SOLICITATION NOTICE
R -- Cloning and Purification of IDH1/IDH2 Mutants
- Notice Date
- 8/28/2014
- Notice Type
- Presolicitation
- NAICS
- 541380
— Testing Laboratories
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-PSOL-FY14-665
- Archive Date
- 9/27/2014
- Point of Contact
- Shaun C. Miles, Phone: 3014515042
- E-Mail Address
-
shaun.miles@nih.gov
(shaun.miles@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- INTRODUCTION THIS IS A PRE-SOLICITATION NOTICE OF A PROPOSED CONTRACT TO ACTION. The National Institute on Drug Abuse (NIDA), Station Support Contracts and Simplified Acquisitions Branch (SS/SA) on behalf of the National Center for Advancing Translational Sciences (NCATS) intends to award a contract for the services to clone and purify of IDH1/IDH2 mutants EXTENT OF COMPETITION This acquisition is full and open with no set-aside restrictions. NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE 541380 - Testing Laboratories - and the associated small business size standard is $15.0 Million. REGULATORY AUTHORITY The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular 05-76 dated August 25, 2014 This acquisition is conducted under the procedures as prescribed in FAR Part 13-Simplified Acquisition Procedures at an amount not exceeding the simplified acquisition threshold ($150,000). DESCRIPTION OF REQUIREMENT The contractor shall provide all of the required continued services to obtain bioactivity data from previously ordered protein production. These assays are critical in prioritizing NCATS' medicinal chemistry efforts and to characterize the small molecules that have been generated. NCATS is in need of wild type protein and these two important mutant proteins to study the selectivity and better understand how NCATS' small molecules interact with these mutants most frequently found in some cancers. BACKGROUND The mission of the National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) is to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions. PURPOSE NCATS is in need of three separate services to advance its IDH1 program. NCATS plans to acquire IDH1 WT, IDH1 R132, IDH1 G97D proteins (2 mg of WT and G97D and 5 mg R132C), surface plasmon resonance (SPR) on IDH1 R132C for up to 10 IDH1 inhibitors, and differential hydrogen/deuterium exchange for up to 2 compounds. PERIOD OF PERFORMANCE The anticipated period of performance for this requirement is five (5) months. A firm-fixed price contract is contemplated. PROJECT DESCRIPTION This is a follow on requirement for NCATS. Within nine (9) months after receipt of order, the contractor shall provide all of the following services: • Production and delivery 2 mg of IDH1 WT, and IDH1 G97D and 5 mg IDH1 R132C • SRP of IDH1 R132C for up to 10 IDH1 inhibitors to ascertain full binding characterization of up to 10 ligands via Surface Plasmon Resonance (SPR) experiments • Differential hydrogen/deuterium exchange for up to 2 compounds to identify conformational changes in the protein using HDX mass spectrometry CLOSING STATEMENT The solicitation will be issued on or about September 12, 2014, and quotes will be tentatively due about 5 days after the solicitation release date. Potential offerors may request a copy of the solicitation from the Shaun Miles electronically at shaun.miles@nih.gov. Please reference the solicitation HHS-NIH-NIDA-SSSA-PSOL-FY14-665 on your electronic request.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/HHS-NIH-NIDA-SSSA-PSOL-FY14-665/listing.html)
- Place of Performance
- Address: Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN03485618-W 20140830/140829022544-727b5d686026a3536c0874d397d61cd4 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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