MODIFICATION
B -- SCREENING FOR CARDIOTOXICITY AND NEUROTOXICITY COMBINED WITH HEPTATOTOXICITY IN ZEBRAFISH - Amendment 1
- Notice Date
- 9/21/2015
- Notice Type
- Modification/Amendment
- NAICS
- 541380
— Testing Laboratories
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, Office of Acquisitions, Office of Management, 530 Davis Drive, Durham, North Carolina, 27713, United States
- ZIP Code
- 27713
- Solicitation Number
- NIHES2015063
- Point of Contact
- Onyenauché Washington, Phone: (919) 541-0423
- E-Mail Address
-
uche.washington@nih.gov
(uche.washington@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Attachment III -Government's Responses to Questions Attachment I, Revised SOW NIHES2015063 Amendment 000001 NIHES2015063 The purpose of this Amendment is (1) to revise Attachment I, Statement of Work; (2) to add Attachment III, The Government's Response to Industry Questions; and (3) to revise the Request for Quote (RFQ) See highlighted texts for changes. The response date of September 21, 2015 remains unchanged.This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 in conjunction with FAR 13, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. (1) This solicitation document, NIHES2015063, is issued as a Request for Quotation (RFQ) to provide screening for cardiotoxicity and neurotoxicity combined with heptatotoxicity in zebrafish for the National Institutes of Environmental Health Sciences (NIEHS), Research Triangle Park, NC. (2) This solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Regulation (FAR); HHS Acquisition Regulation (HHSAR); Federal Acquisition Circular (FAC) 2005-82 effective May 7, 2015. (3) Notice of Set-Aside, Associated NAICS Code, and Size Standard: This solicitation competed on a full and open competitive basis. The associated NAICS code is 541380, "Testing Laboratories" with a size standard of $15.0M. (4) List of Contract Line Item Number(s) and items, quantities and units of measure, (including option(s): See document titled RFQ, NIHES2015063, screening for cardiotoxicity and neurotoxicity combined with heptatotoxicity in zebrafish. (5) Description of Requirements for the Items to be acquired: The National Toxicology Program (NTP) has been interested in exploring effects of toxicants during early developmental life stages since they are often uniquely sensitive to environmental insults, due in part to the enormous changes in cellular differentiation, proliferation and migration required to form the required cell types, tissues and organs. As part of this, there has been recent interest across the NTP in exploring the utility of zebrafish as a potential model to be incorporated into screening efforts since it offers many practical advantages, including rapid external development, ease of maintenance, high fecundity, transparent embryos, and homology to mammals. While there are other ongoing efforts to assess teratogenicity and molecular end-points following early exposure, there are currently no studies in place to assess cardiotoxicity in conjunction with neurobehavior and hepatotoxicity by multiplexing assays in a Good Laboratory Practice (GLP) environment. The Contractor shall have extensive experience conducting studies multiplexing various assays to provide composite information on systemic toxicity. Assays shall be conducted for screening cardiotoxicity, and a combination of behavioral alterations to assess neurotoxicity and hepatotoxicity. These studies will provide valuable information in different target organs, and will be useful in identifying relative toxicity of compounds for further prioritization for in vivo hazard characterization. Early developmental exposure can cause a large spectrum of health impairments affecting various biological systems. Toxicant screening with high throughput in vitro assays can provide important information concerning the immediate effects on cellular function. Intermediate models like zebrafish, are important since they reduce the time and cost required for toxicology testing, thereby increasing the success rate of rapidly identifying potential target organs for environmental toxicants and help with prioritizing which chemicals should be then followed up with studies in mammalian models. This project will serve to demonstrate the usefulness of the zebrafish model for providing key information concerning cardiotoxicity, hepatotoxicity and neurotoxicity following developmental exposures. The Contractor shall reduce the time required to perform mammalian toxicity testing, and shall be able to screen a larger number of compounds more rapidly. The Contractor shall utilize an innovative method in which several assays shall be multiplexed using automation to conduct medium throughput high-content screening in zebrafish. The Contractor shall provide zebrafish based services in the preclinical area, mainly toxicology, as well as safety and efficacy. The Contractor shall assess the impact of exposure during development on cardiotoxicity and neurotoxicity combined with heptatotoxicity of 30 compounds with unknown toxicological potential in zebrafish embryos. (6) Date(s) and place(s) of performance and acceptance and FOB point: A base of 12 months with one (1) 1-year option period. Studies shall be completed within 75 days following receipt of compounds. The opportunities for sample degradation and compromising the quality of data are greater with the continued movement of samples to various sites for analysis, therefore; analysis shall take place in a single facility located within the contiguous United States (CONUS). (7) The provision at FAR 52.212-1, Instructions to Offerors -- Commercial, applies to this acquisition. See document titled RFQ, NIHES2015063, screening for cardiotoxicity and neurotoxicity combined with heptatotoxicity in zebrafish. (8) Applicability of the provision at FAR 52.212-2, Evaluation -- Commercial Items. See document titled RFQ, NIHES2015063, screening for cardiotoxicity and neurotoxicity combined with heptatotoxicity in zebrafish. (9) FAR 52.212-3, applies to this acquisition: Representation, Certifications, and Other Statements of Offerors - In accordance with provisions FAR 52.212-3, Offeror Representations and Certifications--Commercial Items, IF YOU INTEND TO SUBMIT A PROPOSAL, YOU MUST: (1) Go to the Online Representations and Certifications Application (ORCA) and complete the Representations and Certifications. Offerors must access ORCA through the System for Award Management (SAM) at http:// www.sam.gov; and (2). Complete, and INCLUDE as part of your price proposal. (10) FAR 52.212-4 Contract Terms and Conditions Commercial Items, applies to this acquisition. See document titled RFQ, NIHES2015063, screening for cardiotoxicity and neurotoxicity combined with heptatotoxicity in zebrafish. (11) FAR 52.212-5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders--Commercial Items. See document titled RFQ, NIHES2015063, screening for cardiotoxicity and neurotoxicity combined with heptatotoxicity in zebrafish. (12) The Date, Time and Place Offers are Due: The Quoter shall submit dated quote to the following e-mail address: uche.washington@nih.gov at or before Monday, 21 September 2015 at 12:00 PM EST. (13) The point of contact (POC) for this acquisition is Ms. Onyenauche Washington at (919) 541-0423/uche.washington@nih.gov.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIEHS/NIHES2015063/listing.html)
- Place of Performance
- Address: See SOW, United States
- Record
- SN03896695-W 20150923/150922000028-e444e5721efdaf7371cc359d8ab4621c (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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