SPECIAL NOTICE
A -- Technology Commercialization Opportunity: Rapid Acoustic Lysis for Point-of-Care Diagnostics - Working with Sandia Brochure
- Notice Date
- 7/1/2015
- Notice Type
- Special Notice
- NAICS
- 541711
— Research and Development in Biotechnology
- Contracting Office
- Department of Energy, Sandia Corp. (DOE Contractor), Sandia National Laboratories, PO Box 5800, MS: 0115, Albuquerque, New Mexico, 87185
- ZIP Code
- 87185
- Solicitation Number
- 15_441
- Archive Date
- 9/16/2015
- Point of Contact
- David Wick, Phone: 505-844-2517
- E-Mail Address
-
dvwick@sandia.gov
(dvwick@sandia.gov)
- Small Business Set-Aside
- N/A
- Description
- Working with Sandia Brochure Background Information: Most biosensors in today's market and in R&D require a critical sample preparation procedure prior to analysis of cellar contents such as nucleic acids and proteins. Technology is needed to release the cellular contents in a format compatible with nano/microfluidic and Point-of-Care (POC) devices. Sandia National Laboratories (SNL) has developed a miniature cell lysis system to overcome the limitations of current extraction methods. This system utilizes high-frequency compression waves with a wavelength similar to the size of cells, resulting in more efficient energy transfer. Unlike commercial acoustic transducers, our technology does not generate significant amounts of heat, making it compatible with protein assays. This technology releases viable DNA, RNA, and proteins from human or bacterial cells, without chemicals or additional processing, to enable high-speed sample preparation for clinical point-of-care (POC) medical diagnostics and use with nano/microfluidic devices. The technology is described further in US Patent Applications: •U.S. Patent Application 14/318,364, filed on June 27, 2014 for "Miniature Acoustic Wave Lysis System and Uses Thereof" •U.S. Patent Application 12/872,919, filed on August 31, 2010 for "Microfluidic Device for Acoustic Cell Lysis" Technology Highlights: -No harsh chemicals or purification needed -Generates PCR-ready DNA -Disrupts the cellular membranes of even the most difficult bacteria in seconds -Reusable -Suitable for processing volumes ranging from 1-1000 microLiters Potential Applications: -Same-day pathogen diagnosis -Point of Care (POC) diagnosis -Lysing of resilient cells -Bio-agent identification -Rapid DNA testing Opportunity Description: SNL is seeking partners to further develop and commercialize a a miniature cell lysis system. Cooperative Research and Development Agreements (CRADAs) and Licensing Agreements are available. Sandia invites interested parties to provide a detailed description of relevant background, experience, expertise, and capabilities that could be brought into a collaborative partnership with Sandia. Specific requirements are as follows: Mandatory Requirements: 1) U.S. companies able to enter into a CRADA agreement with Sandia National Laboratories, which requires in-kind contribution in the form of laboratory staff and instrumentation 2) U.S. companies capable of providing a minimum of $200K funds-in 3) Demonstrated experience in bringing products to market Desired Requirements: 1) Demonstrated experience, expertise, and capabilities in the design, development and manufacturing of medical equipment 2) Demonstrated successful partnering and teaming relationships with R&D organizations In addition to evaluating the provided information as outlined above, Sandia will evaluate all responses and select prospective parties with which to engage in further discussions based on the following criteria, pursuant to Sandia's technology transfer mission: 1) How will the respondent deploy the technology for the benefit of the U.S. public good? 2) How will the respondent's deployment of the technology benefit U.S. economic competitiveness? Sandia is a multi-program laboratory operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the United States Department of Energy's National Nuclear Security Administration under Contract DE-AC04-94AL85000. Primary Point of Contact: David V. Wick Licensing Executive Sandia National Laboratories dvwick@sandia.gov Keywords: Biosensor, Cell Lysis
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/DOE/SNL/SN/15_441/listing.html)
- Record
- SN03782443-W 20150703/150701235226-a2691de5d555fda1cfc11c8043cf47b5 (fbodaily.com)
- Source
-
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