SOLICITATION NOTICE
65 -- Zeiss LSM 880 Microscope System Airyscan
- Notice Date
- 2/29/2016
- Notice Type
- Presolicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- HHS-NIH-NHLBI-CSB-(HG)-2016-094-DM
- Archive Date
- 3/22/2016
- Point of Contact
- Dorothy Maxwell, Phone: 301-435-0352
- E-Mail Address
-
maxwelld@mail.nih.gov
(maxwelld@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- INTRODUCTION: THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR A PROPOSAL. A SOLICITATION DOCUMENT WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Heart, Lung, and Blood Institute (NHLBI) Office of Acquisition (OA) on behalf of the National Human Genome Research Institute, (NHGRI), intends to negotiate and award a purchase order on a noncompetitive sole source basis to Carl Zeiss Microscopy, LLC, One Zeiss Drive, Thornwood, New York 10594-1939 to procure a LSM 880 Microscope System, (Specified Brand Name: Carl Zeiss Microscopy) NO REFURBISHED OR USED SYSTEMS ARE ACCEPTABLE. Procurement: • LSM 880 2+1Ch NLO Ar, 561, 633, Catalog Number: 4109002147073000, Quantity: One Each. • 405 cw Laser Kit for LSM 710/780, Catalog Number: 4109009120830000, Quantity: One Each. • 405 cw Laser Kit for LSM 710/780, Catalog Number: 4109021410122000, Quantity: One Each. • Table for LSM 880 w/Airyscan 36x48, RP, Catalog Number: 4108432954814000, Quantity: One Each. • Airyscan Module for LSM 880, Catalog Number: 4109002058580000, Quantity: One Each. • Memory 32 GB (2x16) DDR3-1600 MHz ECC, Catalog Number: 4103033202000000, Quantity: Two Each. • Support for LSM 880 Axio Observer + NLO, Quantity: One Each. • C-Apochromat 40x/1,2 W Korr. FCS, Catalog Number: 4217679971711000, Quantity: One Each. • Plan-Apochromat 63x/1.40 Oil DIC f/ELYRA, Catalog Number: 4207829900799000, Quantity: One Each. • Incubator XL multi S1, Catalog Number: 4118579400000000, Quantity: One Each. • ZEN Module FRET Hardware License Key, Catalog Number: 4101361011110000, Quantity: One Each. • ZEN Module HDR ROI-Scan Hardware License, Catalog Number: 4101361007110000, Quantity: One Each. • ZEN Module Tiles / Positions HW Lic. Key, Catalog Number: 4101361025110000, Quantity: One Each. • Transmitted light detector T-PMT, Catalog Number: 4239230000000000, Quantity: One Each. • Reflector turret 6x LSM ACR, Catalog Number: • Extreme Workstation Win7 x64+30" Monitor, Catalog Number: 4109029901840000, Quantity: One Each. • Scanning Stage 130x100 STEP, Catalog Number: 4320299904000000, Quantity: One Each. Background: The National Institute of Health (NIH) is the nation's leading medical research agency and the primary Federal agency seeking fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The National Human Genome Research Institute (NHGRI), mission has expanded to encompass a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. A critical part of the NHGRI mission continues to be the study of the ethical, legal and social implications (ELSI) of genome research. The National Human Genome Research Institute NHGRI), Cytogenetic and Microscopy Core over the past 17 years has invested significant resources to develop a state-of-the-art image acquisition and analysis facility for all NHGRI researchers to pursue and accelerate genome research. The LSM 880 2+1 plus Airyscan system allows researchers to image samples very similar to that of the existing LSM 510 NLO system, reducing the learning curve and wait time. Having the same software simplifies the Cytogenetic and Microscopy Core processes, minimizing labor and time and gives researchers the flexibility to image regularly prepared samples either confocally or through the Airyscan mode (1.7x better XY resolution at 488nm) depending on the needs of the project. Purpose and Objectives: NHGRI Cytogenetic and Microscopy Core Facility is a high-resolution imaging core facility supporting all labs within NHGRI. Microscopy has evolved from basic light microscopes to super-resolution systems and as the technology advances so does the demand for our services. The Cytogenetic and Microscopy Core facility currently has two conventional wide-field fluorescent scopes; a deconvolution/restoration wide-field system; a Spinning Disk/TIRFconfocal system; and a LSM 510 NLO confocal system which all are in full operation. However, the LSM 510 NLO confocal system will no longer be under a service contract agreement (Zeiss has a 7 year cutoff between system versions) due to its age (12 years old). We purpose to upgrade this LSM 510 NLO to the newest LSM 880 2+1 plus Airyscan system using Zeiss' 25% trade-in promotional discount to save the government over $155,000. Since the Cytogenetic and Microscopy Core is running a system almost every day of the week totaling over 5200 hours in 2014 and projected around 5800 hours for 2015. The