SOURCES SOUGHT
66 -- Surface Plasmon Resonance Instrument
- Notice Date
- 6/22/2015
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211 - MSC 9559, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-SS-15-481
- Archive Date
- 7/21/2015
- Point of Contact
- Matthew P. Antonini, Phone: 301-402-1678
- E-Mail Address
-
matthew.antonini@nih.gov
(matthew.antonini@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- INTRODUCTION: This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. BACKGROUND: The National Institutes of Health (NIH) is the nation's leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people's health and save lives. The NCGC (NCATS Chemical Genomics Center) is tasked with identifying and developing novel small molecule leads against a wide spectrum of human disease targets, which it accomplishes by screening thousands of small molecules in collaboration with both intra-and extramural researchers. In pursuit of this goal, the Center has a strong internal team of scientists who continually discover novel small molecules for application against a wide range of human diseases - a crucial capability for these sorts of studies is a sensitive, accurate and easy-to-use SPR (surface plasmon resonance) instrument to allow both internal biologists and chemists to detect and measure the binding affinity of NCGC-developed small molecule leads to their respective targets. PURPOSE AND OBJECTIVES: The purpose of this acquisition is to obtain an SPR instrument. This instrument will allow NCGC to measure small molecule:protein binding affinities with considerable sensitivity, enabling NCGC medicinal chemistry campaigns to be partly driven by dissociation rates. This is a capability our center has lacked since its inception, but recent studies in the drug discovery field have shown that Koff compound dissociation rates are perhaps the single-most important characteristic to optimize during med chem campaigns, as they drive duration of inhibition and selectivity, and can even compensate for poor bioavailability. As such, an SPR instruments represents a key tool for our drug discovery teams across the institute, and it will see extremely high use in our laboratory because of this. PROJECT REQUIREMENTS: NCGC is in need of one (1) SPR instrument that meets the following minimum requirements: •Measures small molecule:protein binding affinities with considerable sensitivity. •Comes with multiple injector/flow cell design for high-throughput experiments. •Contains an automated fluidic system to allow for fast kinetic measurements. •Has multiple surface chemistry capability to ensure compatibility with a wide variety of protein targets. •Allows for detection of protein-small molecule interactions, protein-protein kinetics, antibody affinities & epitope mapping, oligosaccharide characterization, nucleic acid (DNA-DNA or DNA-RNA) hybridization, and biomolecule concentration measurements. In addition, the successful offeror shall provide: •Software for data analysis. •Standard 1 year warranty. •On-site installation of the instrument, including two (2) days of onsite training. ANTICIPATED PERIOD OF PERFORMANCE: Delivery shall be within four (4) weeks from award. PLACE OF PERFORMANCE Equipment shall be delivered for inspection and acceptance to: 9800 Medical Center Drive Room 2050 Rockville, Maryland 20850 CAPABILITY STATEMENT / INFORMATION SOUGHT: Respondents must provide clear and convincing documentation of their capability to offer the product specified in this notice. Also, information must be provided in sufficient details of the respondents' (a) staff expertise, including their availability, experience, and formal and other training; (b) current in-house capability and capacity to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and management capability; and (e) examples of prior completed Government contracts, references, and other related information. Respondents must provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HUBZone) pursuant to the applicable NAICS code AND any other information that may be helpful in developing or finalizing the acquisition requirements. Finally, respondents are also encouraged to provide a general overview of the respondent's opinions about the difficulty and/or feasibility of the potential requirement, and any information regarding innovative ideas or concepts that may be applicable. SUBMISSION INSTRUCTIONS: One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2" x 11" paper size, with 1" top, bottom, left and right margins, and with single or double spacing. The information submitted must be must be in an outline format that addresses each element of the "PROJECT REQUIREMENTS" and each element of the "CAPABILITY STATEMENT / INFORMATION SOUGHT" paragraphs above. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses to this notice must be submitted electronically to the Contract Specialist (Facsimile responses are NOT accepted.): Matthew Antonini Contract Specialist NIH/NIDA/SSSA matthew.antonini@nih.gov DISCLAIMER AND IMPORTANT NOTES: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. CONFIDENTIALITY: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-01/HHS-NIH-NIDA-SSSA-SS-15-481/listing.html)
- Place of Performance
- Address: 9800 Medical Center Drive, Room 2050, Rockville, Maryland, 20850, United States
- Zip Code: 20850
- Zip Code: 20850
- Record
- SN03772493-W 20150624/150622235750-1c6d22bd13fee976f2a32732a3047094 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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