for 29 single nucleotide polymorphisms (SNPs) from 3000 new cases of GC and 3000 new controls from the high-risk esophageal/gastric cancer region in Henan, China with First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou, Henan Province, 450052 PR China. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1) and is exempt from the requirements of FAR Part 6. The North American Industry Classification System code is 541990 and the business size standard is $14.0 million. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. The period of performance is twelve (12) months from date of award. It has been determined there are no opportunities to acquire green products or services for this procurement. Gastric cancer is the fourth most common cancer in the world and the second most common cause of cancer death. As a result of high rates and a large population, over 40% of all the world's esophageal cancer deaths occur in China. While environmental exposures are responsible for much of gastric cancer, evidence suggests that genetic factors also play an important role in the etiology of this malignancy, and identification of gastric cancer susceptibility genes may allow screening of populations to identify persons at particularly high risk who could then be targeted for prevention strategies (eg, chemoprevention or early detection). Scientists at the NCI published results from genome-wide association studies (GWAS) of two upper gastrointestinal (UGI) cancers - esophageal and gastric cancers - in 2010. One gene (PLCE1) was significantly associated with both esophageal and gastric cancers in this GWAS, but single nucleotide polymorphisms (SNPs) in many other genes also showed strong associations with risk of gastric cancer and merit further follow-up/replication. The NCI and the Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China (hereafter referred to as Zhengzhou University), initiated a collaboration in 2013 to identify susceptibility genes for developing gastric cancer (GC). The NCI UGI GWAS provided many clues to other genes of interest. The Zhengzhou University has collected a large number of GC cases with DNA that are available for genotyping in replication studies. Importantly, the patients (GC cases and controls) collected by Zhengzhou University come from north central China near the Taihang Mountain region which has very high GC rates, particularly cancer in the upper part of the stomach adjacent to the esophagus and known as the gastric cardia. The rates of gastric cardia cancer in the Taihang Mountain region are the highest in the world and this geographic area represents the optimum place to study genetic susceptibility to GC, particularly gastric cardia cancer. This study involves follow-up testing of the top single nucleotide polymorphisms (SNPs) identified in NCI's previous analysis of GC GWAS data. This follow-up must be conducted in a new set of independent samples of cancer cases and controls to confirm/replicate the findings from the initial GC GWAS. NCI/DCEG requires the contractor to provide genotype information of the genotypes for 29 SNPs from 3000 new GC cases and 3000 new controls to include information on subject age, sex, alcohol use, and smoking use. Zhengzhou is the provincial capital of Henan Province which is located in the heart of the region of high risk for both esophageal squamous cell carcinoma (ESCC) and GC, particularly gastric cardia cancer in China. It is the geographic region with the highest risk for gastric cardia cancer anywhere in the world. Scientists at Zhengzhou University have been conducting studies of GC in this high-risk region for over 30 years and have already accumulated a large number of GC cases with germline DNA available for genetic study. They are the only institution in China that has available DNA the large number of GC cases (n=3000) from this high-risk region of China required to perform a valid replication study of the GC GWAS finding (which are also from this high-risk region of China). This notice is not a request for competitive quotation. However, if any interested party especially small businesses, believes it can meet the above requirement, it may submit a capability statement, proposal, or quotation, which shall be considered by the agency. The responses and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 11:00 AM EST, on September 12, 2013. All responses and questions must be in writing and faxed 240-276-5401 or emailed to Terry Galloway, Contracting Officer via electronic mail at gallowaytl@mail.nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, contractors must be registered and have valid certification in the Central Contractor Registration (CCR) and the Online Representations and Certifications Applications (ORCA) through sam.gov. Reference: NCI130148-TG on all correspondence.
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- Record
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