SOLICITATION NOTICE
B -- Ayrris Pipeline analysis covering up to 60 whole genomes
- Notice Date
- 5/27/2014
- Notice Type
- Presolicitation
- NAICS
- 541711
— Research and Development in Biotechnology
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NIH-HHS-NHLBI-CSB-(HG)-2014-142-DLM
- Archive Date
- 6/17/2014
- Point of Contact
- Dorothy Maxwell, Phone: 301-435-0352
- E-Mail Address
-
maxwelld@mail.nih.gov
(maxwelld@mail.nih.gov)
- Small Business Set-Aside
- Total Small Business
- Description
- INTRODUCTION : The National Institute of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) Office of Acquisition (OA) on behalf of the National Human Genome Research Institute, (NHGRI), intends to negotiate and award a purchase order on a non-competitive sole source basis to Appistry Inc., 1141 South 7th Street, Suite 300, St. Louis, MO 63104 to procure the following: PROCUREMENT : 1. Service runs and analysis covering up to 60 whole genomes, Quantity: up to Sixty (60). BACKGROUND: The National Institutes of Health (NIH) mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The National Human Genome Research Institute (NHGRI) mission has expanded to encompass a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. NHGRI Undiagnosed Disease Program (UDP) is a trans-National Institute of Health (NIH) initiative that focuses on the most puzzling medical cases referred to the NIH Clinical Center in Bethesda, MD. Many medical specialties from other NIH research centers and institutes contribute the expertise needed to conduct the program, including endocrinology, immunology, oncology, dermatology, dentistry, cardiology and genetics, among the dozens of participating senior attending physicians. A longstanding medical condition that eludes diagnosis by a referring physician can be considered undiagnosed and may be of interest to this clinical research program. Genomic DNA will be isolated from all admitted Undiagnosed Diseases patients and family members. Depending on the phenotype of the patient, these DNA samples will be sent for exome sequencing as the first step to obtain variant information that may determine the mechanism of the patients' disease. It is necessary for the Undiagnosed Diseases Laboratory to then perform extensive analyses on the large amount of exome sequencing and variant data that s generated in a timely manner to facilitate genetic studies when combined with SNP analysis. This information will then be used to perform research experiments to discern the genetic and molecular basis of the unique disease of the patient. PURPOSE AND OBJECTIVES : Appistry Ayrris has been integrated with the RURO LIMS 24/7 system that allows for a continuous pipeline that makes collecting, storing, managing and routing data simple, reliable and efficient. This has enabled the NIH UDP laboratory to establish and maintain a full change of custody for samples and associated data across the experimental life cycle, standardize physical and digital processes to achieve compliance with specific regulations, and create production-grade workflows necessary for the laboratory. They have executed the NIH UDP Diploid-Alignment Pipeline on Ayrris and integrated this pipeline within LIMS 24/7 that allows users to monitor the progress of the pipelines without requiring detailed knowledge of how the pipeline is executing. Appistry has currently developed this pipeline in collaboration with the NIH UDP and will continue to perform these analyses with the UDP that is generated by sequencing UDP patient exomes. This procurement will allow Appistry to adapt the pipeline to include whole genome analysis and integrate the updates in LIMS 24/7. PERIOD OF PERFORMANCE : Twelve (12) months from the date of award. REGULATORY AUTHORITY : This acquisition is conducted under the authority of the Federal Acquisition Regulations (FAR) Subpart 13.106-1(b) Soliciting from a single source, only one responsible source and no other supplies or services will satisfy agency requirements. ADDITIONAL INFORMATION: Industry Classification (NAICS) Code is 541711, Research and Development in Biotechology, small business size standard is 500. The acquisition is being conducted under FAR Part 13, simplified acquisition procedures, therefore the requirements of FAR Part 6 B Competitive Requirements are not applicable (FAR Part 6.001). The resultant Contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 05-73 (April 29, 2014). This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by June 2, 2014 and must reference synopsis number HHS-NIH- NHLBI-CSB-(HG)-2014-142-DLM, may be submitted to the National, Heart, Lung and Blood Institute, Office of Acquisition, COAC Services Branch, 6701 Rockledge Drive, Suite 6149, Bethesda, Maryland 20892-7902, Attention: Dorothy Maxwell. Response may be submitted electronically to maxwelld@mail.nih.gov. Faxes will not be accepted. Responses will only be accepted if dated and signed by an authorized company representative. "All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/NIH-HHS-NHLBI-CSB-(HG)-2014-142-DLM/listing.html)
- Place of Performance
- Address: Contractor's and NIH Location, United States
- Record
- SN03377092-W 20140529/140527234834-e1c49070790d2d93b6d3e6e4361c3b85 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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