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FBO DAILY - FEDBIZOPPS ISSUE OF JANUARY 13, 2016 FBO #5164
SOLICITATION NOTICE

B -- NC3000 cademic package for Functional analysis of genes related to type 2 diabetes (T2D)

Notice Date

1/11/2016
 

Notice Type

Presolicitation
 

NAICS

334516 — Analytical Laboratory Instrument Manufacturing
 

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
 

ZIP Code

20892-7902
 

Solicitation Number

HHS-NIH-NHLBI-CSB-(HG)-2016-054-DM
 

Archive Date

1/30/2016
 

Point of Contact

Dorothy Maxwell, Phone: 301-435-0352
 

E-Mail Address

maxwelld@mail.nih.gov
(maxwelld@mail.nih.gov)
 

Small Business Set-Aside

N/A
 

Description

INTRODUCTION: THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR A PROPOSAL. A SOLICITATION DOCUMENT WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Heart, Lung, and Blood Institute (NHLBI) Office of Acquisition (OA) on behalf of the National Human Genome Research Institute, (NHGRI), intends to negotiate and award a purchase order on a noncompetitive sole source basis to ChemoMetec, Gydevang 43, DK-3450 Allerod, Denmark to procure the following: ISSO and 508 Compliance is Obtained through NHGRI. Procurement: 1. NucleoCounter®, NC-3000 cademic package including: All developed assays, power cable, UL Power Supply, USB cable, Cleaning Kit and Free Software Updates; Item Number: 970-3002, Quantity: One Each. 2. Training full day IQOQ by field application scientist, Item Number: 982-3001, Quantity: One Each. 3. NC-3000 Flexicyte Software Platform, Item Number: 970-3002, Quantity: One Each. 4. Warranty, Item Number: 983-3001, Quantity: One Each. Background : The National Institute of Health (NIH) is the nation's leading medical research agency and the primary Federal agency seeking fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The National Human Genome Research Institute (NHGRI), mission has expanded to encompass a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. A critical part of the NHGRI mission continues to be the study of the ethical, legal and social implications (ELSI) of genome research. The Medical Genomics and Metabolic Genetics Branch/Molecular Genetics Section Investigators use a broad range of tools to understand how health and disease are related to genetic, genomic and metabolic variation. Investigators study a broad spectrum of disorders, from common diseases associated with common variants to the rarest diseases associated with uncommon, sometimes unique variants. Scientific Investigators sometimes study disorders that are not inherited at all, which are due to somatic mosaicism-a difference in genetic composition among cells in an individual. Additionally also study how the genome influences normal metabolic processes. MGMGB investigators apply tools ranging from high-throughput biology to clinical and animal research. A unifying theme in their research is that the human is the most complex, fascin MGMGB investigators use the rich resources and technologies of the Human Genome Project to develop more sophisticated ways of understanding pathophysiology, diagnosis and treatment of disease.ating and important system in which one can study the effects of heritable variation. For twenty years NHGRI have been engaged in a large collaborative study entitled FUSION (Finland - United States Investigation of NIDDM), in which more than 20,000 individuals with type 2 diabetes (T2D) (and suitable controls) from Finland are being studied. In addition we are involved in research on a rare prematurer aging disease, Hutchinson-Gilford progeria syndrome (HGPS) where children a born with a de novo mutation in the LMNA gene, display characteristics of aging at extremely early age and die of cardiovascular disease or stroke in their teenage years. Research in these areas contribute to the knowledge base of common disease that affects hundreds of millions of people worldwide achieving epidemic proportion as well as gaining knowledge of the aging process which affects not only the rare cases as in HGPS but also insight into common aging in normal individuals. Purpose and Objectives : ChemoMetec NucleoCounter NC-3000 is an advanced cell analyzer utilizing fluorescence imaging to characterize cell properties. The NC-3000 can perform high speed cell count and viability determination and includes plug-and-play analytical assays of mammalian, yeast and insect cells. Pre-defined assays include a unique 5-minute cell cycle assay and a selection of apoptosis assays. FlexiCyte license allow users the ability to create protocols choosing light source, emission filters and detailed settings. The accompanying intuitive software can be used for data analysis of the