SOURCES SOUGHT
68 -- Chemical Testing
- Notice Date
- 11/17/2015
- Notice Type
- Sources Sought
- NAICS
- 325199
— All Other Basic Organic Chemical Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211 - MSC 9559, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- hhs-nih-nida-sssa-ss-2016-21
- Archive Date
- 12/10/2015
- Point of Contact
- Rodney E. Brooks, Phone: 3014020751
- E-Mail Address
-
rodney.brooks@nih.gov
(rodney.brooks@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- SOURCES SOUGHT NOTICE TEMPLATE 1.Solicitation Number: HHS-NIH-NIDA-SSSA-SS-2016-21 2.Title: Chemical testing 3.Classification Code: 68 Chemicals and Chemical Products 4.NAICS Code: 325199 Chemical Manufacturing- All other basic organic chemical manufacturing This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Background: The National Institutes of Health (NIH) is the nation's leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people's health and save lives. The National Center for Advancing Translational Sciences (NCATS) is a part of the National Institutes of Health (NIH), which mission it is to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions. The NCATS Chemical Genomics Center (NCGC) is tasked with identifying and developing novel small molecule leads against a wide spectrum of human disease targets, which it accomplishes by screening thousands of small molecules in collaboration with both intra-and extramural researchers. In pursuit of this goal, the Center has a strong internal transdisciplinary team of scientists who continually discover novel small molecules for application against a wide range of human diseases. Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2) catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 and ay regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. Furthermore, PIP4K2 may also negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P and may be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. Lysine-specific demethylase 5B (KDM5B) is a histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. KDM5B does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. It demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4' and acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma and represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. Both these proteins are of great interest to study for NCGC and hence, we seek to profile 5 proprietary compounds against these proteins (each) using surface plasmon resonance. We have previously worked with this vendor who developed a custom, proprietary method for running the SPR against another target, IDH1. The results were used as part of the CBC project and we now expect to continue using these precise services to allow for continuity of data. Purpose and Objectives: The purpose of this requirement is to obtain bioanalytical testing services to characterize PIP4K2 and KDM5B and then assess 5 compounds for each protein. The vendor shall characterized ATP, ADP, and 1 control compound against three forms of PIP4K2 and characterizes full-length and truncated form of KDM5B. Upon completion of these services, the contractor shall profile 5 small molecules for PIP4K2 and KDM5 each using a proprietary method used previously against IDH1. The contract shall aslo provide binding constant to NCGC within 4 weeks of start of experiment. The NCATS Chemical Genomics Center NCGC is responsible for providing vendor with proteins and compounds. Anticipated period of performance: 5 weeks after receipt of the contract award Capability statement /information sought. Interested organizations must provide clear and convincing documentation of their capability of providing the item(s) specified in this notice. Interested organizations that believe they possess the ability to provide the required items must submit specific documentation of their ability to meet each of the project requirements to the Contract Specialist. The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HUBZone, etc.), pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2" x 11" paper size, with 1" top, bottom, left and right margins, and with single or double spacing. The information submitted must be must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer. Facsimile responses are NOT accepted. The response must be submitted to Rodney Brooks, Contract Specialist at e-mail address rodney.brooks@nih.gov and NIDASSSAPurchaseRequ@mail.nih.gov. The response must be received on or before November 27, 2015 12:00 pm eastern time. "Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."
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-
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- Record
- SN03947942-W 20151119/151117234707-8452494d0f35facb70314f171f3c6d9b (fbodaily.com)
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