SOURCES SOUGHT
R -- Lipid Profiling Services to Inform NCATS Compound Probe Development
- Notice Date
- 7/10/2015
- Notice Type
- Sources Sought
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-SBSS-15-585
- Archive Date
- 8/1/2015
- Point of Contact
- Lauren M. Phelps, Phone: 3015942490
- E-Mail Address
-
lauren.phelps@nih.gov
(lauren.phelps@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Contracting Office Address: Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, MD 20892, UNITED STATES. Introduction: This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources, (2) whether they are small businesses; HUBZone small businesses, service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. Background: The National Center for Advancing Translational Sciences (NCATS) Division of Preclinical Innovation (DPI) Thymine Team has three on-going probe development projects for compounds that inhibit Th17 cell differentiation and restore lipid storage in Neumann-Pick C and Gaucher disease. In common for these three projects is that compounds appear to be regulating cellular lipid homeostasis. It is therefore critical to quantitate the effect of the compounds being developed on the cellular levels of different lipids to better understand the mechanism of action and improve their activity. The Government therefore requires commercial lipid profiling service so that the Government may use commercially identifiable information to inform future NCATS research efforts. Purpose and Objectives for the Procurement: The purpose of this requirement is to acquire commercial contractor services to analyze the cellular lipid profiles pre- and post- NCATS-testing of several compounds being developed for three projects: Th17 differentiation, Neumann-Pick, C and Gaucher diseases. This requirement constitutes a request for commercial cellular lipid profiling to identify commercially identifiable information. Project Requirements: The Contractor shall perform cellular lipid profiling for three NCATS projects as detailed below. Task A: Commercial Lipid Profiling of Cells in a Model of Niemann Picks C Syndrome 1. The Contractor shall determine the lipid profile of cells in a model of Niemann Picks C Syndrome. This commercial profiling service shall be performed on sample cells provided by NCATS. The sample cells will include cell both with and without exposure to experimental drug using. There shall be 10 million cells per sample and 16 samples. Task B: Commercial Lipid Profiling of Cells in a Cholesterol Metabolism Panel A. The Contractor shall determine the lipid profile of cells in a Cholersterol Metabolism Panel and a Cholesterol Ester Panel. Specifically, the contractor shall provide commercial profiling service identifying zymosterol as an integrated marker in the Cholesterol Metabolism panel and identifying cholesterol ester in the Cholesterol Ester Panel. This commercial profiling service shall be performed on sample cells ad tissue provided by NCATS. The sample cells and tissue will include cells both with and without exposure to experimental drug using. There shall be 10 million cells per sample and 16 samples of the Cholesterol Metabolism Panel and 100 mg of tissue per sample and 24 samples for the Cholesterol Ester Panel. Task C: Commercial Lipid Profiling of Cells in a Model of Gauche Syndrome 1. The Contractor shall determine the lipid profile of cells in a model of Niemann Picks C Syndrome. This commercial profiling service shall be performed on sample cells provided by NCATS. The sample cells will include cell both with and without exposure to experimental drug using. There shall be 10 million cells per sample and 12 samples. Government Furnished Property: For each of the three task areas requiring lipid profiling services, the Government shall provide the successful offeror with frozen cell pellets (of between 25 and 100 million cells each) or tissue, in samples both untreated and treated with several compounds being developed at NCATS. The cell pellets will be provided by the Government with supernatant removed from the isolated cell pellet, the pellets shall be washed to ensure residual media is completely removed, and the cell pellets shall be flash-frozen in liquid nitrogen. The cell pellets shall be sent in 2.0 ml round bottom Eppendorf tubes. Anticipated Delivery Requirements/Period of Performance: Delivery of results and a final report shall be made within four (4) weeks following contractor receipt of samples from the Government. The final report, to include a Word document, a Powerpoint presentation and an Excel spreadsheet detailing results, will outline the lipid profiling procedure used, Metabolite Summary and identification of Significantly Altered Biochemicals, profiling results, and an appendix detailing the commercial profiling methods used. This report shall cover all three task areas. Anticipated Contract Type: A firm fixed price purchase order with NET30 invoicing terms is anticipated. Capability Statement: Contractors that believe they possess the ability to provide the required commercial services should submit documentation of their ability to meet each of the project requirements to the Contract Specialist. Contractors must provide their Company Name, DUNS number, Physical Address, and Point of Contact Information. Interested organizations are required to identify their type of business, applicable North American Industry Classification System Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. All capability statements sent in response to this Sources Sought Notice must be submitted electronically (via email) to Lauren Phelps, Contract Specialist, at Lauren.Phelps@nih.gov in MS Word format by or before the closing date of this announcement. All responses must be received by the specified due date and time in order to be considered. Note: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in the response. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After review of the responses received, pre-solicitation and solicitation notices may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. The solicitation release date is pending. The Government intends to negotiate a fixed-price purchase order.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/HHS-NIH-NIDA-SSSA-SBSS-15-585/listing.html)
- Place of Performance
- Address: Rockville, Maryland, 20850, United States
- Zip Code: 20850
- Zip Code: 20850
- Record
- SN03793530-W 20150712/150710235511-bfd6a80503f99555851a0bc49314525f (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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