SOLICITATION NOTICE
59 -- HiSeq 2000 to HiSeq 2500 upgrade
- Notice Date
- 9/13/2013
- Notice Type
- Presolicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- HHS-NIH-NHLBI-CSB-(AR)-2013-302-RMD
- Archive Date
- 9/19/2013
- Point of Contact
- Renee Dougherty, Phone: 301-435-7920, Lisa Portner, Phone: 3014350326
- E-Mail Address
-
dougherr@nhlbi.nih.gov, Lisa.Portner@nih.gov
(dougherr@nhlbi.nih.gov, Lisa.Portner@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS INTRODUCTION THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). The National Heart, Lung, and Blood Institute (NHLBI), Office of Acquisitions (OA) on behalf of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) intends to negotiate and award a purchase order without providing for full and open competition (Including brand-name) to Illumina, Inc. 9885 Towne Centre Drive, San Diego, California 92121-1975 for a HiSeq 2000 to HiSeq 2500 upgrade. NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE The intended procurement is classified under NAICS code 334516 with a Size Standard of 500. REGULATORY AUTHORITY The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2005-69 effective September 3, 2013. This acquisition is conducted under the procedures as prescribed in FAR subpart 13-Simplified Acquisition Procedures at an amount not exceeding the simplified acquisition threshold ($150,000). STATUTORY AUTHORITY This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures, Subpart 13.106-1 (b) (1), Soliciting from a single source and is not expected to exceed the simplified acquisition threshold. Contracts awarded using FAR Part 13-Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6-Competition Requirements. DESCRIPTION OF REQUIREMENT The Genome Analysis Core Facility within the National Institute of Arthritis and Muskuloskeletal and Skin Diseases (NIAMS) requests the purchase of a hardware upgrade for the Illumina HiSeq 2000 (S/N 7001365) with NIH Decal No.01696570. The upgrade from HiSeq 2000 to HiSeq 2500 is a hardware and software upgrade that will allow the HiSeq 2000 to perform to the following HiSeq 2500 specifications:. HiSeq 2500 System Performance Parameters High Output Run Mode* Rapid Run Mode* Read Length Dual Flow Cell Single Flow Cell Dual Flow Cell Run Time Dual Flow Cell (HiSeq 2500 only) Single Flow Cell (HiSeq 1500 or 2500) Dual Flow Cell Run Time 1 x 36 95-105 Gb 47-52 Gb 2 days 18-22 Gb 9-11 Gb 7 hr 2 × 50 270-300 Gb 135-150 Gb 5.5 days 50-60 Gb 25-30 Gb 16 hr 2 x 100 540-600 Gb 270-300 Gb 11 days 100-120 Gb 50-60 Gb 27 hr 2 x 150 N/A N/A N/A 150-180 Gb 75-90 Gb 40 hr Reads Passing Filter Up to 3 billion single reads or 6 billion paired-end reads Up to 1.5 billion single reads or 3 billion paired-end reads Up to 600 million single reads or 1.2 billion paired-end reads Up to 300 million single reads or 600 million paired-end reads Quality Greater than 85% of bases above Q30 at 2 × 50 bp Greater than 80% of bases above Q30 at 2 × 100 bp Greater than 85% of bases above Q30 at 2 × 50 bp Greater than 80% of bases above Q30 at 2 × 100 bp Greater than 75% of bases above Q30 at 2 × 150 bp Background The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Genome Analysis Core Facility, is charged with providing genome-scale high throughput data generation for researchers within the Institute. The Illumina HiSeq 2000 is a very powerful high throughput sequencing instrument used in several research projects carried out at NIAMS aimed at better understanding the genetic determinants of autoimmune, auto inflammatory and musculoskeletal diseases and gain insights into the pathogenesis of genetic and immunologic diseases. The Illumina technology has proven in the past to ideally serve the needs of NIAMS investigators, is the dominant technology of its type on the market today, and there is no competing technology that meets the variable demands and variety of applications currently employed by NIAMS researchers. The HiSeq 2000 to HiSeq 2500 upgrade will be a very powerful tool to continue research projects carried out at NIAMS aimed at better understanding the genetic determinants of autoimmune, auto inflammatory and musculoskeletal and skin diseases. Illumina is the only company that can perform the HiSeq 2000 to HiSeq 2500 upgrade using the original parts and software. Purpose and Objectives The Genome Analysis Core Facility within NIAMS requests the purchase of a hardware upgrade for the Illumina HiSeq 2000 (S/N 7001365) with NIH Decal No.01696570. The upgrade from HiSeq 2000 to HiSeq 2500 is a hardware and software upgrade that will allow the HiSeq 2000 to perform to the HiSeq 2500 specifications Period of Performance This is a fixed price purchase and delivery will be up to 60 days from award. Project Description The Genome Analysis Core Facility within NIAMS requests the purchase of a hardware upgrade for the Illumina HiSeq 2000 (S/N 7001365) with NIH Decal No.01696570. The upgrade from HiSeq 2000 to HiSeq 2500 is a hardware and software upgrade that will allow the HiSeq 2000 to perform to the HiSeq 2500 specifications The HiSeq 2500 system is the latest addition to the revolutionary HiSeq family of sequencers. Based on the same core architecture as the groundbreaking HiSeq 2000, and with advancements in cycle time reduction and onboard cluster generation originally developed for the MiSeq system. The HiSeq 2500 can be switched between a high output run mode and rapid turnaround run mode. In high output mode, the HiSeq 2500 enables sequencing of a large number of genomes, exomes, or transcriptomes in a single run, allowing large studies to be completed with the fewest number of runs. In rapid run mode, the HiSeq 2500 is capable of sequencing a 30×genome in a day or completing or fast multiplexed applications such as exome resequencing or RNA-Seq. The rapid run time includes automated, on-instrument cluster generation, and paired-end sequencing, with no user intervention needed throughout the entire process. The HiSeq 2500 has revolutionized the speed at which whole human genome scale sequencing can be performed. Rapid turnaround time combined with superior data quality is critical for situations where quick answers are needed with the highest level of confidence. In fast turnaround mode, a whole human genome can be easily prepared and sequenced on HiSeq 2500 in approximately 1/10 of the time previously needed on a HiSeq 2000. The HiSeq 2500 will allow samples to be analyzed on a small scale that allows for a two day experiment timeline rather than a 3 week timeline. Aside from the speed and quality of whole-genome sequencing, the HiSeq 2500 delivers experimental flexibility, empowering fast multiplexed exome and targeted resequencing applications, short read experiments in a single working day, and rapid turnaround time for the core facilities iterative and optimization experiments. In the last couple of years, more and more of our institute investigators are using the services of our Genome Analysis Core Facility to apply the technology to their numerous research projects, this has resulted in a demand for machine time and data output. We are anticipating the need and we are requesting the acquisition of the upgrade from HiSeq 2000 to HiSeq 2500. The upgraded instrument will increase our sequencing throughput potential and will accommodate the present and future needs of our NIAMS investigators. Other Important Considerations This is a hardware and software upgrade to an existing piece of scientific equipment. The upgrade must be compatible with the Illumina HiSeq 2000 and must be Illumina catalog part #SY-401-1003. This upgrade must be covered under the current service contract of the HiSeq 2000 (S/N 7001365) and NIH Decal No.01696570. CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME) DETERMINATION The determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted as prescribed in FAR Part 10-Market Research. In conclusion the findings are that Illumina, Inc., is the sole manufacturer of the upgrade to the HiSeq 2000 sequencing system. The parts are unique to these instruments and cannot be substituted by other vendor parts. (Sole Source Letter from manufacturer has been provided.) CLOSING STATEMENT This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by Wednesday, September 18, 2013, at 3:00 p.m. EST and must reference number HHS-NIH-NHLBI-CSB-(AR)-2013-302-RMD. Responses may be submitted electronically to Renee Dougherty (dougherr@nhlbi.nih.gov) or by U.S. mail to the National Heart, Lung, and Blood Institute, Office of Acquisitions, COAC Services Branch,6701 Rockledge Drive, Suite 6042, Bethesda, MD 20892-7902, Attention: Renee Dougherty. Fax responses will not be accepted. "All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/HHS-NIH-NHLBI-CSB-(AR)-2013-302-RMD/listing.html)
- Place of Performance
- Address: National Institutes of Health, Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN03188023-W 20130915/130913235912-004444a15ca7536cbd5e2c9b63c912a2 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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