SOLICITATION NOTICE
R -- Mass spectrometry for analysis of change from acetylation of proteins in tissue samples
- Notice Date
- 8/15/2014
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-CSS-14-606
- Archive Date
- 9/4/2014
- Point of Contact
- Hunter A. Tjugum, Phone: 301 435 8780, ,
- E-Mail Address
-
hunter.tjugum@nih.gov, NIDASSSAPurchaseRequ@mail.nih.gov
(hunter.tjugum@nih.gov, NIDASSSAPurchaseRequ@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. This acquisition is being conducted in accordance with the procedures of FAR Part 13-Simplified Acquisition Procedures, FAR Subpart 13.5-Test Program for Certain Commercial Items, and FAR Part 12-Acquisition of Commercial Items. The solicitation number is HHS-NIH-NIDA-(SSSA)-CSS-14-606 and the solicitation is issued as a pre-solicitation notice of intent to award a contract on a noncompetitive basis to Johns Hopkins School of Medicine located at 733 N. Broadway Street in Baltimore, MD 21205-2185. This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures, Subpart 13.106-1 (b) (1), Soliciting from a single source and is not expected to exceed the simplified acquisition threshold. Contracts awarded using FAR Part 13-Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6-Competition Requirements. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-76, dated 25 JULY 2014. The associated NAICS code for this requirement is 541990 All Other Professional, Scientific and Technical Services with associated small business size standard $14.0 million. DESCRIPTION Background, purpose, and objectives: The National Institute on Aging (NIA), one of the 27 Institutes and Centers of NIH, leads a broad scientific effort to understand the nature of aging and to extend the healthy, active years of life. The Intramural Research Program (IRP) in the NIA consists of the Laboratory of Cardiovascular Science (LSC), which is driven by the following mission goals: (1) to identify age-associated changes that occur within the cardiovascular system and to determine the mechanisms for these changes; (2) to determine how aging of the heart and vasculature interacts with chronic disease states to enhance the risk for CV diseases in older persons; (3) to study basic mechanisms in excitation-contraction coupling in cardiac cells and how these are modulated by surface receptor signaling pathways; (4) to elucidate factors that maintain stem cell pluripotentiality, that promote the commitment of stem cells to the cardiac lineage, and that regulate their development as cardiac cells; (5) to elucidate mechanisms that govern cardiac and vascular cell survival; (6) to determine mechanisms that govern neuro-hormonal behavioral aspects of hypertension; and (7) to establish the potentials and limitations of new therapeutic approaches such as changes in lifestyle, novel pharmacologic agents or gene or stem cell transfer techniques in aging or cardiovascular disease states. In meeting these objectives, studies are performed in human volunteers, intact animals, isolated heart and vascular tissues, isolated cardiac and vascular cells, and subcellular organelles. The rate of aging is not fixed and can be modified in both positive and negative ways by environmental factors. The LCS is interested to elucidate certain key biochemical signals regulating healthy vs unhealthy aging, and this can be achieved, in part, by measuring certain covalent changes to a broad spectrum of cellular proteins. General Scope of Work Contractor shall compare the changes in acetylation of proteins in three different subcellular compartments (cytosol, nuclear and mitochondria) from a control group and up to 9 main treatment groups for the comparison. The goal is to identify the common overlap of the various treatment-related distributions of acetylated proteins. Three TMT 1 0-plex experiments will be required to compare 10 samples (control and 9 treatment groups) from 3 different subcellular compartments (cytosol, nuclear and mitochondria). A total of 40 samples will be analyzed. Scope of Work includes sample processing of antibody enrichment, mass tag labeling, fractionation, and Proteolysis for PTM enrichment, and mass spectrometry. Contractor's requirements The Contractor shall perform and analyze mass spectrometry and peptides to compare the changes in acetylation of proteins in live tissue sample. Delivery of samples shall be made within 30 minutes of sample preparation to prohibit deterioration of sample otherwise resulting. Contractor shall access sample from the NIA government facility located at 251 Bayview Blvd, Baltimore, MD directly to the proteomics facility of the contractor for immediate proteomic analysis of that sample. Technical Evaluation criteria Offerors will be evaluated on ability to meet the essential government requirements contained in this announcement. Offerors will be evaluated on ability to fulfill all technical and functional specifications and contractor requirements necessary to accomplish the statement of work. This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. Responses to this solicitation must include clear and convincing evidence of the Offeror's capability of fulfilling the requirement as it relates to the technical evaluation criteria. The price proposal must include an estimate of the number of labor hours required; cost breakdown and rationale for other direct costs or materials; and the total amount. The following FAR provisions shall apply to this solicitation: 52.212-1, Instructions to Offerors--Commercial Items, 52.212-2, Evaluation--Commercial Items. Evaluation factors that will be used to evaluate the offer most advantageous to the Government, price and other factors considered, include ability to meet the technical requirements stated in this pre-solicitation and on basis of best value to the government. Offerors must include a completed copy of the provision at 52.212-3, Offeror Representations and Certifications Commercial Items, with their offer. The Clause at 52.212-4, Contract Terms and Conditions Commercial Items, applies to this acquisition and the Clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders Commercial Items applies to this acquisition. Authority to add additional quantity of services at FAR 52.217-6 Option for Increased Quantity is applicable to this acquisition. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. In addition the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All Offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency. All responses must be received by August 20, 2014 at 12:00 pm, Eastern Standard Time (EST) and must reference solicitation number HHS-NIH-NIDA-SSSA-CSS-14-606. Responses may be submitted electronically to Hunter.Tjugum@nih.gov and to NIDASSSAPurchaseRequ@mail.nih.gov or by U.S. mail to the National Institute of Drug Abuse (NIDA), Station Support / Simplified Acquisition Branch (SS/SA), 31 Center Drive, Building 31, Room 1B59, Bethesda, Maryland 20892-2080, Attention: Hunter Tjugum. Fax responses will be accepted at (301) 480-1358. For information regarding this solicitation, contact Hunter Tjugum by email at hunter.tjugum@nih.gov or by phone at (301) 435-8780.
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