SOLICITATION NOTICE
66 -- Acquisition of a NanoSight LM10 for detection and sizing of circulating particles
- Notice Date
- 5/12/2015
- Notice Type
- Presolicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Bldg 1050, Frederick, Maryland, 21702, United States
- ZIP Code
- 21702
- Solicitation Number
- N02RC52579-57
- Point of Contact
- Reyes Rodriguez, Phone: 240-276-5442, Seena Ninan, Phone: 240-276-5419
- E-Mail Address
-
reyes.rodriguez@nih.gov, ninans@mail.nih.gov
(reyes.rodriguez@nih.gov, ninans@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- National Cancer Institute (NCI), Center for Cancer Research (CCR), Laboratory of Cancer Biology and Genetics (LCBG) plans to procure on a sole source basis a NanoSight LM10 with high sensitivity camera from Malvern Instruments Ltd. 117 Flanders Road, Westborought MA 01581-1042. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1). The North American Industry Classification System code is 334516 and the business size standard is 500 employees. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. The estimated delivery date shall be 4-6 weeks ARO. It has been determined there are no opportunities to acquire green products or services for this procurement. Multiple CCR laboratories have developed complementary interests in measuring circulating nanoparticles for diagnostic, prognostic and mechanistic purposes. The Laboratory of Cancer Biology and Genetics has discovered that CLIC4 circulates in exosomes and is diagnostic for primary and metastatic tumors. The Laboratory of Human Carcinogenesis has discovered that circulating exosomes in colon cancer patients contains microRNA. The Pediatric Oncology Laboratory is studying circulating exosomes in pediatric cancers. The three groups are collaborating on these studies. Essential to the analysis of circulating nanoparticles is the ability to visualize, count and size the particles to distinguish their purity and confirm they are intact and distinct from other vesicles and debris. The NanoSight is the only instrument capable of performing this function. Contractor Requirements must include: • A Nanosight LM10 with high sensitivity camera for the measurement of size of dispersed particles and molecules in solution. • A diode laser beam directed through a prism in order to concentrate the light intensity for the most efficient scattering in the focal plane and minimize background noise within the sample cell (US patent # 7399600), to reduce the lower detection limit compared to other techniques. • Detection range 10nm-2000nm when using the high-sensitivity sCMOS camera, material dependent. • Measureable total sample concentration range 10x6 - 10x10 particles/ml. Optimum concentration range 10x7 - 10x9 particles/ml. This shall allow measurement of even extremely low particle concentration suspensions. • A flow-through chamber that uses a volume as small as 100 µl, accommodating aqueous fluids used to suspend particles for measurements. A metal sample chamber available for organic solvents. Both shall be available with the syringe pump option to provide measurement of a larger sample volume per analysis. • Sample cells incorporating lasers including 405, 488, 532, and 642nm wavelengths. A Peltier element that can precisely control sample temperature over the range 15 - 50°C, either manually set or through the use of automation scripts. • Ability to be used for fluorescence mode measurements. Suitably labelled particles shall be able to be visualized even in the presence of other particle populations and analyzed without interference. • Ability to provide a direct measurement, with no necessary calibration. Because this is an absolute method, no refractive index or density information for particles shall be required to generate size distributions. The high-resolution data shall be obtained without need for modeling or mathematical curve fitting. • Scattering intensity data that provides an independent variable that can qualitatively confirm the derived size distributions. This information shall be plotted on a particle-by-particle basis with the size and count information. • Ability to record Video clips of light-scattering particles that can be reanalyzed if required. Nanoparticle Tracking Analysis (NTA) to allow one to directly visualize the particles being measured. • All particle size, concentration, scatter intensity and diffusion data can be output in a variety of formats including PDF, CSV spreadsheets, and video files. • A twelve (12) month warranty on all parts must be included. • Shipping and installation costs must be included on the quote. The NanoSight range of particle characterization analyzer from Malvern Instruments is the only commercially known available instrument that uses the Nanoparticle Tracking Analysis (NTA) technique and a patented optical design (US patent # 7399600) to size individual particles as small as 10nm based on their diffusion coefficient. This notice is not a request for competitive quotation. However, if any interested party, especially small business believes it can meet the above requirement, it may submit a proposal or quote for the Government to consider. The response and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 11 AM EST, on May 26, 2015. All responses and questions must be in writing and faxed to 240-276-5399 or emailed to Reyes Rodriguez, Contracting Specialist via electronic mail at reyes.rodriguez@nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, contractors must be registered and have valid certification in the Central Contractor Registration (CCR) and the Online Representations and Certifications Applications (ORCA) through sam.gov. Reference: N02RC52579-57 on all correspondence.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/FCRF/N02RC52579-57/listing.html)
- Place of Performance
- Address: TBD, Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN03728469-W 20150514/150512235719-3eda6f1aa836034371360e2b08a8c2db (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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