SOLICITATION NOTICE
R -- Evaluation of a Thermostable Microneedle Patch for Measles Vaccination to Overcome Inhibition from Maternal Antibody
- Notice Date
- 7/31/2014
- Notice Type
- Presolicitation
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, Centers for Disease Control and Prevention, Procurement and Grants Office (Atlanta), 2920 Brandywine Road, Room 3000, Atlanta, Georgia, 30341-4146
- ZIP Code
- 30341-4146
- Solicitation Number
- 2014-N-16635
- Archive Date
- 9/1/2015
- Point of Contact
- Monica D. Shaw, Phone: 7704888213
- E-Mail Address
-
monica.shaw@cdc.hhs.gov
(monica.shaw@cdc.hhs.gov)
- Small Business Set-Aside
- N/A
- Description
- THIS NOTICE IS FOR INFORMATIONAL PURPOSES ONLY. The Centers for Disease Control and Prevention (CDC), National Center for Immunization and Respiratory Diseases (NCIRD), contemplate award of a Firm Fixed Price Sole Source Contract to the University of California. The work shall be performed at the Contractor's facility. The Period of Performance shall be for 12 months. The North American Industrial Classification Standards (NAICS) Code is 541990 and Standard Business Size of $15M. Contract #200-2014-60103, Line Item #1 will be awarded to the University of California by 8/21/2015. The sole source award will be conducted in accordance with FAR Part 6.302-1 only one responsible source and no other supplies or services will satisfy agency requirement. This requirement is new requirement. To reduce measles morbidity and mortality, this project has two long-term goals: to improve measles vaccine immunogenicity by targeting vaccine delivery to the skin and to improve measles vaccination coverage by simplifying logistics of mass vaccination using a microneedle patch. Although measles vaccine is highly efficacious in older children and adults, vaccination of infants under the age of 9 months is much less effective due to inhibition of the immune response by maternal antibodies. Previous studies by our collaborators and others have shown that skin vaccination generates qualitatively and quantitatively different and more robust immune responses compared to subcutaneous or intramuscular vaccination of a number of different vaccines. This study will test the hypothesis that skin vaccination using a microneedle patch in infant rhesus macaques with maternal antibody generates a strong immune response that is protective against live measles virus challenge. In that context, this study will also test the hypothesis that a microneedle patch can be developed to (i) administer a full human dose of measles and rubella vaccines, (ii) maintain vaccine activity after extended storage at elevated temperature, (iii) enable simple administration with minimal training and (iv) generate no sharps waste after use in order to simplify logistics of mass vaccination and thereby increase vaccination coverage. The overall goal is to develop a thermostable MR patch for simple skin vaccination and assess protective efficacy of measles vaccination in the infant rhesus macaque with maternal antibody. Non-human primates are a good model to evaluate the immunogenicity of measles vaccines. Rubella vaccine will also generate an immune response in non-human primates. CDC is not requesting competitive proposals and no solicitation is available. Firms that believe they can provide the services required are encouraged to identify themselves and give written notification to the Contracting Officer no later than 2:00 PM Eastern Standard Time, by August 17, 2014. Determination not to compete this proposed action based on responses to this notice is solely within the discretion of the Government. Respondents will assume all financial costs for preparing a response to this notice. The U.S. Government assumes no financial obligation for the preparation and distribution of prepared responses. Inquiries may be sent to Monica Shaw via email at vwk1@cdc.gov.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/CDCP/PGOA/2014-N-16635/listing.html)
- Place of Performance
- Address: University of California - Davis, California National Primate Research Center, County Road 98 and Hutchison Drive, Davis, California, 95616-8542, United States
- Zip Code: 95616-8542
- Zip Code: 95616-8542
- Record
- SN03445278-W 20140802/140731235848-0137e3833517dbd99981e4cfc70b4ce9 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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