SOURCES SOUGHT
66 -- Quanterix – Simoa HD-1 DX Analyzer for NIA Clinical Core Laboratory to continue with the annual Biorepository – Freezer Farm Q.C. Project, as well as use for Homebrew kits for future assay testing.
- Notice Date
- 3/11/2015
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211 - MSC 9559, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-SSBS-15-181
- Archive Date
- 4/9/2015
- Point of Contact
- Samantha A. Kelly, Phone: 3015941571, Rodney E. Brooks, Phone: 3014020751
- E-Mail Address
-
samantha.kelly2@nih.gov, rodney.brooks@nih.gov
(samantha.kelly2@nih.gov, rodney.brooks@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- SOURCES SOUGHT NOTICE 1.Solicitation Number: HHS-NIH-NIDA-SSSA-SSBS-15 -181 2.Title: Quanterix - Simoa HD-1 DX Analyzer for NIA Clinical Core Laboratory to continue with the annual Biorepository - Freezer Farm Q.C. Project, as well as use for Homebrew kits for future assay testing. 3.Classification Code: 66 4.NAICS Code: 334516 5.Description: This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Background: The annual Freezer Farm Q.C. Project was previously performed by the Luminex 100 IS. The purpose of this project is to pull and test samples periodically to make sure the molecular integrity of proteins in the biospecimens is preserved during storage in the freezers located in the Biorepository - Freezer Farm. Temperature changes can take place infrequently or occur over a period of time that can potentially harm the biospecimens' integrity. The freezer quality control (Q.C.) process was designed to test control pools of human serum and plasma stored in every freezer for analytes that are relatively sensitive to temperature change (e.g., enzymes, cytokines, etc.). This will enable quantitative assessment of the quality of sample storage over time and help maintain the integrity of biospecimens over the course of data collection. Due to issues with the Luminex multiplex insensitivity below the assay curve, inconsistencies with sample reproducibility and inability to move beyond the current platform, it was decided to purchase an analyzer such as the Quanterix - Simoa HD-1 DX. The Simoa offers more stable assays without the use of multiple plates and decreased technical error. It has great potential for other projects such Homebrew kits within NIA and NIH wide. Purpose and Objectives: The purpose of this requirement is to purchase a system like the Quanterix-Simoa HD-1-DX Analyzer that is a fully automated digital immunoassay instrument capable of analyzing samples using single-molecule array technology and delivering ultra-sensitive measurements of proteins of interest over a wide dynamic range and with low C.V.'s. The Freezer Farm Q.C. Project involves analyzing samples that have been kept in ultralow temperatures over time. In order to accurately assay these samples for cytokines, the use of an analyzer that offers efficiency and reproducibility of low C.V.s in needed in order to determine which freezers are keeping the samples at optimal temperatures. This in term will give an overall picture of stability in long-term sample storage. The Homebrew kits will be used to help develop cost-effective ultrasensitive assays by enhancing the laboratory's ability to address specific research applications within NIA. The analyzer is an open research platform, allowing the laboratory to design custom assay protocols and optimize calibration curve fitting for custom assays. This will allow for cutting edge digital immunoassay technology, full automation, and open access tools to maximize efficiency and productivity in ultra-high sensitivity immunoassay-enabled research. Contractor Requirements: Product Code - 100438 Product - Simoa HD-1 DX Analyzer The Simoa HD-1 DX Analyzer, a fully automated digital immunoassay instrument capable of analyzing samples using the proprietary single-molecule array (Simoa) technology and delivering ultra-sensitive measurements of proteins of interest over a wide dynamic range and with low CV's. In addition to the features of the Simoa HD-1 analyzer, it includes an integrated barcode reader and a cooled reagent bay. This includes all hardware and software as well as two reagent racks. The system sought has the following characteristics: • The system has the ability to measure biomarkers (proteins/cytokines/metabolites) in biological samples at concentrations that are a 1,000 fold (femtogram/mL) improvement over current ELISA based methods allowing multiplexing assays of up to 10 low abundance proteins/biomarkers simultaneously. • The system is able to detect biomarkers, proteins and DNA in urine, blood, plasma, serum, stool, cell lysates, CSF and environmental water. It also has the ability to measure DNA in an automated fashion with little purification and no amplification. • The instrument is capable of analyzing biological samples using single-molecule digital ELISA array technology; assay technology is not plate-based. Utilizes magnetic beads to form immunocomplex's which allows the enzyme bound to the capture antibody to produce sufficient fluorescence in each well to be detectable, even when just a single molecule is present. • The instrument has an increased sensitivity which will allow for less sample to be used for sample processing (sample volumes 10-100 µL). It utilizes discs with twenty four channels used to load, seal, and image the proteins of interest containing approximately 216,000 wells for maximum sensitivity. • The system is an open platform (Homebrew Kit) which will allow for the adoption and development of markers that might be of commercial interest and not currently available. The open platform assay kits allow end users to modify and develop and adapt unique, lab specific biomarkers. • The workflow is totally automated and plates or tubes can be used for sample introduction. There is no need to manually process plates at the bench and then be introduced into a reader which increases technical error. The digital signal allows for greater sensitivity and reproducibility. • The instrument throughput is 68 tests per hour with results between 30 and 60 mins, run in batches or individually, with analytical precision and C.V. of less than 10% and a dynamic range of 4 to 5 logs. Anticipated period of performance: 90 days after receipt of Purchase Order (PO). Other important considerations: DELIVERY OR DELIVERABLES The analyzer should be delivered to: National Institute on Aging Biomedical Research Center (BRC) 251 Bayview Blvd., Suite 100, Room 08B014A Baltimore, MD 21224 In addition: Payment Terms: 30 Days Net. Pricing USD Shipping Terms: FOB Destination for instruments Shipping Terms: FOB Ship Point for all other products Estimated Ship Date for Instruments: 90 Days CONTRACTING OFFICER'S REPRESENTATIVE (COR) The following Contracting Officer's Representative (COR) will represent the Government for the purpose of this contract: • TBD at time of award Capability statement /information sought: Interested organizations must provide clear and convincing documentation of their capability of providing the item(s) specified in this notice. Interested organizations that believe they possess the ability to provide the required items must submit specific documentation of their ability to meet each of the project requirements to the Contract Specialist. Interested organizations must provide their Company Name, DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc.) pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. The information submitted must be must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2" x 11" paper size, with 1" top, bottom, left and right margins, and with single or double spacing. The information submitted must be must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer. Facsimile responses are NOT accepted. The response must be submitted to Samantha Kelly, Contract Specialist and Rodney Brooks, Contract Specialist at e-mail address: samantha.kelly2@nih.gov and rodney.brooks@nih.gov. The response must be received on or before March 25, 2015 at 12:00PM eastern time. "Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-01/HHS-NIH-NIDA-SSSA-SSBS-15-181/listing.html)
- Place of Performance
- Address: National Institute on Aging, Biomedical Research Center (BRC), 251 Bayview Blvd., Suite 100, Room 08B014A, Baltimore, MD 21224, United States
- Zip Code: 21224
- Zip Code: 21224
- Record
- SN03665350-W 20150313/150311235656-01b2b48c2558c65921f54da24e31ffd0 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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