SOLICITATION NOTICE
66 -- MACSQuant Analyzer 10 System
- Notice Date
- 9/23/2015
- Notice Type
- Presolicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NHLBI-CSB-(HL)-2015-264-JML
- Archive Date
- 10/13/2015
- Point of Contact
- Jonathan M. Lear,
- E-Mail Address
-
learj@nhlbi.nih.gov
(learj@nhlbi.nih.gov)
- Small Business Set-Aside
- Total Small Business
- Description
- INTRODUCTION THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION. The National Heart, Lung, and Blood Institute (NHLBI), Office of Acquisitions (OA), intends to negotiate and award a purchase order on a noncompetitive sole source basis to Miltenyi Biotec, Inc., 2303 Lindberg Street, Auburn, CA 95602-9562 to provide the MACSQuant Analyzer 10 to the NHLBI Division of Intramural Research (DIR) in accordance with the following information. BACKGROUND In order to further the institutional mission, the laboratories within the Center for Molecular Medicine (CMM) and the 5 East Laboratory area are actively taking advantage of new technologies that allow the lab to clarify metabolic processes in both patient samples and multiple mouse strains that query the interface between metabolism, aging, and cancer. The studies performed in the Center for Molecular Medicine focus on the concept that many diseases have at their root a small number of molecular mechanisms, which if properly understood, could be efficiently targeted with appropriate therapeutics. Researchers in CMM study diseases ranging from atherosclerosis, aging, metabolism, and neurodegeneration by conducting biomedical research directed at defining molecular mechanisms underlying human disease, developing a range of animal and cell based models of human diseases, and implementing mechanism-driven clinical studies designed to provide insight regarding underlying disease mechanisms or test proof-of principle therapeutic approaches. Having access to Miltenyi Biotech's MACSQuant Analyzer 10 system will increase the productivity and efficiency of many studies being performed within the 5 East Laboratory area and CMM. The Miltenyi Biotech MACSQuant Analyzer 10 system will support many ongoing animal and clinical study protocols within CMM and the 5 East Laboratory area. For example, the MBS group within CMM has an ongoing study that has been performing a very comprehensive study of mitochondrial function using numerous mouse models. Other groups will need to expand their work using the Guava system, where they study the effects of numerous proteins on mitochondrial biology and metabolism in various organ systems and assess mitochondrial function in hepatic, hematopoietic, cardiac, and neuronal cells. The system will also be used for investigating the genetic mechanisms of cardiovascular diseases and cancer, murine arterial wire injury as a model of vascular remodeling, murine model of vein grafting, and stem cell transplantation in a murine hind limb model. These studies attempt to trace adaptive immune cells to determine their function in vivo and characterize some specific cell markers both in teratomas and after vascular remodeling. In addition, the system will support clinical work under the "Cardiovascular Disease Discovery Protocol". This study intends to characterize and compare patient-specific IPS and IPS-derived cell lines to the corresponding primary human cells. The primary and IPS/IPS-derived cell lines will also be used for in vitro disease modeling. Some of these cells require further differentiation and the lab needs to perform FACs analysis to look for phenotypic cell-type specific marker expression and changes in cell-type specific markers over time. PURPOSE The proposed unit is required so that the lab can continue performing studies in a timely fashion and without interruptions. The Miltenyi system represents an efficient use and sharing of government resources and will give researchers a cutting edge advantage due to its advanced and unique technology. CONTRACTOR REQUIREMENTS The contractor shall provide the following: -MACSQuant Analyzer 10 (Qty. 1) -MACS MiniSampler for Automated Processing of Multiple Samples (Qty. 1) -MACS Chill 5 Rack (Qty. 1) -MACS Cooling Rack - Chill 96 (Qty. 1) -MACSQuant Analyzer Training (for one (1) user) DELIVERY DATE The delivery date shall be thirty (30) days after receipt of the award. JUSTIFICATION The sole source determination is based on the fact that Miltenyi Biotec is the sole manufacturer and provider of the MACSQuant Analyzer 10. No third parties are authorized to resell this equipment. Replacement parts and maintenance must also be provided by Miltenyi Biotec. It is essential to the lab's operations that it acquires this particular analyzer for the following reasons: The first essential feature of the analyzer is its automated start-up, shutdown, and cleaning programs; these assure that the system is kept in optimal analysis conditions. Since the unit is intended to be a common piece of equipment, it is important to have these types of controls in place so as to prevent user-dependent errors and damage. Miltenyi also provides on-instrument remote diagnostics and application support at extended hours during the week, so they can support the system immediately if there is a technical question or issue. The second essential feature is the photomultiplier tubes to enhance detection in both the Forward Scatter and Sider Scatter Detectors. This effectively enhances the detection process for detection or rare cell events. The system has three air-cooled, spatially separated lasers, which effectively improves the analysis. The unit has ten (10) optical detection channels (eight (8) fluorescent and two (2) scatter) and it uses photomultiplier tubes for all eight (8) fluorescent detectors. This is essential for the lab since rare cell populations are routinely analyzed and need to make sure the system is sensitive enough to capture these rare events. Another essential feature is that the MACSQuant Analyzer 10 uses hydrodynamic focusing as part of its fluidics system and a robotic uptake port that allows for automated sample processing and washing. Since this is shared piece of equipment, this feature will assure potential problems and down time for the system are minimized. The MACSQuant Analyzer 10 also has an automated pipette action mixing, which is more efficient and reliable than other mixing systems in the market. Most importantly, this unit has the smallest inter-sample carry-over on the market - only 0.1% between samples. This is an important feature for the lab since it will assure the integrity and reliability of the data. In addition, this unit can analyze a wide range of sample volumes starting as low as 25uL. It can acquire up to 10,000 events per second, which is an essential feature for the analysis of rare cells. The lab needs to analyze millions of cells per sample in order to identify rare cell populations and the speed of analysis of the Miltenyi unit will assure that the analysis can be performed fast and in a way that will maintain and safeguard the viability of the samples. Patient samples are analyzed, so the lab cannot afford to lose them due to slow assay time. Another feature that makes this system ideally suited for the laboratory is that it offers enrichment columns that allow the detection of rare cells which are below the detection threshold of all other flow cytometers in the market. It also has an integrated liquid handling system for automated sample labeling, mixing, and processing that offers absolute volumetric cell counting. This unit also offers an integrated PC with touch screen interface, which makes the system more compact and space efficient. This feature is not available in any other instrument and is essential to the lab. REGULATORY AUTHORITY This acquisition is conducted under the authority of the Federal Acquisition Regulations (FAR) Subpart 13.106-1(b) Soliciting from a single source (for purchases not exceeding the simplified acquisition threshold) and only one responsible source and no other supplies or services will satisfy agency requirements. ADDITIONAL INFORMATION The North American Industry Classification System (NAICS) Code is 334516, Analytical Laboratory Instrument Manufacturing, and the Small Business Size Standard is 500. This acquisition is being conducted under FAR Part 13, Simplified Acquisition Procedures, therefore the requirements of FAR Part 6, Competitive Requirements, are not applicable and the resultant award will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 05-84 (September 3, 2015). This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by September 28, 2015 at 12:00pm EST and must reference synopsis number NHLBI-CSB-(HL)-2015-264-JML. Responses shall be submitted to the National Heart, Lung, and Blood Institute, Office of Acquisitions, COAC Services Branch, 6701 Rockledge Drive, Room 6151, Bethesda, Maryland 20892-7902, Attention: Jonathan M. Lear. Responses may be submitted electronically to john.lear@nih.gov. Faxes will not be accepted. Responses will only be accepted if dated and signed by an authorized company representative. "All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/NHLBI-CSB-(HL)-2015-264-JML/listing.html)
- Place of Performance
- Address: National Institutes of Health / NHLBI, Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN03899650-W 20150925/150923235224-1d01854d86397e9a79c625766438e586 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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