SOLICITATION NOTICE
Q -- Acquisition of Laboratory Testing and Annotations of Serum and Coffee Metabolites and Data Analysis in the BREW and ATBC Studies
- Notice Date
- 6/6/2016
- Notice Type
- Presolicitation
- NAICS
- 621511
— Medical Laboratories
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E128, Rockville, Maryland, 20852, United States
- ZIP Code
- 20852
- Solicitation Number
- N02CP62598-76
- Archive Date
- 6/21/2016
- Point of Contact
- Catherine Muir, Phone: (240) 276-5434
- E-Mail Address
-
muirca@mail.nih.gov
(muirca@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Contracting Office Address: Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E144, Bethesda, MD 20892, UNITED STATES Description: The National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), Metabolic Epidemiology Branch (MEB), plans to procure on a sole source basis Laboratory Testing to annotate 49 serum and coffee compounds from the ATBC and BREW studies including the purchase of chemical standards, the collection of mass spectral data on these standards and the bioinformatics analysis from the International Agency for Research on Cancer (IARC); 150 cours Albert Thomas; F-69372 Lyon Cedex 08, France. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1) and is exempt from the requirements of FAR Part 6. The North American Industry Classification System code is 621511 and the business size standard is $32.5M. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. The period of performance will be no greater than twelve (12) months from date of award. It has been determined there are no opportunities to acquire green products or services for this procurement. The Division of Cancer Epidemiology and Genetics (DCEG) is a research program of the National Cancer Institute (NCI), one of the National Institutes of Health (NIH). The Division is the world's most comprehensive cancer epidemiology research group. Its renowned epidemiologists, geneticists, and biostatisticians conduct population and multidisciplinary research to discover the genetic and environmental determinants of cancer and new approaches to cancer prevention. The Division's research impacts public health policy in the United States and around the world. MEB's research mission is to define causal relationships between diet, energy balance, hormones, tobacco, and cancer. The MEB conducts interdisciplinary research to understand the role of diet, energy balance, hormones, tobacco, and other exposures in causing and preventing cancer. It studies how these exposures relate to a broad variety of cancers with researchers focusing on breast, colon, endometrium, esophagus, liver, stomach, ovary, pancreas, and prostate. It uses traditional epidemiological methods combined with a variety of molecular methods including genomic analysis, metabolomics, microbiomics, and molecular pathology. The purpose of this procurement is to annotate 49 serum and coffee compounds from the ATBC and BREW studies including the purchase of chemical standards, the collection of mass spectral data on these standards and the bioinformatics analysis. Results from the MEB's studies, and those of others, have suggested that coffee drinking may protect against the development of liver cancer and chronic liver disease, a related pre-cursor condition. However, coffee contains over 1,500 chemical compounds, and it remains unclear which components of coffee drive these potentially protective associations. Metabolomics is an approach which simultaneously measures many small metabolites in biological fluids and can be used to identify which specific compounds from coffee are related to liver cancer and chronic liver disease. The proposed project builds off of the MEB's previous work in which the IARC laboratory generated the retention time, mass, and peak data for more than 1,000 coffee and serum metabolites. This data was used to tentatively assign biochemical identifications using a reference library curated by the IARC laboratory. The current study seeks to chemically confirm the identity of 49 key metabolites, including coffee-related compounds that are associated with liver cancer and liver disease mortality using authenticated standards, in the IARC laboratory. The IARC has developed a metabolomics platform optimized for measuring polyphenols, which are abundant in coffee, and has demonstrated high accuracy and reproducibility in these assays as evidenced by their substantial publication record and work in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. Contractor shall perform the following, unless otherwise noted: TECHNICL REQUIREMENTS: The Contractor shall annotate 49 serum and coffee compounds from the ATBC and BREW studies including the procurement of chemical standards, collection of mass spectral data on these standards and complete corresponding bioinformatics analysis. Communicate to the NCI Technical Point of Contact immediately via email or phone call if any problems. The Contractor shall notify the NCI Technical Point of Contact immediately via e-mail or phone call if any unusual problems develop over the course of the project and/or explanations for repeating analyses, such as failure of analytical and quality control procedures, breakdown of freezers, instrumentation and equipment, and major changes in personnel that would produce delays or that would adversely influence the quality of the laboratory performance. GOVERNMENT RESPONSIBILITIES: The NCI Technical Point of Contact shall identify the key compounds of interest from the ATBC and BREW samples. Upon the receipt of the Contractor's report, the NCI Technical Point of Contact shall examine the report data. REPORTING REQUIREMENTS AND DELIVERABLES: The Contractor, with input from the NCI Technical Point of Contact, shall provide a report of the methods used and the data generated and annotation analysis to the NCI Technical Point of Contact. This report shall be submitted by email, immediately on completion of the work and no later than one year after the date of the award. INSPECTION AND ACCEPTANCE CRITERIA: The reports, containing relevant data items, per above, defined in section E will be scrutinized and subsequently accepted within thirty (30) calendar days of receipt, no later than the end of the twelfth (12th) month of the Period of Performance. PAYMENT: NET 30 days from date of invoice. Payment shall be made after the acceptance of the deliverables in Section E, and submission of invoice pursuant to the invoicing instruction, and to the address shown, in this order. AWARD: Award will be made in the aggregate. The laboratory testing services are provided by the IARC. The IARC was the laboratory used in the MEB's prior studies referenced above, and it has exceptionally high technical reliability and technical properties. To ensure scientific integrity, samples for the MEB's BREW and ATBC studies need to be tested at the laboratory of the IARC using the same authenticated standards on its proprietary platform in order to chemically confirm the identity the key metabolites stated above. The MEB's study is ongoing, and the performance characteristics and quality of the needed services are required for maintaining the integrity of on-going studies. A change would be disruptive to the ability to analyze its cumulative results. For scientific comparability and compatibility, it is imperative the laboratory services be performed by the proposed source. This notice is not a request for competitive quotation. However, if any interested party, especially small businesses, believes it can meet the above requirement, it may submit a capability statement, proposal, or quotation, which shall be considered by the agency. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow the NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 5:00PM EDT, on June 20, 2016. All responses and questions must be in writing and faxed (240) 276-5401 or emailed to Catherine Muir, Contracting Officer via electronic mail at muirca@mail.nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, Contractors must be registered and have valid, current Entity Record, including current Representations and Certifications, in the System for Award Management (SAM) through SAM.gov. Reference: N02CP62598-76 on all correspondence.
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- Record
- SN04139093-W 20160608/160606234145-08d4eaaf6a6d9ec7d7393416ba905b9a (fbodaily.com)
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