SOLICITATION NOTICE
66 -- HiSeq 2500 Sequencing System
- Notice Date
- 4/21/2014
- Notice Type
- Presolicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NIH-NHLBI-CSB-(HG)-2014-099-DLM
- Archive Date
- 5/10/2014
- Point of Contact
- Dorothy Maxwell, Phone: 301-435-0352
- E-Mail Address
-
maxwelld@mail.nih.gov
(maxwelld@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- INTRODUCTION: THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A CONTRACT WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR A PROPOSAL. A SOLICITATION DOCUMENT WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Heart, Lung, and Blood Institute (NHLBI) Office of Acquisition (OA) on behalf of the National Human Genome Research Institute, (NHGRI), intends to negotiate and award a purchase order on a noncompetitive sole source basis to Illumina Inc., 9885 Towne Centre Drive, San Diego, California 92121-1975. (BRAND-NAME: ILLUMINA HiSeq 2500 SEQUENCING SYSTEM) Procurement : 1. HiSeq 2500, Catalog Number: SY-401-2501, Quantity: One (1). 2. Shipping and Insurance. BACKGROUND : The National Institute of Health (NIH) mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The National Human Genome Research Institute (NHGRI) mission has expanded to encompass a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. NHGRI supports the development of resources and technology that will accelerate genome research and its application to human health. A critical part of the NHGRI mission continues to be the study of the ethical, legal and social implications (ELSI) of genome research. NHGRI also supports the training of investigators and the dissemination of genome information to the public and to health professionals. The NHGRI/NIH Intramural Sequencing Center (NISC) is a high-throughput sequencing center supporting all institutes within the NIH. NISC has served the NIH community for over 15 years as a source for high-quality large-scale sequencing and analysis. As next generation sequencing applications expand, so does the demand for our services. NISC currently have 3 HiSeq2000 sequencers in full operation and NHGRI forecast is for a significant increase over the next 6 months. Since the Sequencing Center is nearly at capacity, the Center will need an additional sequencer to meet high demand. Additionally, NISC will need capability to process certain samples very quickly, which will allow for physicians to get an appropriate turn-around time on results. The HiSeq2500 System provides ultra-high output and speed. In a single run one is able to sequence more than 5 human genomes at ~30x coverage. It is able to process a diverse set of samples within one flow cell, and with the highest data quality currently available. Another key factor in this selection is that this instrument is able to run in an alternate rapid mode which would allow us to decrease our turnaround time by many weeks. This is a critical consideration for projects impacting patient diagnosis. PERIOD OF PERFORMANCE : • HiSeq 2500 Sequencing System will be delivered within 4-6-weeks of receiving the approved contract award. PROJECT DESCRIPTION The NIH Intramural Sequencing Center (NISC), established in 1997, is a multi-disciplinary genomics facility that emphasizes the generation and analysis of DNA sequence. In addition to providing investigators at the NIH access to large-scale DNA sequencing, NISC plays a major role in several efforts related to the Human Genome Project including a Comparative Vertebrate Sequencing Initiative, the ENCODE Project, and the Mammalian Gene Collection Program. NISC is also an active participant in the International Sequencing Consortium. While it is currently feasible to sequence an entire genome it is quite expensive and unwieldy. When an investigator wishes to study only selected genes or genomic regions it is more cost-effective and efficient to perform targeted sequencing. Over the past 2.5 years NISC has invested significant resources to develop a state of the art data analysis pipeline based on the Illumina family of sequencers. NISC would have to expend additional money in labor and possibly hardware to redevelop the process and integrate a new instrument. NHGRI/NISC has extensive experience with all other high-throughput sequencing platforms. The HiSeq 2500 also allows researchers to process samples by a single method that is compatible with HiSeq 2000. This simplifies the NISC lab processes, minimizing labor and equipment costs, and gives researchers the flexibility to route samples to either machine type depending on the needs of the project and machine availability. The high speed of the HiSeq 2500, means that reagents sit out for a shorter period of time and decay to a lesser degree during the run. The result is longer, more accurate reads (300 vs. 200 bases). This allows NISC to expand the sequencing applications supported on this platform, as some supplications require longer reads. Contractor Requirements : • Must be able to run the same chemistry as HiSeq 2000, MiSeq, and Genome Analyzer IIx Systems. • Run time for 200 base run must be under 30 hours. • Data should be able to be processed through NISC's data analysis software. • Preparation time for samples to load on the sequencer should take about a day. • Read length at least 150 bp. • Produce paired-end reads of 60 million per run. • Reagents are in convenient volumes and are ready-to-load. • Oil is not required for the optics. • Straightforward protocols that require no beads or emulsions. • System should be able to perform amplification, sequencing and data analysis in one unit. Government Responsibilities : Not applicable Reporting Requirements and Deliverables : Not Applicable Program Management and Control Requirements : Not applicable Inspection and Acceptance Requirements: • Upon arrival of equipment to destination, the package must be undamaged. • In the installation of the equipment, all parts including computer must be functional and running in proper order. REGULATORY AUTHORITY This acquisition is conducted under the authority of 41 U.S.C. 253(c) as set forth in FAR Part 6.302-1, only one responsible source and no other supplies or services will satisfy agency requirements. ADDITIONAL INFORMATION Industry Classification (NAICS) Code is 334516, Analytical Laboratory Instrument Manufacturing and the Small Business Size Standard is 500 Employees. The acquisition is being conducted under FAR Part 13, simplified acquisition procedures, therefore the requirements of FAR Part 6 B Competitive Requirements are not applicable (FAR Part 6.001). The resultant Contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 05-72 (January 30, 2014). This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by April 25, 2014 and must reference synopsis number HHS-NIH-NHLBI-CSB-(HG)-2014-099-DLM, may be submitted to the National, Heart, Lung and Blood Institute, Office of Acquisition, COAC Services Branch, 6701 Rockledge Drive, Suite 6149, Bethesda, Maryland 20892-7902, Attention: Dorothy Maxwell. Response may be submitted electronically to maxwelld@mail.nih.gov. Faxes will not be accepted. Responses will only be accepted if dated and signed by an authorized company representative. "All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/NIH-NHLBI-CSB-(HG)-2014-099-DLM/listing.html)
- Place of Performance
- Address: NIH/5625 Fishers Lane, NISC Center, Rockville, Maryland, 20852, United States
- Zip Code: 20852
- Zip Code: 20852
- Record
- SN03344347-W 20140423/140421234825-a5c6e5f6e0f7407fa4587c01d0c5818a (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |