SOURCES SOUGHT
A -- Structural Genomics Centers for Infectious Diseases
- Notice Date
- 10/29/2015
- Notice Type
- Sources Sought
- NAICS
- 541711
— Research and Development in Biotechnology
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Office of Acquisitions, 5601 Fishers Lane, 3rd Floor, MSC 9821, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIAID-SBSS-16-NIHAI2016061
- Point of Contact
- Swee L. Teo, Phone: 240-669-5173, George Kennedy, Phone: 240-669-5170
- E-Mail Address
-
teosl@niaid.nih.gov, kennedyg@mail.nih.gov
(teosl@niaid.nih.gov, kennedyg@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Introduction This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. Background The National Institute of Allergy and Infectious Diseases (NIAID) has made a significant investment in genomic-related programs and activities that provide comprehensive genomic, functional genomic, bioinformatics, proteomic, and systems biology resources to the scientific community for basic and applied research to rapidly address the Institute's mission and the Nation's biodefense needs ( http://www.niaid.nih.gov/topics/pathogengenomics/pages/relatedinitiatives.aspx ). These genomics programs and activities have not only provided the scientific community with valuable research resources, but have also enhanced the NIAID's research efforts in a number of areas including pathogen identification, investigation of pathogen virulence mechanisms, and drug and diagnostics development. Projects within these programs have utilized high-throughput (HTP) technologies to investigate the genome, transcriptome, proteome, or metabolome of a living organism, either as independent entities or as highly interrelated and interdependent components of biological systems. Purpose and Objectives To build upon the objectives of the NIAID Genomics programs and continue to address the Institute's need to further expand the knowledge of the proteome of microbes and the understanding of functional roles of proteins in biological systems, and to support structure-guided design and discovery of new vaccines and therapeutics against infectious diseases, NIAID is re-competing the Structural Genomics Centers for Infectious Diseases program, herein referred to as the SGCID program. In 2007, the NIAID established two five-year contracts to support the SGCID program. These SGCID centers focused on determining three-dimensional (3D) structures of protein targets of biomedical interest. The targets' 3D structure information, as well as the expression clones and peptide materials for thousands of protein targets are made available to the scientific community. The SGCID program was re-competed in 2012 and two five-year contracts were awarded to: ( http://www.niaid.nih.gov/labsandresources/resources/dmid/sg/Pages/default.aspx ): 1. SSGCID: Seattle Structural Genomics Center for Infectious Diseases (Contract No. HHSN272201200025C) 2. CSGID: Center for Structural Genomics for Infectious Diseases (Contract No. HHSN272201200026C) The goal of the SGCID program is to continue the experimental determination of 3D atomic structures of proteins and other molecules with an important biological role in human pathogens themselves, or molecules involved in host-pathogen interactions, by applying state-of-the art HTP technologies and methodologies. Pathogens include those included on the NIAID Category A-C Priority Pathogen lists and organisms causing emerging and re-emerging infectious diseases ( http://www.niaid.nih.gov/topics/BiodefenseRelated/Biodefense/research/Pages/CatA.aspx ). This program will also support research projects that utilize experimental approaches to better characterize the molecular mechanisms of protein targets and gain further insight into the functional roles of these targets. The knowledge of the 3D structures and molecular functions of protein targets will provide: 1) a structural view of biological processes and pathways to assist investigation at the systems level; and 2) insights into the target functional mechanisms, in interaction with other biological molecules or with synthetic compounds. In addition, this program will support projects that perform structure-guided vaccine design and drug discovery and conduct evaluation and validation of the underlying mechanism of action required for therapeutic use against infectious diseases. The structure-guided approach will provide improved selectivity, specificity and optimization of drug and vaccine identification and development in a rational way. The 3D structure information, reagents including expression clones and purified proteins, and services provided by the SGCID centers will be made freely available to the broad scientific community. Project Requirements The purpose of this anticipated solicitation is for scientific support of the SGCID program through a) generation of 3D structures for targets derived from bacterial, viral, eukaryotic and other human pathogens using HTP technologies and methodologies; b) conduct of studies to characterize molecular functions and biochemical properties of selected targets; c) conduct of studies for structure-guided design and functional evaluation of drug targets and vaccine candidates; d) provision of a 3D structure determination service to the external scientific community; and e) dissemination of contract generated