SOLICITATION NOTICE
B -- Service contract for 40,000 input genomes, and 200,000 TCR sequences for 600 DNA Extraction service and 600 immunoSEQ hsTCRB service (survey)
- Notice Date
- 9/18/2015
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 541711
— Research and Development in Biotechnology
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E128, Rockville, Maryland, 20852, United States
- ZIP Code
- 20852
- Solicitation Number
- N02RC52702-83
- Archive Date
- 10/9/2015
- Point of Contact
- Gwennifer K. Epps, Phone: 240-276-5445, Terry Galloway, Phone: 240-276-5384
- E-Mail Address
-
eppsg@mail.nih.gov, gallowaytl@mail.nih.gov
(eppsg@mail.nih.gov, gallowaytl@mail.nih.gov)
- Small Business Set-Aside
- Total Small Business
- Description
- Short Title: Service contract for 40,000 input genomes, and 200,000 TCR sequences for 600 DNA Extraction service and 600 immunoSEQ hsTCRB service (survey) Solicitation Number: N02RC52702-83 Proposed Posted Date: September 18, 2015 Proposed Response Date: September 24, 2015 Classification Code: 6505 - Drugs and Biologicals I. Description The National Cancer Institute (NCI), Center for Cancer Research (CCR), Surgery Branch (SB) plans to procure 40,000 input genomes, and 200,000 TCR sequences for 600 DNA Extraction service and 600 immunoSEQ hsTCRB service (survey) to include domestic shipping and handling. This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; quotes are being requested and a written solicitation will not be issued. The combined synopsis/ solicitation number remains the same: N02RC52702-83. This solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (FAC 20) 05-72, (January 2014) Simplified Procedures for a Commercial Item. The Government contemplates only one award of a Firm-Fixed Price contract. The Associated North America Industry Classification Code (NAICS) 541711 and the Business Size Standard is 500. It has been determined there are no opportunities to acquire green products or services for this procurement. Only one award will be made as a result of this solicitation. This will be 100% small business set-aside. The Surgery Branch of the National Cancer Institute has a dual function at the NIH. Investigators in the Branch are involved in the conduct of laboratory and clinical research aimed at improving the care, management, and outcome of patients with cancer. Important areas of laboratory research include tumor immunology, immunotherapy and gene therapy of solid tumors, epigenetic changes in pulmonary malignancies, tumor stem cells, and molecular changes in breast carcinogenesis. In these studies, an emphasis is placed on the translation of laboratory findings into the development of clinical protocols. Clinical efforts emphasize the development of new approaches to the immunotherapy of cancer, to the diagnostic and prognostic evaluation of solid tumors, as well as the development of innovative surgical and adjunctive approaches to the treatment of patients with primary and metastatic cancer. T cells express a T cell receptor (TCR) on the cell surface that determines their specificity. A TCR is created by selecting and splicing together a single V, D and J segment from a collection of available genomic segments. At the junctions between V-D and D-J segments, a varying number of nucleotides are deleted and a special enzyme inserts random nucleotides, creating a unique TCR. It is these inserted nucleotides that are responsible for the vast diversity found in the human TCR repertoire. T cell receptor immune-profiling can be used to monitor T cell responses to a given immune challenge even without the knowledge of the specific epitope targeted. NCI is particularly interested in performing TCR sequencing from T cell populations isolated from human tumor samples. In the tumors, T cells are exposed to tumor antigens, and the frequency of a specific TCR clonotype could be indicative of its ability to recognize the tumor. Thus, the study of the intratumoral T cell repertoire may lead to novel ways to rapidly identify and isolate TCRs that can be used to treat patients with cancer. The technology necessary to sequence the hypervariable region of the TCR involves a multiplex PCR with a mixture of primers targeting the rearranged variable and joining segments to capture receptor diversity. Differential hybridization kinetics can introduce significant amplification biases that alter the composition of sequence libraries and potentially biasing the data obtained. Thus, the purpose of this acquisition is to purchase 40,000 input genomes, and 200,000 TCR sequences for 600 DNA Extractions and 600 immunoSEQ hs TCRB service (survey). Provisions/Clauses Information: This solicitation incorporates one or more solicitation provisions/clauses by reference with the same force and effect as if they were given in full text. Upon request, the CO will make their full text available. II. Delivery Contractor(s) shall deliver the items within 45 days after award to: NIH/NCI