SOURCES SOUGHT
B -- Use of Mouse Knockout Models to Determine the Function of Insulin in Taste Bud Cells
- Notice Date
- 12/28/2015
- Notice Type
- Sources Sought
- NAICS
- 541380
— Testing Laboratories
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211 - MSC 9559, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-2016-85
- Archive Date
- 1/19/2016
- Point of Contact
- Samantha A. Kelly, Phone: 3014028855
- E-Mail Address
-
samantha.kelly2@nih.gov
(samantha.kelly2@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- SOURCES SOUGHT NOTICE 1.Solicitation Number: HHS-NIH-NIDA-SSSA- 2016-85 2.Title: Use of Mouse Knockout Models to Determine the Function of Insulin in Taste Bud Cells 3.Classification Code: B- Other than R&D Studies 4.NAICS Code: 541380- Testing Laboratories 5.Description: This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Background: The National Institute on Aging (NIA) is conducting a project to determine the function of insulin in the taste buds cells of the tongue by specifically deleting insulin in the taste bud cells of the tongue of mice but allowing for normal expression of insulin in the islets of Langerhans in the pancreas. Purpose and Objectives: The purpose of this requirement is to procure testing services for three mouse models and produce a fourth mouse model in support of the subject project. Project requirements: The contractor shall provide the following services: 1.The contractor is required to make three transgenic mouse models and provide two homozygous mice for each of these mouse models to NIA. 2.Contractor shall use sophisticated molecular biology tools and their expertise to determine how to do this exactly and will make the constructs to inject into the ES cell lines and then breed the mice to get two homozygous which is the deliverable to the NIA. 3.The contractor will then cross two of these mouse models to produce a fourth mouse model and provide NIA with two mice homozygous for the two genes in question. The four mouse models shall be performed as follows: 1.Mouse Model # 1 Mouse model in which the insulin 1 gene is absent in the entire animal i.e. a conventional knockout of the insulin 1 gene. 2.Mouse Model # 2 Mouse model in which the insulin 2 gene is absent in the entire animal i.e. a conventional knockout of the insulin 2 gene. 3.Mouse Model # 3 Mouse model in which the insulin 2 gene is floxed in the entire animal i.e. a mouse that will allow us to make a conditional knockout of the insulin 2 gene. 4.Mouse Model #4 They will breed mouse model # 1 with mouse model #3 to generate mice that are homozygous for both mutations. Contractor shall provide the NIA with two mice that are homozygous for both transgenes. Anticipated period of performance: 8-10 months after Contractor receipt of Purchase Order. Capability statement /information sought. Contractors that believe they possess the ability to provide the requirement should submit documentation of their ability to meet each of the project requirements to the Contract Specialist. The response should directly and specifically state in the, capabilities statement, which project requirements you can supply. Contractors must also provide their Company Name, DUNS Number, Physical Address, Point of Contact, and Size and Type of Business (e.g., 8(a), HubZone, etc.) pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2" x 11" paper size, with 1" top, bottom, left and right margins, and with single or double spacing. The information submitted must be must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses (capability statements) sent in response to this Small Business Sources Sought Notice must be submitted electronically (via e-mail) to the Contract Specialist. Facsimile responses are NOT accepted. The response must be submitted to Samantha Kelly, Contract Specialist at e-mail address Samantha.Kelly2@nih.gov. The response must be received on or before January 4, 2016 at 8:00AM, eastern time. "Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."
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