resources, including all 3D structure information and reagents. Anticipated Period of Performance It is anticipated that one or more cost reimbursement, level of effort type contracts will be awarded with a one-year base period of performance beginning on or around June 1, 2017. Awards are expected to include 4 one-year option periods. The Government's base level of effort requirement is estimated at 35,360 labor hours for each contract year, equating to 17 FTE's with an FTE being defined as 2,080 hours. In addition to the base level of effort, each year of performance is anticipated to contain an option quantity for up to 6 additional FTEs. Capability Statement / Information Sought Sources are expected to have the expertise, personnel, and facilities to meet requirements of this project. Tailored Capability Statements submitted as a result of this announcement should demonstrate the offerors' qualifications and experience, specifically providing evidence as to their capability to perform this requirement, with particular attention to the following technical areas: 1. The ability to establish and maintain a SGCID program that applies state-of-the art HTP technologies and methodologies to experimentally characterize the 3D atomic structure of proteins or other molecules having an important biological role belonging to human pathogens, include those in the NIAID Category A-C Priority Pathogen lists and organisms causing emerging and re-emerging infectious diseases ( http://www.niaid.nih.gov/topics/BiodefenseRelated/Biodefense/research/Pages/CatA.aspx ). 2. The ability to establish and implement projects aimed at characterizing the molecular functional role and biochemical properties of targets whose 3D structure was determined by the incumbent NIAID Structural Genomics Centers for Infectious Diseases. 3. The ability to establish and implement projects aimed at performing structure-guided vaccine design and drug discovery, and evaluation and validation of the underlying mechanism of action required for therapeutic use against infectious diseases. 4. The ability to establish data management system, computational infrastructure and bioinformatics capability to support data management and analysis, algorithm and software application development, and other computational approaches for assisting target selection and in silico screening for structure-guided vaccine design and drug discovery. 5. The ability to provide structure determination services to the external scientific community and to establish processes to engage external investigators for collecting recommendations for targets for structure determination. 6. The ability to ensure that all contract-generated resources are publicly available and easily accessible to the scientific community. 7. The ability to establish a multi-disciplinary team with adequate scientific and technical personnel according to the estimated number of labor hours per contract year. 8. The ability to provide a technical and administrative management infrastructure to ensure the efficient planning, implementation, oversight, and completion of all required activities. How to Submit a Response: Page Limitations Interested qualified small business organizations should submit a tailored Capability Statement not to exceed five pages, excluding resumes. Capability Statements must not include links to internet web site addresses (URLs) or otherwise direct readers to alternate sources of information. Font size must be 10 to 12 points. Spacing must be no more than 15 characters per inch. Within a vertical inch, there must be no more than six lines of text. Print margins must be at least one-inch on each edge of the paper. Print setup should be single-sided on standard letter size paper (8.5 x 11" in the U.S., A4 in Europe). All proprietary information should be marked as such. Required Business Information • DUNS. • Company Name. • Company Address. • Company Point of Contact, Phone and Email address • Current GSA Schedules and/or Government-wide Acquisition Contracts (GWACs) appropriate to this Sources Sought. • Do you have a Government approved accounting system? If so, please identify the agency that approved the system. • Type of Company (i.e., small business, 8(a), woman owned, veteran owned, etc.) as validated via the System for Award Management (SAM) located at https://www.sam.gov/index.html/#1. This indication should be clearly marked on the first page of your Capability Statement (preferable placed under the eligible small business concern's name and address). Number of Copies Please submit one (1) electric copy of your response as follows: All Capability Statements sent in response to this Small Business Sources Sought notice must be submitted electronically (via e-mail) to Swee Teo, Contracting Officer, at teosl@niaid.nih.gov in MS Word or Adobe Portable Document Format (PDF). The e-mail subject line must specify HHS-NIH-NIAID-SBSS-16-NIHAI2016061. Facsimile responses will not be accepted. Common Cut-off Date Electronically submitted tailored capability statements are due no later than 3:30PM (Eastern Prevailing Time) on 11/19/2015. CAPABILITY STATEMENTS RECEIVED AFTER THIS DATE AND TIME WILL NOT BE CONSIDERED. Disclaimer and Important Notes This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."
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