SOLICITATION NOTICE
B -- Application of Statistical Methods to Calibrate and Season-Adjust Circulating Vitamin D Data Collected for the Pooling Project of Breast and Colorectal Cancer
- Notice Date
- 8/8/2014
- Notice Type
- Presolicitation
- NAICS
- 541690
— Other Scientific and Technical Consulting Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E128, Rockville, Maryland, 20852, United States
- ZIP Code
- 20852
- Solicitation Number
- N02CP42615-24
- Archive Date
- 9/9/2014
- Point of Contact
- Terry Galloway, Phone: 240-276-5384, Seena Ninan, Phone: 240-276-5419
- E-Mail Address
-
gallowaytl@mail.nih.gov, ninans@mail.nih.gov
(gallowaytl@mail.nih.gov, ninans@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Contracting Office Address Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E626, Bethesda, MD 20892, UNITED STATES Description The National Cancer Institute (NCI), Division of Hormonal and Reproductive Epidemiology Branch (HREB) plans to procure on a sole source basis services for the application of statistical methods to calibrate and season-adjust circulating Vitamin D data collected for the Pooling Project of Breast and Colorectal Cancer from Harvard School of Public Health, 665 Huntington Avenue, Boston MA 02115-6021, USA. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1) and is exempt from the requirements of FAR Part 6. The North American Industry Classification System code is 541690 and the business size standard is $14.0 Million. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. The period of performance is twelve (12) months from date of award. It has been determined there are no opportunities to acquire green products or services for this procurement. The National Cancer Institute is pooling individual data on circulating 25-hydroxyvitamin D [25(OH)D], the accepted measure of vitamin D status, from 21 cohorts, which includes practically all the prospective data available worldwide. For some of the cohorts, the NCI measured 25(OH)D using a common laboratory and assay. For the other cohorts, which had already assayed their blood samples for 25(OH)D, there is a need to calibrate their assays, conducted in different laboratories with different techniques, to the current assay. In addition, 25(OH)D concentrations vary substantially throughout the year, with values peaking in the summer and dropping substantially during the winter. Therefore, the National Cancer Institute needs to season-adjust the 25(OH)D data so that controls are matched to the cases in each cohort and the various cohorts are comparable. In this pooling project, the NCI is analyzing absolute 25(OH)D concentrations, not study-specific quantiles, in order to examine risk over the full range of vitamin D exposure present around the world and to facilitate translation of results into clinical guidelines and public health guidance. This challenging approach has led to the development by NCI biostatisticians of novel statistical methods for calibration and adjustment for date of blood draw. These methods are necessary so that we can work with comparable absolute 25(OH)D concentrations from the various cohorts. These statistical methods and their application in the Vitamin D Pooling Project are serving as a model for other biomarker cohort consortia that will combine data from different assays conducted by different labs. This procurement has four objectives: 1) To apply statistical methods recently developed by NCI biostatisticians for calibrating 25(OH)D concentrations measured by a variety of assays conducted at different times in different laboratories to the circulating 25(OH)D data collected from colorectal cancer studies participating in the Vitamin D Pooling Project of Breast and Colorectal Cancer. 2) To apply the statistical methods recently developed by NCI biostatisticians for calibrating 25(OH)D concentrations measured by a variety of assays conducted at different times in different laboratories to the circulating 25(OH)D data collected from breast cancer studies participating in the Vitamin D Pooling Project of Breast and Colorectal Cancer. 3) To apply the statistical methods recently developed by NCI biostatisticians for adjusting for seasonal variation 25(OH)D concentrations measured in blood samples collected throughout the year to the circulating 25(OH)D data collected from colorectal cancer studies participating in the Vitamin D Pooling Project of Breast and Colorectal Cancer. 4) To apply the statistical methods recently developed by NCI biostatisticians for adjusting for seasonal variation 25(OH)D concentrations measured in blood samples collected throughout the year to the circulating 25(OH)D data collected from breast cancer studies participating in the Vitamin D Pooling Project of Breast and Colorectal Cancer. The circulating 25(OH)D data, along with cancer outcomes and covariates, from the 21 cohorts participating in the Vitamin D Pooling Project of Breast and Colorectal Cancer has been sent to Harvard School of Public Health, stored on Harvard computer servers, and cleaned up and harmonized by Harvard staff under the direction of Dr. Stephanie Smith-Warner. The data transfer agreements signed with the various cohorts specified that the participant data had to remain on the Harvard computer servers and be analyzed under the direction of Dr. Smith-Warner. In particular, these agreements specified how the data would be anonymized. Therefore, the only institution with all the Vitamin D Pooling Project data and able to apply the statistical methods developed at NCI required for the analysis of the data is Harvard School of Public Health. This notice is not a request for competitive quotation. However, if any interested party, especially small businesses, believes it can meet the above requirement, it may submit a capability statement, proposal, or quotation, which shall be considered by the agency. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 3:00 PM EST, on August 25, 2014. All responses and questions must be in writing and faxed 240-276-5401 or emailed to Kimesha Leake, Contract Specialist via electronic mail at Kimesha.leake@nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, contractors must be registered and have valid certification in the System for Award Management (SAM) through sam.gov. Reference: N02CP42615-24 on all correspondence.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/RCB/N02CP42615-24/listing.html)
- Record
- SN03458128-W 20140810/140808235303-f94cf6b8a6abc7eef642445462869aac (fbodaily.com)
- Source
-
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