SOLICITATION NOTICE
B -- FRACKING: TOXICOLOGICAL EFFECTS OF SILICA & DIESEL EXHAUST EXPOSURE
- Notice Date
- 5/27/2014
- Notice Type
- Presolicitation
- NAICS
- 611310
— Colleges, Universities, and Professional Schools
- Contracting Office
- Department of Health and Human Services, Centers for Disease Control and Prevention, Acquisition and Assistance Field Branch (Morgantown), 1095 Willowdale Road, Morgantown, West Virginia, 26505
- ZIP Code
- 26505
- Solicitation Number
- 000HCCCB-2014-72838
- Archive Date
- 7/11/2014
- Point of Contact
- Rebecca S Mullenax, Phone: 304-285-5880, Denise Rains, Phone: 509-354-8111
- E-Mail Address
-
rmullenax@cdc.gov, dgr8@cdc.gov
(rmullenax@cdc.gov, dgr8@cdc.gov)
- Small Business Set-Aside
- N/A
- Description
- Sole Source FBO Notice for Procurement Request 000HCCCB-2014-72838 Title: Fracking: Toxicological Effect s of Silica and Diesel Exhaust Exposure The Centers for Disease Control and Prevention (CDC) and the National Institute for Occupational Safety and Health (NIOSH), Toxicology and Molecular Biology Branch (TMBB), Health Effects Laboratory Division (HELD) intends to award a sole source firm fixed price purchase order to West Virginia University Research Corporation, 866 Chestnut Ridge Road, Morgantown, WV 26506 to isolate RNA from rats exposed to silica and diesel exhaust particles. Clin 1: Quantity of (1) project - RNA Sequencing: TruSeq RNA library prep, quality control, secquencing run on HiSeq instrument. STATEMENT OF WORK Title of Project: Fracking: Toxicological Effects of Silica and Diesel Exhaust Exposure Background and Need The services contemplated under this contract are considered to be an "Other Function" as defined by the Office of Federal Procurement Policy in OFPP letter 11‐01 and by HHS in Acquisition Policy Memorandum 2012‐01. Illumina's next generation sequencing is a cutting edge technique and one of its applications is the determination of global gene expression profile in biological samples. It is very well understood that global gene expression profile in biological samples change in response to exposure to toxic agents. Therefore, determination of global gene expression changes in response to exposure to a toxic agent and further analysis of the gene expression data will result in the identification of mechanisms potentially underlying the toxicity of the agents being studied. The next generation sequencing service will help us to obtain global gene expression data required to understand the molecular mechanisms underlying the toxicity of silica and diesel exhaust particles. Our lab or any other lab at NIOSH, Morgantown, does not have the facility to do next generation sequencing or any other technique that can be employed to determine global gene expression profile in biological samples. Project Objective The project objective is to determine the molecular mechanisms underlying the toxicity due to exposure to silica and diesel exhaust particles in a rat toxicity model. Scope of Work The Molecular Carcinogenesis Laboratory will isolate RNA from rats exposed to silica and diesel exhaust particles. These RNA samples will then be sent to Genomics Sequencing Core, Biology Department, Eberly College of Arts and Sciences, West Virginia University dba WVU Research Corporation to determine the gene expression profile by next generation sequencing technique. The results will then be delivered electronically to the P.I. / Molecular Carcinogenesis Laboratory for further analysis. Technical Requirements Genomics Sequencing Core, Biology Department, Eberly College of Arts and Sciences, West Virginia University will supply all reagents, etc. and perform next generation sequencing using the next generation sequencing system. The results will be delivered electronically to the P.I. / Molecular Carcinogenesis Laboratory. Reporting Schedule The results will be delivered electronically to the P.I. / Molecular Carcinogenesis Laboratory upon completion of the work. Deliverables The RNA samples will be personally delivered to the Genomics Sequencing Core, Biology Department, Eberly College of Arts and Sciences, West Virginia University by the PI or another member of the Molecular Carcinogenesis Laboratory. The Genomics Sequencing Core will perform next generation sequencing and the resulting data will be processed. The raw and processed data will be delivered electronically to the PI, Molecular Carcinogenesis Laboratory one year after the starting date of the service. This contract action is for a product for which the government intends to solicit and negotiate with only one source under the authority of FAR 13.106-1(b) and 10 U.S.C 2304(c) (1). Interested persons may identify their interest and capability to respond to the requirement or submit proposals. The notice of intent is not a request for competitive quotations; however, all quotations/responses received within (15) days of the issuance of this notice will be considered by the Government. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will normally be considered solely for the purpose of determining whether to conduct a competitive procurement. Any quotation/response should be e-mailed to purchasing agent Rebecca Mullenax at rmullenax@cdc.gov by 11:59 p.m. Eastern time on June 11, 2014. FAR Reference: FAR 5.207 - Preparation and transmittal of synopses under (c) (15), (c) (16) (i) and (c) (16) (ii).
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/CDCP/MNIOSH/000HCCCB-2014-72838/listing.html)
- Record
- SN03376747-W 20140529/140527234530-79d94407fb43e6371cff5192ebf16924 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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