SOLICITATION NOTICE
66 -- Upgrade of Ion Mobility Mass Spectrometer
- Notice Date
- 8/6/2015
- Notice Type
- Presolicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-NOI-15-472
- Archive Date
- 9/4/2015
- Point of Contact
- Farrin Stanton, , ,
- E-Mail Address
-
farrin.stanton@nih.gov, farrin.stanton@nih.gov
(farrin.stanton@nih.gov, farrin.stanton@nih.gov)
- Small Business Set-Aside
- Total Small Business
- Description
- INTRODUCTION This is a pre-solicitation non-competitive (notice of intent) synopsis to award a contract without providing for full or open competition (including brand-name). THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR PROPOSAL. A SOLICITATION WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Institute on Drug Abuse (NIDA), Consolidated Station Support and Simplified Acquisitions (CSS/SA) Branch intends to negotiate and award a purchase order to Ionwerks, Inc. for a mobility mass spectrometer upgrade without providing for full and open competition (including brand-name). NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE The intended procurement is classified under NAICS code 334516 with a Size Standard of 500 Employees. REGULATORY AUTHORITY The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 05-83 dated July 2, 2015. This acquisition is conducted under the procedures as prescribed in FAR subpart 13.5—Test Program for Certain Commercial Items and FAR subpart 12—Acquisition of Commercial Items at an amount exceeding the simplified acquisition threshold ($150,000) and not exceeding $6.5 million. STATUTORY AUTHORITY This acquisition is conducted under the authority of 41 U.S.C. 253(c) under provisions of the statutory authority of FAR Subpart 6.302- [specify the applicable authority: (1) FAR 6.302-1—Only one responsible source and no other supplies or services will satisfy agency requirements 41 U.S.C. 253(c)(1). DESCRIPTION OF REQUIREMENT Purpose and Objectives The mission of the Intramural Research Program (IRP) of the National Institute on Drug Abuse is to conduct state-of-the-art research on basic mechanisms that underlie drug abuse and addiction, and to develop new methods for the treatment of drug abuse and addiction. Research is supported at the molecular, genetic, cellular, animal, and clinical levels and is conceptually integrated, highly innovative, and focused on major problems in the field. The long-term goal of the research is to better understand the biological and behavioral factors contributing to initiation, maintenance, and elimination of drug abuse and addiction (and associated diseases), and to translate this knowledge into improved strategies for preventing, treating, and reducing the negative consequences for the individual and for society caused by drug abuse and addiction. The Structural Biology Unit (SBU) at the NIDA IRP was established for the purpose of developing new technology and methods to analyze and measure biomolecules (drugs, lipids, peptides, and proteins). A key component of this research to identify biomarkers for long-time drug abuse and other disease models in order to understand the underlying biochemistry mechanism which will enable better medical treatment. Additionally, the tracking and measurement of drugs of abuse in biological matrices such as tissue and blood will allow for better understanding on the mode of operation for drugs of abuse in the body. To accomplish these goals, the SBU uses mass spectrometry specifically, ion mobility, MALDI, and Electrospray mass spectrometry. PURPOSE AND OBJECTIVES: The SBU has been at the forefront for developing a method combining ion mobility and MALDI mass spectrometry. The vendor, Ionwerk’s, developed a novel MALDI-ion mobility (IM) mass spectrometer for NIDA over ten years ago. This instrument has been vital for the SBU to carry out its purpose for developing novel methods for biomolecule analysis. This has resulted in several publications and research firsts. The SBU was the first lab to apply MALDI-IM mass spectrometry for direct tissue analysis of lipid and drug molecules. Furthermore, the SBU was the first to demonstrate the usefulness of MALDI-IM mass spectrometry to analyze complex mixtures of analytes like lipids without the need for prior liquid chromatography, which greatly speeds up data analysis. This method is now routinely applied for lipid and direct tissue analysis by the mass spectrometry community. As our MALDI-IM mass spectrometer has aged, we require upgraded parts to keep it up with the current technology. By upgrading we will save significant funds versus purchasing a new instrument. The vendor will supply parts and software to improve mass resolution, ion mobility resolution, and data analysis software. Project Requirements The National Institute on Drug Abuse (NIDA), SBU requires an upgrade to their MALDI-ion mobility mass spectrometer. The SBU has spent the last decade pioneering the use of MALDI-IM mass spectrometry for direct tissue analysis of lipids and drugs. In order to keep the MALDI-IM mass spectrometer to current standards we require upgrades to improve the mass resolution, the mobility resolution, and the data analysis software. Specifically, NIDA requires the vendor to provide the following: 1. The vendor shall improve mass resolution to over 5,000 at m/z 760 by providing new ion optics and new reflectron grids for the mass spectrometer. This represents an almost a three-fold increase from the current mass resolution of 2,000. 2. The vendor shall improve mobility resolution to over 50 at m/z 760. To accomplish this, the vendor will supply and install a new mobility cell for the instrument. This represents an almost two-fold increase from the current mobility resolution of 30. 3. The vendor shall provide new data analysis software for the MALDI-IM mass spectrometer that will allow for the analysis of larger data sets. This will allow the instrument to be used to analyze larger tissue sections and to acquire 2-D data with wider ranges in both dimensions (mobility X mass range). Delivery time 6 months after receipt of order. CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME) DETERMINATION The determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted. Specifically, Ionwerks, Inc is capable performing both ion mobility and mass analysis of complex samples. The proposed equipment is an upgrade to current equipment at NIDA/IRP. The upgrade includes: new pulsing optics, ion mobility extraction optics which eliminate detector with increased timing resolution and pulse fidelity. This upgrade will greatly improve the mass and ion mobility resolution of the instrument and will reduce analysis time. The intended source is: Ionwerks, Inc 3401 Louisiana St Ste 355 Houston, TX 77002-9551 CLOSING STATEMENT THIS SYNOPSIS IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.” A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by the closing date and time of this announcement and must reference the solicitation number. Responses may be submitted electronically to Farrin Stanton, Contract Specialist, at Farrin.Stanton@nih.gov. US Mail and Fax responses will not be accepted.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/HHS-NIH-NIDA-SSSA-NOI-15-472/listing.html)
- Place of Performance
- Address: 31 Center Drive, Suite 1B59, Bethesda, Maryland, 20879, United States
- Zip Code: 20879
- Zip Code: 20879
- Record
- SN03827406-W 20150808/150806235809-60eb4e61a7deaf03a28f34726e0ad906 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |