Loren Data's SAM Daily™

FBO DAILY - FEDBIZOPPS ISSUE OF AUGUST 22, 2014 FBO #4654
DOCUMENT

66 -- Waters SYNAPT G2-Si System or equal - Attachment

Notice Date

8/20/2014
 

Notice Type

Attachment
 

NAICS

334516 — Analytical Laboratory Instrument Manufacturing
 

Contracting Office

US Department of Veterans Affairs;Veterans Health Administration;Service Area Office (SAO) East;323 North Shore Drive, Suite 500;Pittsburgh PA 15212-5319
 

ZIP Code

15212-5319
 

Solicitation Number

VA24014R0087
 

Response Due

8/28/2014
 

Archive Date

9/12/2014
 

Point of Contact

Michael Haydo
 

Small Business Set-Aside

Total Small Business
 

Description

This is a PRE-SOLICITATION NOTICE of a proposed requirement for commercial "OFF THE SHELF" Mass Spectrometry System. This notice is issued solely for informational and planning purposes and no offers will be accepted. The requirement is for: 1. One (1) Each Waters Synapt G2-Si system to include all software and accessories necessary to install and ready for turn-key operation, or an equal item based on the salient characteristics. 2. One (1) Each Waters G2-S/Si system to include all software and accessories necessary to install and ready for turn-key operation or an equal item based on the salient characteristics. 3. Two (2) year maintenance package. 4. One Waters Synapt G2-Si MWS-HDMS software upgrade system to include all software and accessories necessary to install and ready for turn-key operation or an equal item based on the salient characteristics. Ionization Source: -The instrument shall be equipped with an atmospheric pressure ionization (API) interface that includes the source and spraying elements. -Samples may be introduced by direct infusion or the system may be interfaced directly to either a High Performance Liquid Chromatography/Ultra High Performance Liquid Chromatography (HPLC / UPLC) system or an Atmospheric Pressure Gas Chromatography (AP-GC) system. -The ion source shall be of dual orthogonal design. -The nebulized sprayer shall be positioned orthogonally to the sampling orifice and be positioned off-axis for maximum source longevity and analyzer protection against "dirty" samples. - The Liquid Chromatography (LC) inlet probe shall be positioned vertically to minimize system footprint, reduce length of connecting tubing and the potential for chromatographic peak broadening and be possible to introduce sample or calibrant solution, either directly or combined with the LC eluent, automatically via an integrated fluidics assembly. -A source access door with a viewable window shall be incorporated to allow easy access to the spraying elements for cleaning without the need to remove the ion source enclosure. -Tool free access to the ion source with a viewable window shall be incorporated to allow easy access for cleaning without the need to remove the ion source enclosure. - An isolation valve shall be fitted to the source to allow the source elements to be removed and cleaned without breaking instrument vacuum, therefore maximizing instrument uptime. -Removing and replacing the source elements shall be a tool-free operation. -The ion source shall include the facility to de-cluster ions formed at atmospheric pressure, and shall use standard laboratory grade nitrogen. -The de-solvation and cone gas shall be supplied via digitally controlled mass flow meters and be controlled via the data system. -All gas flows shall be fully integrated into the source so that no tubing connections are externally exposed. -Positive and negative ionization capabilities shall be included on the instrument. -All source voltages shall be under data system control and must incorporate active read backs. Ion Optics Element - A high efficiency T-wave device shall serve as an ion guide between the source and the analyzer. The T-wave based ion optics shall be available to maximize sensitivity whilst maintaining system robustness. Neutral molecules and gas load shall be actively exhausted while the ion beam is actively extracted into a parallel off axis T-Wave device for enhanced transmission and to enable focusing into the analyzer. Quadrupole Analyzer Element -The Quadrupole Analyzer shall be configured with a quadrupole mass filter for the efficient transmission of ions in the rf only MS mode and selection of precursor ions for MS/MS analysis, and be capable of unit mass resolution for precursor ion selection. -The Quadrupole Analyzer shall have the option of a 4kDa quadrupole operating at: 10 to 4000 m/z resolving mode or 20 to 16,000 m/z non-resolving mode. -The Quadrupole Analyzer shall have the option of an 8kDa quadrupole operating at: 20 to 8000 m/z resolving mode or 20 to 30,000 m/z non-resolving mode. -The Quadrupole Analyzer shall have the option of a 32kDa quadrupole option operating at: 100 to 32,000 m/z resolving mode. Ion Mobility Separation Module -The Ion Mobility Separation Module shall be configured with a TRIWAVE ion mobility separation device that incorporates a TRAP cell which has the following functionality; 1) accepts and accumulates ions that are produced in the source. 