Bethesda, Maryland 20892. The Contractor that receives the award will be provided with the complete mailing address and point of contact. Upon delivery, contractor must notify the NCI Contracting Officer's Representative (COR) to schedule the delivery date and time. III. Payment Payment shall be made after delivery, installation, and successful operation of equipment. Payment authorization requires submission and approval of invoice to the NCI COR and NIH Commercial Accounts. BASIS FOR AWARD: Offerors must provide descriptive literature or other materials that demonstrate their offer meets the forgoing requirements. The contract will be awarded to the responsible offeror with the lowest priced technically acceptable (LPTA) offer that fully meets the requirements of the solicitation. QUOTATIONS ARE DUE: September 24, 2015 at 10:00 am, EST. PROVISIONS AND CLAUSES: The following provisions and clauses will be incorporated by reference: 52.212-1 Instruction to Offerors Commercial Items 52.212-2, Evaluation Commercial Items: The purchase order will be awarded to the Lowest Price Technically Acceptable (LPTA). The award will be made on the basis of the lowest evaluated price of quotations meeting or exceeding the acceptability standards for the requirements/technical specifications stated above. The technical evaluation will be a determination based on information furnished by the vendor. The Government is not responsible for locating or securing any information which is not identified in the proposal. The Government reserves the right to make an award without discussions. 52.212-3 Offerors Representations and Certifications Commercial Items (November 2013) WITH DUNS NUMBER ADDENDUM (52.204-6 (July 2013): 52.212-4 Contract Terms and Conditions Commercial Items, applies to this acquisition. 52.212-5 Contract terms and Conditions Required to Implement Statutes or Executive Orders---Commercial Items (January 2014). The following additional FAR clauses cited in this clause are applicable: (b) The Contractor shall comply with the FAR clauses in this paragraph (b) that the Contracting Officer has indicated as being incorporated in this contract by reference to implement provisions of law or Executive orders applicable to acquisitions of commercial items: 52.203-6, Restrictions on Subcontractor Sales to the Government, with Alternate I (41 U.S.C. 253g and 10 U.S.C. 2402) 52.204-10 Reporting Executive Compensation and First Tier Subcontract Awards 52.209-6, Protecting the Government' Interest When Subcontracting with Contractors Debarred, Suspended, or Proposed for Debarment 52.219-4 Notice of Price Evaluation Preference for HUBZone Small Business Concerns 52.219-6 Notice of Total Small Business Set-Aside (NOV 2011) (15 U.S.C. 644) 52.219-8 Utilization of Small Business Concerns 52.219-28 Post Award Small Business Program Representation 52.222-3, Convict Labor 52.222-19 Child Labor Cooperation with Authorities and Remedies 52.222-21 Prohibition of Segregated Facilities 52.222-26 Equal Opportunity 52.222-35 Equal Opportunity for Veterans 52.222-36 Affirmative Action for Workers with Disabilities 52.222-40 Notification of Employee Rights Under the National Labor Relations Act 52.222-37 Employment Reports on Veterans 52.223-18, Encouraging Contractor Policies to Ban Text Messaging while Driving 52.225-1 Buy American Act - Supplies 52.225-13 Restrictions on Certain Foreign Purchase 52.232-33 Payment by Electronic Funds Transfer System for awards Management 52.247-64, Preference for Privately-Owned U.S. Flag Commercial Vessels 52.243-1 Changes - Fixed-Price. (AUG 1987) 52.252-1 Solicitation Provisions Incorporated by Reference. (FEB 1998) 52.252-2 Clauses Incorporated by Reference. (FEB 1998) 52.246-2 Inspection of Supplies-Fixed Price Full text copies of the representations and certifications for other cited provisions and clauses many be obtained on line at the NCI website at http://ncioa.cancer.gov/oa-internet/reference.jsp or from Gwennifer Epps, Contracting Officer at eppsg@mail.nih.gov. Quotations must be received in the NCI-OA Contracting Office by 10:00 a.m. EST,on September 23, 2015. Please refer to the solicitation number: N02RC52702-83 on all correspondence. No collect calls will be accepted. Faxed or electronic mail quotations will NOT be accepted. OFFERORS: Offers must submit a quote/bid in order to receive an award. In order to receive an award, contractor must be registered and have valid certification in the Central Contractor Registration (CCR) and the Online Representation and Certifications Applications (ORCA) through sam.gov.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/RCB/N02RC52702-83/listing.html)
- Place of Performance
- Address: National Cancer Institute, NIH - Clinical Research Center, Bethesda, Maryland, 20814, United States
- Zip Code: 20814
- Zip Code: 20814
- Record
- SN03893082-W 20150920/150918235011-e2e15c3ed4f125984c78b3cadfd8d57a (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |