SOLICITATION NOTICE
70 -- Hosting of UDPics, RURO and Phenotips Applications - ISSO
- Notice Date
- 9/17/2014
- Notice Type
- Presolicitation
- NAICS
- 541511
— Custom Computer Programming Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NIH-HHS-NHLBI-CSB-(HG)-2014-243-DLM
- Archive Date
- 10/9/2014
- Point of Contact
- Dorothy Maxwell, Phone: 301-435-0352
- E-Mail Address
-
maxwelld@mail.nih.gov
(maxwelld@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- 508 Information Security THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A CONTRACT WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR A PROPOSAL. A SOLICITATION DOCUMENT WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. INTRODUCTION: The National Institute of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) Office of Acquisition (OA) on behalf of the National Human Genome Research Institute, (NHGRI), intends to negotiate and award a purchase order on a noncompetitive sole source basis to Appistry Inc., 1141 South 7th Street, Suite 300, St. Louis, MO 63104 to procure the following: Follow-On Requirement: SEE ATTACHMENT A AND B FOR ISSO AND 508: Procurement: A. Hosting of UDPics, RURO and Phenotips Applications: 1. Hardware monitoring and maintenance of Hosted Applications; 2. OS and application patching and updates; 3. Maintaining 99.9% ("three nines") system availability (8.76 hours downtime annually); and 4. General system support. B. Setup and compliance of Hosting Environment: 1. Build and configure infrastructure within Appistry's data center to host the UDPics applications, including up to 11 server instances. 2. Migrate existing RURO and Phenotips applications and configurations to Appistry infrastructure. Appistry does not provide licenses for these applications or any other 3rd party applications. BACKGROUND : The National Institutes of Health (NIH) is the nation's leading medical research agency and the primary Federal agency conducting and supporting medical discoveries that improve people's health and save lives. The National Human Genome Research Institute (NHGRI), National Institutes of Health Undiagnosed Disease Program (UDP) is a pilot program designed to address the needs of persons with debilitating medical conditions for which no diagnosis has been found despite an extensive workup. The goals of the UDP include finding accurate diagnoses and discovering new diseases that provide insight into human physiology and genetics. The multi-user nature of NIH's UDP Translational Laboratory, along with its dynamic process structures, engenders a deep set of requirements for any candidate data and project management system. The enterprise-grade LIMS 24/7 platform is a web-based system that encompasses project, task and asset management; user role configurability; user-tailored reporting; extensive audit functionality and information security. LIMS 24/7 is designed to be the meeting place of laboratory software tools, laboratory hardware, and staff users, allowing previously impossible levels of secure data access, communication and process efficiency. Reliability of the LIMs 24/7 platform, UDPICs, and associated software are an integral part of NIH UDP organizational structure. Constant maintenance, including system upgrades, OS and application upgrades, is required for the function of the NIH UDP and likely the extramural Common Fund funded UDN sites. OBJECTIVES: The purpose of this acquisition is to obtain a hosting environment that can provide guaranteed downtime of less than.1% annually (8.76 hours) and the appropriate back up for near instant restoration. Appropriate instant restoration is defined as 99.9% with the following conditions: 1. Any full outages shall be restored within a two hour time frame (total annual downtime must not exceed 99.9% SLA). This does not include isolated failures due to cached DNS beyond Appistry's control. 2. Upon restoration of service, the failover site may be missing up to 48 hours of the most recently inputted data. This includes data that had not yet replicated across sites in the period leading up to the failure as well as rolling back to a known restoration check point when date integrity issues may be implicated in the outage. 3. All recoverable data shall be restored to the failover site within 24 hours of service recovery with the following caveats: a. Corrupt data that requires development, NIH or 3rd party (Ruro, Cartagenia, Phenotips) intervention for recovery may involve longer restoration times b. Data that requires forensic techniques for recovery, such as in the case of a significant physical or environmental disaster, may involve longer restoration times c. Data that requires manual re-entry when no physical media recovery is possible may involve longer restoration times. 4. The contractor must be able to set up a hosting environment to meet the existing and expanding needs of the NIH UDP and establish appropriate FISMA compliance. The contractor must host UDPICS, RURO and Phenotips applications. 5. The contractor must be able to host the NIH Undiagnosed Diseases Program's Laboratory Information Management System called Uniagnosed Diseases Program Integrated Collaboration System (UDPICS). It is designed by RURO, Inc.. This system tracks laboratory samples, data and process management and communication via Chat as well as sharable Electronic Laboratory Notebooks. This current UDPICs system is integrated with and provides permissions for access to other necessary linked applications such as Phenotips, ezColony, and Cartagenia BENCH NGS. This system is used by the intramural clinical and research teams as well as extramural collaborators predicted to number more than 400 in the next 6 months. 