MODIFICATION
66 -- Microwave Peptide Synthesizer
- Notice Date
- 7/16/2015
- Notice Type
- Modification/Amendment
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-SBSS-15-576
- Archive Date
- 8/1/2015
- Point of Contact
- Lauren M. Phelps, Phone: 3015942490
- E-Mail Address
-
lauren.phelps@nih.gov
(lauren.phelps@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Contracting Office Address: Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, MD 20892, UNITED STATES. Introduction: This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources, (2) whether they are small businesses; HUBZone small businesses, service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. Background: The National Center for Advancing Translational Science (NCATS), part to the National Institutes of Health, works to catalyze innovative methods and technologies that will accelerate bringing diagnostics and therapeutics to patients. The NCATS Therapeutics for Rare and Neglected Diseases (TRND) Section specially focuses on rare and neglected diseases. One of the objectives pertaining to NCATS's mission is exploring various drug-discovery approaches and enhancing drug-like properties of small molecules via design and synthesis. In this effort, the NCATS TRND works to synthesize peptides and modified peptides as potential therapeutics for diseases like microbial infections, cancers etc. Purpose and Objectives for the Procurement: The purpose of this acquisition is to provide the National Center for Advancing Translational Sciences (NCATS) Therapeutics for Rare and Neglected Diseases (TRND) Section with one (1) microwave peptide synthesizer on a brand name or equal basis. Project Requirements: The Contractor shall provide one (1) Biotage Initiator+ Alstra Fully Automated Single-Channel Programmable Microwave Peptide Synthesizer OR ITS EQUAL as well as FOB Destination delivery and one-site application training. The brand name or equal Fully Automated Single-Channel Programmable Microwave Peptide Synthesizer must meet or be equivalent to the following requirements: 1. The microwave synthesizer must be capable of heating up to 100 degrees Celsius. 2. The microwave synthesizer must be capable of running 60 successive reactions if needed. 3. The microwave synthesizer must have an automatic shut-off safety feature in case of failure to establish expected reaction temperature. 4. The microwave synthesizer must have the ability to turn microwave heating on or off for any reaction in program. 5. The microwave synthesizer must be capable of syntheses on a 5 micro mole to 2 mmol scale. 6. The microwave synthesizer must allow valve-less delivery of amino acids and reagents with complete control of reaction conditions including reagent volume, reaction temperature, and time for each individual reaction in a sequence. 7. The microwave synthesizer must offer variable volume dispensing with.5% accuracy within volume ranges.1 - 12 mL. 8. The microwave synthesizer must allow automated rinsing of the sample loop and needle and also require no priming of amino acids or reagents. 9. The microwave synthesizer must offer oscillating mixing without bubbling or magnetic stir bars. 10. The microwave synthesizer must be able to change reagents within an automated synthesis without priming. 11. The microwave synthesizer must offer a one-button cleaning capability via software control. 12. The microwave synthesizer must have a disposable reaction vessel and ready access to reaction vessel to remove analytical samples for reaction monitoring. 13. The microwave synthesizer must offer the ability to pause the instrument during synthesis to permit sample removal. The synthesizer must also allow incorporation of a pause in a synthesis program. 14. The microwave synthesizer must utilize disposable amino acid vessels. 15. The microwave synthesizer must have a modular rack set up. 16. The microwave synthesizer must allow fully automated as well as semi-automated operation. 17. The microwave synthesizer must have a 10 inch touchscreen with drag and drop features. The equipment software must include calculation of reagent and solvent weights and volumes. 18. The microwave synthesizer must not require nitrogen or other inert gas for reagent delivery. 19. The microwave synthesizer must come with a vacuum pump, complete with cables and connectors 20. The microwave synthesizer must come with a one year warranty maintenance package. Additionally, the contractor shall provide a brand name or equal start-up kit and brand name or equal Alstra MAOS kit for the above-detailed brand name or equal equipment. The start-up kit shall include equipment software, including Branches Software Capability which allows assignment of custom methods of operations, as well as the following or equal: 1. One 32 x 30 mL Amino acid rack 2. One 32 x 30 mL Rack cover plate and foil septa 3. One hundred 30 mL Amino acid tubes, 4. Five 185 mL Reagent bottles, glass 5. One R1-4 Reagent bottle cover plate 6. One R5 Reagent bottle cover plate 7. One R1-4 Reagent bottle foil septa 8. One R5 Reagent bottle foil septa 9. System solvent bottles: 1 x 5 L, 1 x 2 L, and 1 x L liter 10. GL45 brown glass bottles 11. One 10 liter waste bottle 12. Ten 5 mL Reactor vial with PTFE frit 13. Ten 10 mL Reactor vial with PTFE frit 14. Ten 30 mL Reactor vial with PTFE frit 15. One Vial tool 16. One 5 mL Reactor vial extension 17. One 10 mL Reactor vial extension 18. One 30 mL Reactor vial extension 19. Twenty 5 mL/ 10 mL Reactor vial caps 20. Ten 30 mL Reactor vial caps 21. Thirty Reactor vial plugs The MAOS Kit or its equal shall contain the following: 1. Vials, caps, crimper, cavity cover, etc to allow MAOS to take place. 2. Microwave vials:0.2-0.5 mL,0.5-2 mL, 2-5 mL (10pcs of each size),10-20 mL-12 pcs 3. Magnetic stir bars:0.2-0.5 mL,0.5-2 mL, 2-5 mL,(10 pcs of each size),10-20 mL-5 pcs 4. Alucap/Septa-50 pcs 5. Crimper-1pcs, 6. Decapper-1pcs 7. Initiator Getting Started Guide 8. Air hose-2meter 9. Waste Tray Insert- 5pcs 10. Supply Connection set-1pcs 11. Air Control Unit- 1pcs 12. Waste tray Cover- 1pcs 13. Waste tray assy-1pcs 14. Screw, MRT M4 x 8-1pcs 15. Vial Adaptor, 10-20 mL ASM (2pcs) 16. Vial collar-4pcs, O-Ring 22.1x1.6-2pcs, 17. Vial Adaptor, 0.2-0.5 mL- 2pcs, O-Ring 22.1x1.6-2pcs Finally, the Contractor shall provide option period pricing for three years of a Priority Service Agreement on a brand name or equal basis. Each service option year shall be separately priced and may or may not be exercised at the Government's discretion. Anticipated Period of Performance: Delivery shall be made within one (1) week following contractor receipt of order. Delivery schedule is of significant importance. The Priority Service Agreement period of performance shall be one year each, consecutive to one another, with the first starting the day after the one year equipment warranty expires. Anticipated Contract Type: A firm fixed price purchase order with NET30 invoicing terms is anticipated. Capability Statement: Contractors that believe they possess the ability to provide the required equipment should submit documentation of their ability to meet each of the project requirements to the Contract Specialist. Contractors must provide their Company Name, DUNS number, Physical Address, and Point of Contact Information. Interested organizations are required to identify their type of business, applicable North American Industry Classification System Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. All capability statements sent in response to this Sources Sought Notice must be submitted electronically (via email) to Lauren Phelps, Contract Specialist, at Lauren.Phelps@nih.gov in MS Word format by or before the closing date of this announcement. All responses must be received by the specified due date and time in order to be considered. Note: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in the response. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After review of the responses received, pre-solicitation and solicitation notices may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. The solicitation release date is pending. The Government intends to negotiate a fixed-price purchase order.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/HHS-NIH-NIDA-SSSA-SBSS-15-576/listing.html)
- Place of Performance
- Address: Rockville, Maryland, 20852, United States
- Zip Code: 20852
- Zip Code: 20852
- Record
- SN03800373-W 20150718/150717000114-20ebc036e092c654ccb939f1621871d9 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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