SOLICITATION NOTICE
66 -- Upgrade of Core EVOS Auto FL Cell Imaging System to include On-Stage Incubator and Integration of existing microscope objectives and proprietary LED light cubes
- Notice Date
- 3/11/2016
- Notice Type
- Presolicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E128, Rockville, Maryland, 20852, United States
- ZIP Code
- 20852
- Solicitation Number
- N02RC62547-76
- Archive Date
- 3/22/2016
- Point of Contact
- Catherine Muir, Phone: (240) 276-5434
- E-Mail Address
-
muirca@mail.nih.gov
(muirca@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Contracting Office Address: Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E144, Bethesda, MD 20892, UNITED STATES. Description: National Cancer Institute (NCI), Center for Cancer Research (CCR), Laboratory of Cancer Biology and Genetics (LCBG), plans to procure on a sole source basis an upgrade to the core of the Government owned EVOS Auto FL cell imaging system to include an on-stage incubator system that is compatible with existing Government-owned existing microscope objectives and proprietary LED light cubes from Life Technologies, Corp., a division of Thermo Fisher Scientific, Inc., 5791 Van Allen Way, Carlsbad, CA 92008. The response close date of this notice for this requirement is in accordance with FAR 5.203(a)(1). This acquisition will be processed under FAR Part 12 - Acquisition for Commercial Items and in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1), and is exempt from the requirements of FAR Part 6.The North American Industry Classification System code is 334516 and the business size standard is 500 employees. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. The period of performance is twelve (12) months from date of award. It has been determined there are no opportunities to acquire green products or services for this procurement. The LCBG conducts an integrated research program to elucidate the molecular and biological mechanisms underlying cancer progression and to use this information to develop novel anti-cancer therapies. Investigators in the LCBG have recently developed a powerful fluorescent imaging approach to studying the cancer stem cells, a clinically critical subpopulation of cells in a tumor that are responsible for maintenance of the tumor and recurrence after therapy. With this approach, cancer stem cell properties can be monitored in real time and the effect of drugs on this cell population assessed through fate-mapping studies. However, to meet these objectives, the additional capabilities of accurate image registration and environmental control (temperature, gas composition, humidity) necessitate the upgrade to an instrument that has an automated X-Y scanning stage and has an on-stage incubator. The LCBG requires an epifluorescent microscope for cell imaging for many aspects of the laboratory cancer research program to understand the mechanisms underlying the progression of cancer from early lesion to late stage metastatic disease. Specifically there is currently a need for a Cell Imaging system that will allow cell fate mapping by time-lapse videomicroscopy to address the role of the cancer stem cell in therapeutic resistance. This information should help in the design of more effective cancer therapies. The LCBG's existing EVOS instrument can be upgraded to acquire this capability by trading in the core instrument for credit and exchanging it for an instrument core that includes an automated motorized X-Y scanning stage (to allow regions of the sample to be repeatedly imaged over time) and an on-stage incubator (to keep the cancer cell cultures alive during the extended periods of the time-lapse microscopic imaging). In going for a trade-in, The LCBG can re-use the microscope objectives and proprietary light cubes from the original system. The upgraded microscope will be a multi-user instrument, and the EVOS system is uniquely robust because of the proprietary integrated instrument design which means there are no bulbs to change and the optics cannot be misaligned during use and it is user-friendly due to the embedded operating system and its unique software. Contractor shall perform one (1) hardware upgrade of the EVOS auto FL cell imaging system to include on-stage incubator and integration of existing microscope objectives and proprietary LED light cubes system, and software upgrade on the Government-owned EVOS Auto FL Cell Imaging System; hardware upgrade to include 22" Multi-Touch Monitor; External PC with 16 GB RAM; FL Auto Accessory kit; 3 US Power Cords; Condenser Slider, Diffusion; Condenser Slider, Block; Vessel Holder for Slides (AMEPVH001); Intermediate Stage Plate (AMEPVH022); Light Shield; Dust Cover; USB A to B cable (6Ft)/ DVI cable (6Ft); USB stick; Cartridge Extraction Tool; Corded Optical USB Mouse; Light Cube Access Door; and software upgrade to include advanced system software featuring high-resolution mosaic tiling, multi-position scanning, object counting, and time-lapse interface software during the contract period. The upgrade shall be performed by technically qualified factory trained personnel. Life Technologies, Corp. is the only known manufacturer of the required EVOS FL Auto Cell Imaging System (AMAFD1000). It is the only imaging system available on the market with all the required specifications in the Statement of Work, provided in this notice. Furthermore, the required incubator integrates into the microscope software which is a unique feature, and the small footprint and portability of the instrument are not found in other cell imaging systems. This system is replacing an existing EVOS system, and laboratory scientists will be familiar with the upgraded system. Use of the imaging system will be easy to learn because of the similar setup as the system being replaced. The compatibility and integration of the existing equipment elements with the upgraded equipment core is crucial for efficient equipment operation, and the throughput of the laboratory.,Any deviation from the required specifications could ruin countless hours of work, distort and destroy the integrity of information and/or ruin further studies. The data collection software supplied with this equipment, which acts as the instruments operating system, is proprietary and updates and patches are solely available through the proposed Vendor. The proposed Vendor has unlimited access to parts and technical support both of which are of a proprietary nature and included in the contract price. This notice is not a request for competitive quotation. However, if any interested party, especially small businesses, believes it can meet the above requirement, it may submit a capability statement, proposal, or quotation, which shall be considered by the agency. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow the NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 4:00PM EDT, on March 21, 2016. All responses and questions must be in writing and faxed (240) 276-5401 or emailed to Catherine Muir, Contracting Officer via electronic mail at muirca@mail.nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, Contractors must be registered and have valid, current Entity Record, including current Representations and Certifications, in the System for Award Management (SAM) through SAM.gov. Reference: N02RC62547-76 on all correspondence.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/RCB/N02RC62547-76 /listing.html)
- Place of Performance
- Address: Bethesda, Maryland, United States
- Record
- SN04047782-W 20160313/160311234647-9bb9176257c8a02548bcaec906a9baf9 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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