6. The Contractor must be able to provide hosting for a multi-user nature of NIH's UDP Translational Laboratory, along with its dynamic process structures, engenders a deep set of requirements for any candidate data and project management system. The enterprise-grade LIMS 24/7 platform is a web-based system that encompasses project, task and asset management; user role configurability; user-tailored reporting; extensive audit functionality and information security. LIMS 24/7 is designed to be the meeting place of laboratory software tools, laboratory hardware, and staff users, allowing previously impossible levels of secure data access, communication and process efficiency. Reliability of the LIMs 24/7 platform, UDPICs, and associated software are an integral part of NIH UDP organizational structure. Constant maintenance, including system upgrades, OS and application upgrades, is required for the function of the NIH UDP and likely the extramural Common Fund funded UDN sites. 7. Consequently, this expansion and extensive international use removes all nights, weekends, and holidays for acceptable downtime and requires a high reliability. Additionally, the intramural UDP has an obligation to provide its inventions as tools for the Common Fund Undiagnosed Diseases Network (UDN) and the hosting contractor must provide the ability for rapid cloning of UDPICS for extramural Common Fund funded sites. Period of Performance : Three Years Upon Award JUSTIFICATION : Appistry is uniquely qualified because 1) Appistry has implemented and hosts the NIH UDP next generation sequencing alignment, genotyping and annotation pipelines (HHSN268201400152P, HHSN26820140024C, and HHSN26820140020C; 2) Appistry operations currently support all the components of UDPICS including solutions from Ruro, Phenotips, and Cartagenia; 3) Appistry has implemented a demonstration version of UDPICS and thereby shown its ability to integrate all these components; 4) Appistry has successfully debut the demonstration version of UDPICS multiple times to members of the Undiagnosed Diseases Network; and 5) Appistry is well along in the process of gaining FISMA certification for hosting of the production version of UDPICS. Specifically, Appistry integrated Ayrris and LIMs24/7 to allow the laboratory to turn workflows into a continuous pipeline that has made collecting, storing, managing, and routing data simple, reliable, and efficient. Integrating the LIMS with a robust big-data environment has enabled the UDP laboratory to establish and maintain a full chain of custody for samples and associated data across the experimental life cycle, standardize physical and digital processes to achieve compliance with regulations such as CLIA, HIPAA or Safe Harbor, and create production-grade workflows necessary for running defined lab workflows at scale. Additionally, Appistry has executed the NIH UDP Diploid-Alignment Pipeline on Ayrris and integrated it with the Ruro LIMS 24/7. Appistry has successfully tested running the Diploid-Alignment Pipeline on Ayrris in Appistry's St. Louis datacenter with execution times taking approximately 26 hours on 100 CPU-cores. This pipeline consists of two phases with the first phase run per individual, and the second phase run per trio or cohort. The Broad Institute GATK Best Practices are followed where appropriate along with extensive parallel executions of time-intensive steps such as alignment, base quality score recalibration, and variant calling. Appistry has also implemented the pipeline within LIMS24/7 by creating two subject workflows corresponding to the two phases of the pipeline. During their pipeline execution on Ayrris, the respective LIMS24/7 subjects are updated automatically through Ayrris-LIMS24/7 API calls to reflect their movement through the workflows. This enables a LIMS24/7 user to monitor the progress of the pipelines without requiring detailed knowledge of how the pipeline is executing. The current contract will allow the use of Appistry Ayrris to align, genotype, and annotate next generation sequencing short reads from 600 individuals consented to the NIH UDP research protocol. They will be doing this using the NIH UDP Diploid-Alignment pipeline that has been developed in collaboration with the NIH UDP. REGULATORY AUTHORITY: This acquisition is conducted under the authority of 41 U.S.C. 253(c) as set forth in FAR Part 6.302-1, only one responsible source and no other supplies or services will satisfy agency requirements. ADDITIONAL INFORMATION: Industry Classification (NAICS) Code is 541511, Custom Programming Services, small business size standard is $25.5M. The acquisition is being conducted under FAR Part 13, simplified acquisition procedures, therefore the requirements of FAR Part 6 B Competitive Requirements are not applicable (FAR Part 6.001). The resultant Contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 05-76 (August 25, 2014). This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by September 23, 2014 and must reference synopsis number HHS-NIH- NHLBI-CSB-(HG)-2014-243-DLM, may be submitted to the National, Heart, Lung and Blood Institute, Office of Acquisition, COAC Services Branch, 6701 Rockledge Drive, Suite 6149, Bethesda, Maryland 20892-7902, Attention: Dorothy Maxwell. Response may be submitted electronically to maxwelld@mail.nih.gov. Faxes will not be accepted. Responses will only be accepted if dated and signed by an authorized company representative. "All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/NIH-HHS-NHLBI-CSB-(HG)-2014-243-DLM/listing.html)
- Place of Performance
- Address: NIH, United States
- Record
- SN03516610-W 20140919/140918000739-a1efefb59150dfcacdb9655663f44b19 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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