2) releases packets of ions for separation based on their ion mobility, and 3) can also act as a collision cell to fragment ions. -The TRIWAVE shall also incorporate a ION MOBILITY SEPARATION cell which has the following functionality; 1) can separate mixtures of ions are according to their ion mobility and with a resolution of over 40 ?/?? (cross-section/delta cross section), 2) ion mobility is based on several factors, the most important being the size, shape and charge of an ion; and 3) introduces an additional dimension of sample separation. Time of Flight (TOF) Mass Analyzer -The TOF system shall consist of an orthogonal acceleration time of flight mass spectrometer for MS and MS/MS analysis, consisting of the following components: 1) Prior to entering the TOF analyzer, the ion beam must be spatially and time focused using a series of digitally controlled lens and grids. 2) The ion beam must be injected (pulsed) orthogonally into the TOF analyzer at a repetition rate up to 30kHz and with an extraction field of up to 4kV. 3) One ion injection cell with two stage orthogonal acceleration system and a high precision two-stage reflectron. 4) One super-fast (sub-nanosecond) electron multiplier TOF detector. 5) Ion arrival times must be recorded using an analogue-to-digital converter (ADC) with an acquisition rate of 3 GSamples/sec to provide excellent peak definition and mass accuracy. 6) One additional ion mirror to allow a dual pass through the TOF. This folded geometry is termed 'High Resolution mode'. 7) The user must be able to easily select either a single or double pass geometries via the data system to provide spectral resolution >10000 FWHM (full width half maximum) or >20,000 FWHM in single pass mode (Sensitivity and Resolution modes) and >40,000 FWHM or 50,000 FWHM in dual pass mode (High Resolution and Enhanced Resolution modes). 8) The analyzer must have the capability of acquiring data with linearity of up to 5 orders of magnitude with a mass range of the analyzer must be up to 100,000 m/z in single pass mode and 32,000 m/z in dual pass mode, and able to acquire full spectral data at rates up to 30 spectra/sec. Following an instrument vent, nitrogen must be introduced to the TOF to protect the analyzer components from moisture build-up and thus minimize the time taken to pump the instrument to full working vacuum. Vacuum System -The Vacuum System shall incorporate a clean differentially pumped, automated vacuum system. There shall be a dual, oil free, vacuum backing pump option, and at least six (6) air-cooled turbo-molecular pumps. One for each of the source, quadrupole, transfer optics and oa-TOF regions of the instrument and two for the Triwave region of the instrument. -The system shall be equipped with analyzer penning vacuum gauges, vacuum read backs and system vent/pumps cycles should be digitally monitored to provide software control and ensure fail-safe operation in the event of power failure. Software Specifications -The computer system shall be configured with a Microsoft (MS) Windows operating system, featuring a graphical user interface with multiple windows, pull down menus and toolbars. The MS control software shall incorporate an easy install/uninstall wizard. The MS control software shall have the ability to control both the MS and specified HPLC and UPLC devices. -The data processing software shall incorporate an elemental composition calculator. The calculator shall have algorithms for isotope pattern modelling that allow data interpretation of actual isotope patterns. -A "goodness of fit" program from actual to theoretical isotopes shall be included. The ability to filter out incorrect elemental composition calculations through the use of intelligent spectral interpretation algorithms is required. -The software shall offer data directed analysis (DDA); Describes acquisitions whereby the instrument automatically switches into MS/MS mode during an acquisition based upon data acquired in the MS mode in the previous scan. It should be possible to select up to 30 precursors for MS/MS from a Survey scan, with a maximum spectral acquisition rate of 30 MS/MS /sec. If any ion is found above a user-defined threshold in an MS survey scan, the instrument switches to acquire a product ion spectrum for that ion. -DDA acquisition software shall take advantage of ion mobility separations such that; a) an MS/MS spectrum can be acquired at increased sensitivity using the ion mobility enabled Wideband Enhancement mode of operation; or b) where only ions of a given range of characteristic dt (drift time) and m/z values can be selected for MS/MS (for e.g for multiply charged ions). -The software shall offer Multiple Reaction Monitoring (MRM) acquisitions, whereby the instrument automatically switches into MS/MS mode during an acquisition based upon pre-determined criteria such as retention, time, mass-to-charge ratio and drift time (dt). The MRM acquisition software must be able to take advantage of ion mobility separations such that; a) all potential transitions (fragment) from a precursor of interest can be acquired simultaneously at maximum sensitivity using the ion mobility enabled Wideband Enhancement mode of operation; or b) where only ions (transitions) of a given range of characteristic dt can be monitored. -RADAR is the unique ability for quantitative UPLC/MRM acquisition to be performed at the same time as acquiring full scan spectra in positive ion mode and full scan spectra in negative ion mode. This is a valuable tool to help quantitative method development because all ionizable components of the matrix can be easily observed at the same time as the targeted (MRM) analytes of interest. -The software shall be capable of MSE data acquisitions, and alternate between low and high-energy in the collision cell at user-defined intervals. In the low-energy acquisition it records the mass spectrum exhibiting mainly precursor ions, and in the high-energy acquisition their respective fragment ions. -The software shall offer exact parent ion discovery and exact neutral loss: Describes acquisitions where, at user-defined intervals, the instrument alternates between low and high-energy conditions. In the low-energy acquisition it records the mass spectrum exhibiting manly precursor ions, and in the high-energy acquisition their respective fragment ions. In the exact parent ion discovery mode the acquisition system monitors the high-energy data for a specific, diagnostic product ion. Upon detection of the specified product ion the instrument should switch into MS/MS mode and cycle through all possible precursors, present in the low-energy data, to reveal the true precursor. In the exact neutral loss experiment the acquisition system will calculate the masses of all potential precursors in the low-energy data, before interrogating the high-energy data for neutral losses of a specified m/z difference from those calculated masses. Upon detection of the neutral loss the instrument will switch into the MS/MS mode on the suspected precursor ion to confirm its status. -The software should provide a quantitation package as standard which provides quantification of LCMS data. It should quickly process groups of samples, providing automated peak detection, calibration and quantification. Software designed to facilitate the visualization and manipulation of multi-dimensional should be included as standard with the instrument. -The software should permit navigation through a mobility data file displaying information associated with retention time, mass, intensity and drift time. The software should provide the ability to perform peak detection for 3D (m/z, intensity and drift time) or 4D (m/z, intensity, drift time and retention time) datasets. The software shall provide the ability to select detect peaks, to export detected components as a peak list or provide the ability to directly launch elemental composition determination software and structural determination (Mass-fragment) software for subsequent spectral interpretation. The software shall provide the ability to manually generate an ion mobility calibration profile for a range of components of known collision cross-section which will subsequently enable the facile generation of collision cross section values for analytes under identical experimental (ion mobility separation) conditions. The software shall enable the generation of theoretical collision cross section values from one or more pdb (protein databank) files containing the three-dimensional structure coordinates for a sample(s) of interest to facilitate comparison with T-wave derived collision cross section values. -The software shall provide an automated route to calibrating the ion mobility dimension to enable the generation of accurate collision cross section (CCS) measurements in positive or negative ion mode, for routine LC/MS and LC/MS/MS analysis. The software shall also include the ability to use the collision cross section of a reference compound (Lock CCS) at regular intervals to ensure accurate CCS measurement with high precision, irrespective of chromatographic gradient length or the number of samples being analyzed. Instrument Control and Data Processing Units -An embedded PC acquisition system (EPCAS) must be incorporated to the chassis of the instrument to allow data acquisition and dynamic instrument control. The MS software must incorporate wizards that aid the user to set up the operation of the instrument. Functionality must include auto-calibration, and set up of the reference mass for exact mass measurement over the widest available dynamic range. The wizard functionality must provide dialog to keep the user updated on progress throughout the procedure. This software must also facilitate automated LC/MS system check experiments. -A fully synchronized real time data display within a window on the monitor must be provided for ion beam and instrument display. The following type of spectral data must be acquired on the instrument: i.Continuum (profile) data ii.Centroid (stick) data -The instrument must have the ability to switch polarity between experiments, and select appropriate calibration, on a sample list. -The software shall monitor parameters including temperature, voltage and gas flow read backs, calibration validity and available hard disk space and provide a continuously updated indication that the system is functioning correctly. The software shall provide for the automatic testing of the LC/MS system using a sequence of preconfigured LC/MS acquisitions. Ancillary Specifications -The instrument shall be a floor-standing in design, having a footprint no larger than 1500 mm x 720 mm x 1530 mm (H x W x D). The overall weight of the instrument should not exceed 600 kg. A waste solvent drainage system must be integrated into the main chassis of the instrument to allow safe drainage of LC solvent from the source in the event of a nitrogen supply failure to the instrument. A connection must be made to the rear of the instrument for draining solvent safely to a suitable reservoir. Automated, integral fluidics should be present that facilitates seamless instrument calibration, lock-mass introduction and sample introduction into the source. Shipping FOB Destination shall be included in the overall price. The Veteran's Health Administration Service Area Office - East estimates a posting date of solicitation VA240-14-R-0087 on August 20, 2014 and distributed solely through the Federal Business Opportunities (FBO) Website (www.fedbizopps.gov). This notice does not constitute a Request for Proposal (RFP) and should not be construed to as a commitment of any kind by the Government to issue a formal solicitation or ultimately award a contract. Responses to this notice are not offers and cannot be accepted by the Government to form a binding contract. Any costs incurred by interested parties will NOT be reimbursed. It is the responsibility of any interested party to monitor this site for additional information pertaining to this notice. Agency is contemplating single award of a firm fixed price (FFP) contract to the contractor whose submission represents best value to the Government. The North American Industry Classification System code is 334516 Analytical Laboratory and Instrument Manufacturing) with a small business size standard of 500 employees. Interested parties shall be registered in the System for Award Management at (www.sam.gov). Contracting Office Address: 323 North Shore Dr. Pittsburgh PA, 15212 United States Primary Point of Contact: Michael Haydo Contracting Officer Email: michael.haydo@va.gov Phone: 412-822-3158
 

Web Link

FBO.gov Permalink
(https://www.fbo.gov/notices/4e293cbd1b911a964919aca27822c5b5)
 

Document(s)

Attachment
 

File Name: VA240-14-R-0087 VA240-14-R-0087_1.docx (https://www.vendorportal.ecms.va.gov/FBODocumentServer/DocumentServer.aspx?DocumentId=1583876&FileName=VA240-14-R-0087-000.docx)

Link: https://www.vendorportal.ecms.va.gov/FBODocumentServer/DocumentServer.aspx?DocumentId=1583876&FileName=VA240-14-R-0087-000.docx

 

Note: If links are broken, refer to Point of Contact above or contact the FBO Help Desk at 877-472-3779.
 

Place of Performance

Address: Louisville VAMC;Louisville

Zip Code: 40206
 

Record

SN03473927-W 20140822/140821001312-4e293cbd1b911a964919aca27822c5b5 (fbodaily.com)
 

Source

FedBizOpps Link to This Notice
(may not be valid after Archive Date)

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