Cytogenetic and Microscopy Core will need an upgraded system, with a service contract in place, to meet high demand. The LSM 880 2+1 plus Airyscan system has a unique proprietary Airyscan detection unit consisting of a calibrated 32-element Gallium Arsenide Phosphide (GaAsP) PMT with typical QE >45 % (peak) and adjustable zoom optics (to accommodate different objectives). The 32-element proprietary area detector is arranged in a compound eye fashion where the central element is adjusted to lie on the optical axis. The Airyscan detector is operated in three different modes: super-resolution, variable pinhole and standard confocal. The adjustable zoom optics always ensures that a defined amount of light (1.25 airy units for super-resolution and confocal mode & 3.5 airy units for variable pinhole) is projected onto the detector. In super-resolution mode the Airyscan detector system achieves images with spatial resolutions of 140nm in XY and 400nm in Z when utilizing 488nm excitation and a 63x 1.4 NA Plan-Apochromat objective. Additionally, the system provides a real-time preview of the super-resolution image while data is being acquired. In variable pinhole mode the Airyscan allows the image optical section size of each image plane to be set after image acquisition during post processing. And in confocal mode a traditional pinhole aperture is used in addition to the detectors 32 GaAsP detection elements. All elements are then summed together to yield a traditional confocal image that can be combined with the two other PMT detectors on the system. In addition to the Airyscan detection unit, the entire 3 channel quasar detector (one GaAsP plus two standard PMTs) is liquid cooled, which improves data handling as well as overall signal to noise in the image. The one channel GaAsP and the red-shifted PMT function in both integration (digital oversampling) or photon counting mode, for extreme imaging flexibility and sensitivity when handling live cells or low expressing samples. The added new image format from 4x1 to 8192x8192 pixels with up to 16 bit depth (65536 gray values) in all PMT and GaAsP channels adds to the image quality researcher's demand. Finally, absolute linear scanner movement to ensure equal pixel dwell-times is a prerequisite for any quantitative studies. Short scanner turnaround times, > 85% of the frame time is effectively used for image acquisition and the OSCiscan for artifact-free, fast and reliable bidirectional scanning without the need of manual adjustment. Other Considerations: Contractor Requirements : • The Contractor shall provide uncrating and set up of the instrument. Inspection and Acceptance Requirements: • The Contractor shall deliver instrument, computer and accessories in good working condition. The Government will verify satisfactory performance of the instrument. Anticipated Period of Performance : • Delivery Upon Award Regulatory Authority: This acquisition is conducted under the authority of the Federal Acquisition Regulations (FAR) Subpart 13.106-1(b) Soliciting from a single source and is not expected to exceed the simplified acquisition threshold, only one responsible source and no other supplies or services will satisfy agency requirements. Statutory Authority: This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures, Contracts awarded using FAR Part 13-Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6-Competition Requirements. Additional Information: Industry Classification (NAICS) Code is 334516, Analytical Laboratory Instrument Manufacturing and small business size standard is 500. The acquisition is being conducted under FAR Part 13, simplified acquisition procedures, therefore the requirements of FAR Part 6 B Competitive Requirements are not applicable (FAR Part 6.001). The resultant Contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2005-85-2 (February 26, 2016). This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by March 7, 2016 and must reference synopsis number HHS-NIH-NHLBI-CSB-(HG)-2016-094-DM by 7:30 a.m. Eastern Time, may be submitted to the National, Heart, Lung and Blood Institute, Office of Acquisition, COAC Services Branch, 6701 Rockledge Drive, Suite 6149, Bethesda, Maryland 20892-7902, Attention: Dorothy Maxwell. Response may be submitted electronically to maxwelld@mail.nih.gov. Faxes will not be accepted. Responses will only be accepted if dated and signed by an authorized company representative. "All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/HHS-NIH-NHLBI-CSB-(HG)-2016-094-DM/listing.html)
- Place of Performance
- Address: NIH 49 Convent Drive, Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN04034234-W 20160302/160229235040-90a2cd2d64c957c962f54f26963305da (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |