SOLICITATION NOTICE
Q -- Laboratory Testing Services of Telomere Length Assays for Validation Study of the Role of Donor and Recipient Telomere Length in Outcomes After Hematopoietic Stem Cell Transplant in Patients with Acquired Severe Aplastic Anemia: Flow FISH Study
- Notice Date
- 12/1/2015
- Notice Type
- Presolicitation
- NAICS
- 621511
— Medical Laboratories
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E128, Rockville, Maryland, 20852, United States
- ZIP Code
- 20852
- Solicitation Number
- N02-CP-62514-76
- Archive Date
- 12/12/2015
- Point of Contact
- Catherine Muir, Phone: (240) 276-5434
- E-Mail Address
-
muirca@mail.nih.gov
(muirca@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Contracting Office Address: Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E144, Bethesda, MD 20892, UNITED STATES Description: National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), Clinical Genetics Branch (CGB), plans to procure on a sole source basis the services for telomere length Assay testing from the Repeat Diagnostics, Suite 309-267 West Esplanade, North Vancouver, BC V7M 1A5 CANADA. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1) and is exempt from the requirements of FAR Part 6. The North American Industry Classification System code is 621511 and the business size standard is $32.5M. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. The period of performance will be twelve (12) months from date of award. It has been determined there are no opportunities to acquire green products or services for this procurement. The Division of Cancer Epidemiology and Genetics (DCEG) is a research program of the National Cancer Institute (NCI), one of the National Institutes of Health (NIH). The Division is the world's most comprehensive cancer epidemiology research group. Its renowned epidemiologists, geneticists, and biostatisticians conduct population and multidisciplinary research to discover the genetic and environmental determinants of cancer and new approaches to cancer prevention. The Division's research impacts public health policy in the United States and around the world. The Clinical Genetics Branch (CGB), DCEG, NCI, NIH is engaged in an ongoing clinical genetics study that shows, that among patients who received hematopoietic stem cell transplant (HSCT) for severe aplastic anemia (SAA), longer donor telomere length was associated with a higher overall survival probability. Because of the clinical importance and the translational potential of such finding in refining donor selection, the CGB designed several studies to validate its previous work. This procurement is part of this effort in which the CGB will use the CLIA-certified flow FISH assay to precisely quantify donor telomere length and correlate their measurement with patient HSCT outcomes in a subset of 220 donors with available blood samples from the National Marrow Donor Program (NMDP) repository. This particular study is part of a comprehensive, multidisciplinary, intramural research program within the DCEG's Human Genetics Program which is focused upon elucidation of the entire spectrum of scientific and clinical issues related to familial and hereditary forms of cancer. This is an ongoing study, and this submission is a continuation of that work and not new work. Contractor shall perform the following tasks: • Measure telomere length in provided samples using flow FISH 6-panel assay • Provide the NCI Technical Point of Contact with a data file containing: o Sample ID, age of recipient and age of donor o Telomere length absolute measurement for all cell types o Telomere length percentile in relation to donor age-matched controls o Telomere length percentile in relation to recipient age-matched controls Reporting and/or Deliverables: All telomere length measurements are expected to be completed within eleven (11) months of the Period of Performance. The NCI Technical Point of Contact will coordinate / communicate the format required for the data file referenced in Section C, with/to the Contractor. The data file is to be sent by email to the NCI Technical Point of Contact. Government Responsibilities: • The NCI Technical Point of Contact will follow-up with the Contractor to ensure the completeness and accuracy of collected data and tumor tissue samples. • The NCI Technical Point of Contact will notify the Contractor prior to shipment of specimens so that the recipient will be available to receive the shipment. Inspection and Acceptance: • The reports defined above will be scrutinized and subsequently accepted within 30 days of receipt. This laboratory testing service is provided by Repeat Diagnostics. Repeat Diagnostics is the only known laboratory that can perform the studies required in the SOW. The proposed Vendor has US CLIA-certification, and the required telomere length assay by flow-FISH. They are uniquely qualified in the development and implementation of this assay, which is both sensitive and specific to this requirement. This study uses cryo-preserved samples. The proposed Vendor is the only known laboratory that can use the available sample source to provide telomere length measurements using the required assay. The CGB's study is ongoing, and the performance characteristics and quality of the needed services are required for maintaining the integrity of on-going studies. A change would be disruptive to the ability to analyze their cumulative results. This study is an integral part of an on-going NCI protocol. This notice is not a request for competitive quotation. However, if any interested party, especially small businesses, believes it can meet the above requirement, it may submit a capability statement, proposal, or quotation, which shall be considered by the agency. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow the NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 10:30AM EST, on Dec. 11, 2015. All responses and questions must be in writing and faxed (240) 276-5401 or emailed to Catherine Muir, Contracting Officer via electronic mail at muirca@mail.nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, Contractors must be registered and have valid, current Entity Record, including current Representations and Certifications, in the System for Award Management (SAM) through SAM.gov. Reference: N02-CP-62514-76 on all correspondence.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/RCB/N02-CP-62514-76/listing.html)
- Record
- SN03958022-W 20151203/151201234844-29ec5f2ac474367ac7b087cb07c15926 (fbodaily.com)
- Source
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