results and has unlimited licenses. The NC-3000 benchtop image cytometer ensures flow-like analysis with high reproducibility and is maintenance and calibration free. The NC-3000 is capable of one-step viability and cell count without any pre-treatment utilizing the Via1-Cassette for viability and cell count determination. The inside of the Via1-Cassette is coated with the two fluorescent dyes acridine orange and DAPI automatically staining the total and dead cell populations, respectively. The Via1-Cassette is volume calibrated ensuring high precision viability and cell count determination. The NC-3000 is capable of high speed viability and cell count of small sample volumes. The multi-chamber A8 slide enables high speed viability and cell count determinations of insect and mammalian cells with 8 counts in less than 3 minutes. Simply mix cell suspension with fluorescent dyes, load the chamber and press run. ChemoMetec offers optimized counting and viability protocols for even aggregated cells or cells growing on microcarriers or in sphere cultures. When counting manually the scientist can visually verify the counting. This verification of the count can likewise be performed with the intuitive NucleoView software included with the NC-3000. Scatterplots and plots are interlinked making it possible to verify cell populations visually. Other Considerations : The Government's minimum requirements are as follows: 1. Instrument must have the capability to run single sample in under 60 seconds; 2. Instrument must have the capability to determine cell viability and cell density; 3. Instrument must have the capability to determine percentage of cell aggregates; 4. Instrument must have a software package with unlimited installations that displays results as cell images, cell viability, cell density, cell diameter, and capability to export to excel; 5. Instrument must be able to perform cell counts with a sample volume of ≤60 ul per count; 6. Instrument must use single use calibrated cassettes with no pre-treatment of cells required; 7. Instrument must be functional without required maintenance, calibration and service; 8. Instrument must be able to work in the Cell Culture lab environment; 9. Instrument must provide statistically comparable results to Cedex HiRes cell counters currently in use; 10. Instrument must utilize DAPI and Acridine Orange to stain cells; 11. Instrument must include an IQOQ package option. Period of Performance : 12-Months Regulatory Authority : This acquisition is conducted under the authority of the Federal Acquisition Regulations (FAR) Subpart 13.106-1(b) Soliciting from a single source and is not expected to exceed the simplified acquisition threshold, only one responsible source and no other supplies or services will satisfy agency requirements. Statutory Authority: This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures, Contracts awarded using FAR Part 13-Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6-Competition Requirements. Additional Information: Industry Classification (NAICS) Code is Industry Classification (NAICS) Code is 541712, Research and Development in the Physical, Engineering, and Life Sciences (except biotechnology) and small business size standard is 500. The acquisition is being conducted under FAR Part 13, simplified acquisition procedures, therefore the requirements of FAR Part 6 B Competitive Requirements are not applicable (FAR Part 6.001). The resultant Contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 05-85-1 (January 4, 2016). This requirement is under the SAT of $150,000.00. This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by January 15, 2016 and must reference synopsis number HHS-NIH-NHLBI-CSB-(HG)-2016-054-DM by 7:30 a.m. Eastern Time, may be submitted to the National, Heart, Lung and Blood Institute, Office of Acquisition, COAC Services Branch, 6701 Rockledge Drive, Suite 6149, Bethesda, Maryland 20892-7902, Attention: Dorothy Maxwell. Response may be submitted electronically to maxwelld@mail.nih.gov. Faxes will not be accepted. Responses will only be accepted if dated and signed by an authorized company representative. "All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency."
 

Web Link

FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/HHS-NIH-NHLBI-CSB-(HG)-2016-054-DM/listing.html)
 

Place of Performance

Address: Delivery to Government's Location: Building 50 South Drive, Bethesda, Maryland, 20892, United States

Zip Code: 20892
 

Record

SN03987950-W 20160113/160111234422-35472c7e0df7cd86a1df9d1ee515e4e0 (fbodaily.com)
 

Source

FedBizOpps Link to This Notice
(may not be valid after Archive Date)

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